Home Cultures as an Aid in the Diagnosis of Streptococcal Respiratory Infection

Bf, Massell; Amezcua, Jacqueline; Jg, Michael

doi:10.1056/nejm196409172711201

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Based on previous streptococcal research we were confident parents could be trained to collect an adequate respiratory specimen from an ill child without ongoing supervision [16][17][18][19]. We believe parent-collected specimens are a simple and efficient means of conducting future community-based epidemiological, costing, and vaccine and therapeutics efficacy studies.…”

Section: Discussionmentioning

confidence: 99%

Parent-collected respiratory specimens—A novel method for respiratory virus and vaccine efficacy research

Lambert

Allen

Nolan

2008

Vaccine

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Population-based respiratory research and vaccine efficacy studies have previously required clinic or home visits when a subject had an acute respiratory illness. This method may mean parents are unwilling to enroll their child or report an illness of interest. We conducted a community-based cohort study into respiratory illnesses in 234 pre-school aged children using parent-collected specimens. Between January 2003 and January 2004 there were 563 specimens collected from 730 identified illnesses and these were tested using a panel of respiratory virus polymerase chain reaction (PCR) assays; 409 (73%) were positive for any virus. Specimens were not more likely to be positive when collected by a healthcare worker parent, when they included a throat swab, or when a very good collection technique was reported. A delay from illness onset to specimen collection of up to 5 days did not appear to impact on sensitivity of virus identification, but a delay of six or more days with minor delays in testing saw positivity fall. Combined with daily symptom diary completion and PCR testing, parent-collected specimens are an efficient and acceptable method for the conduct of future vaccine efficacy studies and other community-based respiratory virus research.

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Section: Discussionmentioning

confidence: 99%

Parent-collected respiratory specimens—A novel method for respiratory virus and vaccine efficacy research

Lambert

Allen

Nolan

2008

Vaccine

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Treatment of Group A Streptococcal Infections

Honikman¹,

Massell²,

Goodell³

et al. 1969

Am J Dis Child

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Streptococcal Pharyngitis

Randolph¹,

Redys²,

Cope³

et al. 1976

Am J Dis Child

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One hundred sixty-eight children with upper respiratory infections were screened for beta-hemolytic streptococcal pharyngitis. A recently developed throat culture kit was processed in comparison with the conventional blood agar plate using a duplicate swab technique. Kits and plates were examined independently. Three individuals with no previous bacteriologic experience were allowed to interpret results of the culture kit after receiving instructions for approximately 15 minutes on three consecutive days. The interpretations of two of these individuals approached 95% accuracy, and those of the third individual surpassed this rate. The kit appears to be at least equal to the conventional blood agar plate in supporting the growth of beta-hemolytic streptococci. Moreover, its selective nature allows the nontechnical office staff to interpret results of the cultures promptly and accurately with a minimum of instruction.

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Home Cultures as an Aid in the Diagnosis of Streptococcal Respiratory Infection

Cited by 6 publications

References 7 publications

Parent-collected respiratory specimens—A novel method for respiratory virus and vaccine efficacy research

Parent-collected respiratory specimens—A novel method for respiratory virus and vaccine efficacy research

Treatment of Group A Streptococcal Infections

Streptococcal Pharyngitis

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