Home chemical and microbial transitions across urbanization

McCall, Laura Isobel; Callewaert, Chris; Zhu, Quanyin; Song, Se Jin; Bouslimani, Amina; Minich, Jeremiah J.; Ernst, Madeleine; Ruiz-Calderón, Jean F.; Cavallín, Humberto; Pereira, Henrique; Novoselac, Atila; Hernandez, Jean N.; Rios, Rafael A.; Branch, Ora Lee H.; Blaser, Martin J.; Paulino, Luciana Campos; Dorrestein, Pieter C.; Knight, Rob; Domínguez-Bello, María Gloria

doi:10.1038/s41564-019-0593-4

Cited by 104 publications

(122 citation statements)

References 41 publications

(46 reference statements)

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“…Additionally, infants living in suburban areas, with significantly higher relative abundance of Candida and Aspergillus , showed higher mycobiome alpha diversity than did those living in urban areas (generally considered to have a higher level of hygiene). Although this is contrary to a previous report ( McCall et al, 2020 ), there are some studies that support the notion that human hygiene may reduce skin bacterial diversity ( Council et al, 2016 ; Ross et al, 2018 ; McCall et al, 2020 ). The environment accessible to infants (aged 0–6 months in this study) is significantly different from that of humans of other age categories, and this may cause differences in the effect of urbanization on mycobiome.…”

Section: Discussioncontrasting

confidence: 99%

Dynamics of Skin Mycobiome in Infants

et al. 2020

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Understanding the microbial community structure of the human skin is important for treating cutaneous diseases; however, little is known regarding skin fungal communities (mycobiomes). The aim of the present study was to investigate the features of and variations in skin fungal communities during infancy in 110 subjects less than 6 months of age. Skin samples were obtained from the back, antecubital fossa, and volar forearm, while physiological parameters including transepidermal water loss, pH, surface moisture, and deep layer hydration were evaluated. Skin fungal diversity decreased after the first three months of life. Differences in fungal community composition were greater among individual infants than among the three skin sites in the same individual. Inter- and intra-individual variation were similar and lower, respectively, than the variability between two samples obtained 12 weeks apart, from the same site in the same subject, suggesting low stability of fungal communities on infant skin. Skin physiological parameters showed little correlation with skin fungal community structure. Additionally, Malassezia was the most represented genus (36.43%) and M. globosa was the most abundant species in Malassezia with its abundance decreasing from 54.06% at 0–2 months to 34.54% at 5–6 months. These findings provide a basis for investigating the causative fungi-skin interactions associated with skin diseases.

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Section: Discussioncontrasting

confidence: 99%

Dynamics of Skin Mycobiome in Infants

et al. 2020

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“…Some reservations have to be taken into account when interpreting the results of our review. For example, some health benefits of second homes may also come from decreased exposure to common risk factors of modern life, such as daily chemicals, and not just from increased exposure to a green environment [ 93 ]. These inversely correlated features can be hard to disentangle.…”

Section: Discussionmentioning

confidence: 99%

How do Rural Second Homes Affect Human Health and Well-being? Review of Potential Impacts

Pitkänen

Lehtimäki

Puhakka

2020

IJERPH

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Contact with nature is associated with numerous psychological, physiological and social health and well-being benefits. Outdoor recreation, such as rural second home tourism, provides extensive exposure to the natural environment, but research around health impacts of this exposure is scattered. We review current research on health and well-being impacts of nature and discuss how the characteristics of rural second home environments and their use and users can affect these potential impacts in Finland. We discover four key issues affecting the impacts. First, health and well-being impacts depend on the users; urban people can especially benefit from rural second homes, while child development and the performance of elderly people can also be supported by contact with nature at second homes. Second, the regularity, length and season of second home visits influence the potential to receive benefits as they have an impact on the intensity of nature exposure. Third, the type and quality of second home environment affect contact with nature, such as exposure to health-supporting environmental microbes. Fourth, practices, motives and meanings modify activities and attachment and crucially affect both physical and mental well-being. We conclude that rural second homes have extensive potential to provide nature-related health and well-being benefits and further research is needed.

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“…These are likely to represent runoff from activities specific to the corresponding household, or to each household's specific gardening practices. As such, they may represent a fingerprint of household behavior, reminiscent of prior metabolomics studies of the built environment [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Local Phenomena Shape Backyard Soil Metabolite Composition

et al. 2020

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Soil covers most of Earth’s continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil microorganisms. However, the study of the soil small molecule profile has been challenging due to the complexity and heterogeneity of this matrix. In this study, we implemented high-resolution liquid chromatography–tandem mass spectrometry and large-scale data analysis tools such as molecular networking to characterize the relative contributions of city, state and regional processes on backyard soil metabolite composition, in 188 soil samples collected from 14 USA States, representing five USA climate regions. We observed that region, state and city of collection all influence the overall soil metabolite profile. However, many metabolites were only detected in unique sites, indicating that uniquely local phenomena also influence the backyard soil environment, with both human-derived and naturally-produced (plant-derived, microbially-derived) metabolites identified. Overall, these findings are helping to define the processes that shape the backyard soil metabolite composition, while also highlighting the need for expanded metabolomic studies of this complex environment.

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Home chemical and microbial transitions across urbanization

Cited by 104 publications

References 41 publications

Dynamics of Skin Mycobiome in Infants

Dynamics of Skin Mycobiome in Infants

How do Rural Second Homes Affect Human Health and Well-being? Review of Potential Impacts

Local Phenomena Shape Backyard Soil Metabolite Composition

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