Home Total Parenteral Nutrition for Intestinal Failure in Patients with Advanced Small Intestinal Neuroendocrine Neoplasms

Liu, Man; Laskaratos, Faidon-Marios; Bennell, José; Chen, Jie; Toumpanakis, Christos; Mandair, Dalvinder; Caplin, Martyn

doi:10.1080/01635581.2020.1810713

Cited by 4 publications

(8 citation statements)

References 21 publications

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“…cations for the entire study patients with NETs are par are applicable for patients w complications. The results Sagar V 2020 [22] Liu M 2020 [23] Hoda D 2005 [24] Nehra V 2001 [25] + low risk of b ! !…”

Section: Quality Assessmentmentioning

confidence: 97%

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Feasibility of Home Parenteral Nutrition in Patients with Intestinal Failure Due to Neuroendocrine Tumours: A Systematic Review

Clement,

Brown,

Naghibi

et al. 2023

Nutrients

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Introduction: Maintaining adequate nutritional status can be a challenge for patients with small bowel neuroendocrine tumours (NETs). Surgical resection could result in short bowel syndrome (SBS), whilst without surgical resection there is a considerable risk of ischemia or developing an inoperable malignant bowel obstruction (IMBO). SBS or IMBO are forms of intestinal failure (IF) which might require treatment with home parenteral nutrition (HPN). Limited data exist regarding the use of HPN in patients with small bowel neuroendocrine tumours, and it is not frequently considered as a possible treatment. Methods: A systematic review was performed regarding patients with small bowel NETs and IF to report on overall survival and HPN-related complications and create awareness for this treatment. Results: Five articles regarding patients with small bowel NETs or a subgroup of patients with NETs could be identified, mainly case series with major concerns regarding bias. The studies included 60 patients (range 1–41). The overall survival time varied between 0.5 and 154 months on HPN. However, 58% of patients were alive 1 year after commencing HPN. The reported catheter-related bloodstream infection rate was 0.64–2 per 1000 catheter days. Conclusion: This systematic review demonstrates the feasibility of the use of HPN in patients with NETs and IF in expert centres with a reasonable 1-year survival rate and low complication rate. Further research is necessary to compare patients with NETs and IF with and without HPN and the effect of HPN on their quality of life.

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Section: Quality Assessmentmentioning

confidence: 97%

“…All studies included some major concerns regarding bias and none of the studies were free of possible bias. Sagar V 2020 [22] Liu M 2020 [23] Hoda D 2005 [24] Nehra V 2001 [25] + low risk of bias, ! unclear risk of bias.…”

Section: Quality Assessmentmentioning

confidence: 99%

Feasibility of Home Parenteral Nutrition in Patients with Intestinal Failure Due to Neuroendocrine Tumours: A Systematic Review

Clement,

Brown,

Naghibi

et al. 2023

Nutrients

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“…Food consumption is not only driven by a desire for nutrients and satiety; meals are also fundamental elements of human interaction and culture [1]. For patients with advanced cancer suffering from organ dysfunction and/or gastrointestinal tract obstruction as well as critically low food intake, malnutrition represents an overriding threat to survival [2][3][4][5]. A balanced and sufficient nutritional intake is essential to support body functions and ensure growth and maintenance [6].…”

Section: Introductionmentioning

confidence: 99%

Parenteral Nutrition in Advanced Cancer: The Healthcare Providers’ Perspective

et al. 2022

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Introduction:The evidence base for parenteral nutrition (PN) in advanced cancer patients is limited. We studied healthcare providers' (HCPs') experiences with PN in cancer patients, focusing on perceived treatment benefits and challenges. Methods: An 18-item online survey was emailed to HCPs attending one of three regional palliative care seminars held within a 6-month period. The survey included single-response items, multiple-response items, and free text boxes concerning PN. Descriptive statistics and qualitative thematic content analysis were applied. Results: One hundred and two seminar participants completed the survey. Ninety-three percent were female, 86% were nurses/oncological nurses, and 80% worked in primary care. Respondents reported a well-functioning collaboration across levels of care. They perceived that PN may increase the patients' level of energy, improve the general condition, and reduce eating-related distress. On the downside, HCPs observed burdensome side effects, that the treatment was resource-demanding, and that decisions on PN withdrawal were difficult.

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“…We generally use the parenteral route for patients who are unable to use the enteral route. Even though the parenteral delivery system has more advantages than the oral route in some situations [ 6 ], the enteral route is generally recommended due to the known complications of parenteral nutrition [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Intervention Facilitates Food Intake after Epilepsy Surgery

et al. 2021

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Background: We investigated whether nutritional intervention affected food intake after epilepsy surgery and if intravenous infusions were required in patients with epilepsy. We hypothesized that postoperative food intake would be increased by nutritional intervention. The purpose of this study was to compare postoperative food intake in the periods before and after nutritional intervention. Methods: Between September 2015 and October 2020, 124 epilepsy surgeries were performed. Of these, 65 patients who underwent subdural electrode placement followed by open cranial epilepsy surgery were studied. Postoperative total food intake, rate of maintenance of food intake, and total intravenous infusion were compared in the periods before and after nutritional intervention. Results: A total of 26 females and 39 males (age range 3–60, mean 27.1, standard deviation (SD) 14.3, median 26 years) were enrolled. Of these, 18 females and 23 males (3–60, mean 28.2, SD 15.1, median 26 years) were in the pre-nutritional intervention period group, and eight females and 16 males (5–51, mean 25.2, SD 12.9, median 26.5 years) were in the post-nutritional intervention period group. The post-nutritional intervention period group showed significantly higher food intake (p = 0.015) and lower total infusion (p = 0.006) than the pre-nutritional intervention period group. Conclusion: The nutritional intervention increased food intake and also reduced the total amount of intravenous infusion. To identify the cut-off day to cease the intervention and to evaluate whether the intervention can reduce the complication rate, a multicenter study with a large number of patients is warranted.

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Home Total Parenteral Nutrition for Intestinal Failure in Patients with Advanced Small Intestinal Neuroendocrine Neoplasms

Cited by 4 publications

References 21 publications

Feasibility of Home Parenteral Nutrition in Patients with Intestinal Failure Due to Neuroendocrine Tumours: A Systematic Review

Feasibility of Home Parenteral Nutrition in Patients with Intestinal Failure Due to Neuroendocrine Tumours: A Systematic Review

Parenteral Nutrition in Advanced Cancer: The Healthcare Providers’ Perspective

Nutritional Intervention Facilitates Food Intake after Epilepsy Surgery

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