Home Outdoor NO2 and New Onset of Self-Reported Asthma in Adults

Jacquemin, Bénédicte; Sunyer, Jordi; Forsberg, Bertil; Aguilera, Inmaculada; Briggs, David; García-Esteban, Raquel; Götschi, Thomas; Heinrich, Joachim; Järvholm, Bengt; Jarvis, Déborah; Vienneau, Danielle; Künzli, Nino

doi:10.1097/ede.0b013e3181886e76

Cited by 65 publications

(76 citation statements)

References 38 publications

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“…However, a ''high score'' phenotype has been shown to be particularly strongly associated with doctordiagnosed asthma [18]; thus our related finding may indicate a role of pollution in new onset of asthma in adults. This interpretation is consistent with our previous finding based on the more traditional definition of ''asthma incidence'', using asthma at follow-up among those free of the disease at baseline [16]. That latter approach is less ambiguous in the interpretation regarding acute and chronic effects as a ''doctor's diagnosis'' does reflect a ''chronic condition'' rather the accumulated acute expression of the disease.…”

Section: Discussionsupporting

confidence: 89%

“…In that previous work, we used the dichotomised definition of new onset of doctor-diagnosed asthma. An increase of 10 mg?m [16]. The use of the dichotomous definition, however, presented limitations that could be overcome with the score.…”

Section: Discussionmentioning

confidence: 99%

“…The European Community Respiratory Health Survey (ECRHS) has found a positive association between NO 2 and asthma incidence in adulthood [16]. In that analysis, ''asthma incidence'' was defined in the traditional way, assuming asthma to be a well-defined dichotomous phenotype with a specified time of onset (''doctor-diagnosed asthma'').…”

mentioning

confidence: 99%

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Association between modelled traffic-related air pollution and asthma score in the ECRHS

Jacquemin¹,

Sunyer²,

Forsberg³

et al. 2009

European Respiratory Journal

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The aim of our analysis was to study the association between air pollution and asthma among adults. For this goal, a previously developed ''asthma score'' was used.Persons aged 25-44 yrs were randomly selected (1991)(1992)(1993) and followed up (2000)(2001)(2002) within the European Community Respiratory Health Survey (ECRHS I and II, respectively). The asthma score was defined from 0 to 5, based on the positive answers to the following symptoms reported for the last 12 months: wheeze/breathlessness, chest tightness, dyspnoea at rest, dyspnoea after exercise and woken by dyspnoea. Participants' home addresses were linked to outdoor modelled NO 2 estimates for 2001. Negative binomial regression was used to model the asthma score.The score from ECRHS II was positively associated with NO 2 (ratio of the mean asthma score (RMS) 1.23, 95% CI 1.09-1.38, for an increase of 10 mg?m -3 ). After excluding participants with asthma and symptoms at baseline, the association remained (RMS 1.25, 95% CI 1.05-1.51), and was particularly high among those reporting a high score in ECRHS II. The latter probably reflects incident cases of asthma.Our results suggest that traffic-related pollution causes asthma symptoms and possibly asthma incidence in adults. The asthma score offers an alternative with which to investigate the course and aetiology of asthma in adults.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Association between modelled traffic-related air pollution and asthma score in the ECRHS

Jacquemin¹,

Sunyer²,

Forsberg³

et al. 2009

European Respiratory Journal

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“…These chemicals are irritating and the authors interpret their results as not being caused by sensitising agents (MedinaRamon et al 2005). Also the relatively low level of ambient irritating air pollution from traffic exhausts in cities in Sweden (Modig et al 2009) and 14 other cities in the European Community (Jacquemin et al 2009) give an excessive risk for asthma.…”

Section: Introductionmentioning

confidence: 99%

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Graff¹,

Fredrikson²,

Jonsson³

et al. 2011

Int Arch Occup Environ Health

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Non-sensitising air pollution at workplaces and adult onset asthma -2- AbstractPurpose This case-control study was undertaken to elucidate the controversy concerning whether low level, long-term exposure to non-sensitising air pollution at workplaces may cause asthma.Methods A case-control study of 192 adult onset asthma cases aged 20 -65 years and 323 controls was conducted in the southeast of Sweden. Cases were identified from computerised registers from the region, diagnosed 2000-2004 and diagnoses were confirmed via medical files. Referents were randomised from the population register of the region. Exposure was monitored by a 16-page questionnaire. Special attention was devoted to identifying and in the final analyses excluding subjects exposed to sensitising agents.Results Three years or more of occupational exposure to air pollution from dust, smoke, fumes or vapours before the year of diagnosis by analyses adjusting for age yielded an increased risk for asthma (OR =2.3, 95 % CI 1.2-4.2) in males, while in females no risk was seen. In a multiple logistic regression analysis in males without allergy in childhood, a significant risk was seen (OR=2.8, 95 % CI 1.07 -7.4), when subjects exposed to identified allergens were excluded. In females no excess risk was observed from occupational air pollution. ConclusionThe results of this study support an association between occupational exposure to low level non-sensitising air pollution and adult onset asthma in males.Non-sensitising air pollution at workplaces and adult onset asthma -3-

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“…The Respiratory Health in Northern Europe study 55 and the European Community Respiratory Living close to high traffic was non-significantly associated with asthma incidence NO 2 was associated with adult asthma incidence only in subjects with a positive SPT Modig et al 55 Cohort in Sweden, including 3,824 adults (age, 15-45), followed-up for 9 years. NO 2 dispersion models and proximity to traffic NO 2 exposure and living close to a major road were associated with asthma onset and incidence in adults Jacquemin et al 56 Prospective cohort, in European 17 cities (ECRHS), including 4,185 adults (age, 20-40) followed up for 10 years. NO 2 dispersion models NO 2 was associated with asthma incidence in adults Kunzli et al 57 Prospective cohort in 8 Swiss areas, including 2,725 adults (age,18-60), followed up for 10 years, traffic-related PM 10 dispersions model Traffic PM 10 is associated with asthma incidence in adult nonsmokers…”

Section: Asthma Incidence In Adultsmentioning

confidence: 99%

Asthma and Air Pollution. Where Are We?

Jacquemin¹,

Sunyer²

2015

BRN

Self Cite

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REVIEW ARTICLE BRN Reviews PERMANYERwww.permanyer.com www.brn.cat BRN Rev. 2015;1:78-91 ABSTRACT Asthma incidence and prevalence have increased in the last decades, suggesting a role of environmental factors including air pollution. In this manuscript, we summarize the evidence of the role of air pollution on (i) asthma exacerbations, (ii) asthma incidence in children, and (iii) asthma incidence in adults, pointing out the most important publications in each of these three areas. There is solid evidence that air pollution causes asthma exacerbations, characterized by hospital admissions, emergency department or doctor's visits, medication intake, or absenteeism. The evidence regarding the effect of long-term air pollution exposure on asthma onset is also quite robust. In children, many studies have associated air pollution or proximity to traffic with asthma incidence, and while there are some negative publications, the evidence for an association is appealing. In adults, several studies also point to a positive association between air pollution and asthma incidence. Furthermore, there is a lot of knowledge about the mechanisms of the different agents involved. Gases, that are oxidants, could be more associated with acute manifestations of the disease and particles, more related with chronic inflammation, could be more associated with incidence. Diesel particles have been associated with both exacerbations and incidence. However, research is still needed to better understand and identify the underlying mechanisms related to the specific pollutants and specific sources. More research is also needed to identify more susceptible groups such as males, non-smokers, or persons with another chronic condition such as atopy or obesity. Corresponding author: Bénédicte Jacquemin, bjacquemin@creal.cat

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Home Outdoor NO2 and New Onset of Self-Reported Asthma in Adults

Abstract: We found an association between a marker of traffic-related air pollution and asthma incidence in European adults.

Cited by 65 publications

References 38 publications

Association between modelled traffic-related air pollution and asthma score in the ECRHS

Association between modelled traffic-related air pollution and asthma score in the ECRHS

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Asthma and Air Pollution. Where Are We?

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