Home-quarantine during the initial Covid-19 outbreak in Israel: parent perceived impact on children with ASD

Arazi, Ayelet; Koller, Judah; Zachor, Ditza A.; Golan, Ofer; Sadaka, Yair; Eytan, Dganit; Stolar, Orit; Atzaba‐Poria, Naama; Golan, Hava M.; Menashe, Idan; Meiri, Gal; Gabis, Lidia V.; Dinstein, Ilan

doi:10.1016/j.heliyon.2022.e09681

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…This 8% prevalence of melatonin treatment in children with ASD is slightly higher than the 3.8% melatonin usage reported in a previous study in the same population, 36 but is similar to the reported usage of melatonin in two meta-analyses. 29,38 Such a relatively low prevalence of melatonin usage stands in contrast to the >50% prevalence of sleep disturbances reported in children with ASD 1,2,4,37 and is especially surprising in light of the significant effects of melatonin on the sleep quality and daytime behavior in these children, as is evident in our study and others. 20,22 One possible explanation for this enigma lies in the concerns of some pediatricians about the side effects of and tolerance to melatonin, which may discourage them to recommend its use.…”

Section: Discussioncontrasting

confidence: 62%

“…The questionnaire (which is presented in Supplementary file 1, available online) comprised two parts: 1) eight questions, adopted from other questionnaires, 27,28 that include details about melatonin dosages, usage patterns (time and frequency), duration of treatment, reason for stopping or continuing treatment, side effects, and source of the medicine; and 2) eight questions that were designed to assess the child's sleep and general daily functioning and behavior, on a scale of 1 to 5 (1 -major negative effect; 2 -minor negative effect; 3 -no effect; 4 -minor positive effect; and 5 -major positive effect), as described previously. [27][28][29] Sociodemographic, behavioral, and clinical data about participating children were obtained from the ANCAN database. Clinical variables included the Autism Diagnostic Observation Schedule™, Second Edition (ADOS®-2) 30 comparison score, the DSM-5 ASD severity levels, the preschool language scale, fourth edition (PLS4) total score, 31 a cognitive score based on either the Bayley Scales of Infant and Toddler Development-third edition (Bayley-III) 32 or the Wechsler Preschool and Primary Scale of Intelligence-version three (WPPSI-III), 33 The General Adaptive Composite (GAC) score of the Adaptive Behavior Assessment System-II (ABAS-II) 34 , and data about the child's sleep quality based on the Children's Sleep Habits Questionnaire (CSHQ).…”

Section: Data Collectionmentioning

confidence: 99%

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Real-life course and effectiveness of melatonin treatment for sleep disturbances in children with autism spectrum disorder

Sadeh,

Meiri,

Zigdon

et al. 2023

Preprint

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Objective: Melatonin is considered the most effective pharmacological treatment for the sleep disturbances that are reported in >50% of children with autism spectrum disorder (ASD). However, real-life data about the long-term course and effectiveness of melatonin treatment in children with ASD is lacking. Methods: In this retrospective cohort study, we assessed the adherence to melatonin treatment and its effect on sleep quality and daytime behavior in children with ASD via a parental phone questionnaire of children in the Azrieli National Center for Autism and Neurodevelopment Research (ANCAN) database. Cox regression analysis was used to assess the effect of key demographic and clinical characteristics on treatment adherence. Results: Melatonin was recommended for ~8% of children in the ANCAN database. These children were characterized by more severe autistic symptomatology. The median adherence time for melatonin treatment exceeded 88 months, with the most common reason for discontinuation being a lack of effectiveness (14%). Mild side-effects were reported in 14% of children, and 86%, 54%, and 45% experienced improvements in sleep onset, sleep duration and night awakenings, respectively. Notably, melatonin also improved the daytime behaviors of >28% of the children. Adherence to treatment was independently associated with improvements in night awakenings and educational functioning (aHR=0.142, 95%CI=0.036-0.565; and aHR=0.195, 95%CI=0.047-0.806, respectively). Conclusions: Our findings highlight the real-life safety and effectiveness of melatonin treatment in children with ASD. Increasing the awareness of this treatment among families and health providers will help to reduce the burden associated with sleep disturbances in children with ASD and their families.

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Section: Discussioncontrasting

confidence: 62%

Section: Data Collectionmentioning

confidence: 99%

Real-life course and effectiveness of melatonin treatment for sleep disturbances in children with autism spectrum disorder

Sadeh,

Meiri,

Zigdon

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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“…Studies have demonstrated that disease-related disasters and quarantine for ASD can increase the risk of PTSD ( Sprang and Silman, 2013 ; Cénat et al ., 2021 ). During the COVID-19 pandemic, individuals with ASD exhibited increased sleep difficulties, aberrant behaviors, irritability, tantrums, anxiety and lethargy ( Arazi et al ., 2022 ; Hall et al , 2023 ). Childhood sexual abuse has been found to impact brain function in adults with ASD, as evidenced by altered event-related potential components and P300 amplitudes ( Okazaki et al ., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder

Song,

Zhao,

Baranova

et al. 2024

Psychiatric Genetics

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Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two neurodevelopmental disorders that often result in individuals experiencing traumatic events. However, little is known about the connection between ADHD/ASD and post-traumatic stress disorder (PTSD). This study aimed to investigate the genetic associations between these disorders. Methods Genetic correlation analysis was used to examine the genetic components shared between ADHD (38 691 cases and 275 986 controls), ASD (18 381 cases and 27 969 controls) and PTSD (23 212 cases and 151 447 controls). Two-sample Mendelian randomization analyses were employed to explore the bidirectional causal relationships between ADHD/ASD and PTSD. Results The results of the genetic correlation analysis revealed significant positive correlations of PTSD with ADHD(rg = 0.70) and ASD (rg = 0.34). Furthermore, the Mendelian randomization analysis revealed that genetic liabilities to ADHD [odds ratio (OR) = 1.14; 95% confidence interval (CI), 1.06–1.24; P = 7.88 × 10−4] and ASD (OR = 1.04; CI, 1.01–1.08; P = 0.014) were associated with an increased risk of developing PTSD later in life. However, no evidence supported that genetic liability to PTSD could elevate the risk of ADHD or ASD. Conclusion The findings of this study supported that ADHD and ASD may increase the risk of PTSD, but not vice versa.

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“…Low-income families were hopeful about receiving benefits through future online services [60]. Despite the many difficulties experienced by parents of children with ASD during home isolation, it can be concluded that the COVID-19 pandemic may be an opportunity to practice parenting skills, improve the quality of communication, or strengthen family ties [61].…”

Section: Diagnostic and Therapeutic Innovations Useful During Isolationmentioning

confidence: 99%

How to Make the Unpredictable Foreseeable? Effective Forms of Assistance for Children with Autism Spectrum Disorder (ASD) during the COVID-19 Pandemic

et al. 2023

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Symptomatology in patients with the diagnosis of autism spectrum disorder (ASD) is very heterogeneous. The symptoms they present include communication difficulties, behavior problems, upbringing problems from their parents, and comorbidities (e.g., epilepsy, intellectual disability). A predictable and stable environment and the continuity of therapeutic interactions are crucial in this population. The COVID-19 pandemic has created much concern, and the need for home isolation to limit the spread of the virus has disrupted the functioning routine of children/adolescents with ASD. Are there effective diagnostic and therapeutic alternatives to limit the consequences of disturbing the daily routine of young patients during the unpredictable times of the pandemic? Modern technology and telemedicine have come to the rescue. This narrative review aims to present a change in the impact profile in the era of isolation and assess the directions of changes that specialists may choose when dealing with patients with ASD.

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Home-quarantine during the initial Covid-19 outbreak in Israel: parent perceived impact on children with ASD

Cited by 8 publications

References 45 publications

Real-life course and effectiveness of melatonin treatment for sleep disturbances in children with autism spectrum disorder

Real-life course and effectiveness of melatonin treatment for sleep disturbances in children with autism spectrum disorder

Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder

How to Make the Unpredictable Foreseeable? Effective Forms of Assistance for Children with Autism Spectrum Disorder (ASD) during the COVID-19 Pandemic

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