Mosquito-borne disease transmission takes place away from places where people enjoy protection from long lasting insecticide treated nets (LLINs) or other control measures due to human and vector behaviours that promote contact between man and vector mosquitoes outside the safe havens of LLINs and other protections against mosquitoes bites. Thus, the study on peri-urban dwellers nocturnal activities and strategies for self-protection against human-vector contact in Mararraba-Akunza, Lafia, Nasarawa State, Nigeria was carried out between December 2016 and January 2017. A well-structured questionnaire on human nocturnal activities that predisposes them to mosquitoes bites was administered to 30 randomly selected households. Result obtained showed that most people sleep outdoor during the hot months between January and March 63.3% (19/30) and thus there was a very high significant difference (P < 0.0001) in relation to the proportion of sleepers between in-and-outdoor points. Almost all respondents 96.67% (29/30) when resting outdoors use a form of protection against mosquito bite. The main outdoor activity that predisposes the people to mosquitoes bites was watching television. Thus, there was a high significant variation (P < 0.01) across predisposing outdoor activities. Also, the proportion of outdoor sleepers across the four quarters of the year highly varied significantly (P < 0.0001). Almost all respondents 70% (21/30) sleep till daybreak and majority of them use insecticide outdoors 43.33% (13) but when indoors most of them sleep under LLINs 66.7% (20/30). The outdoor nocturnal activities of people in the study community will continually expose them to mosquito vectors bites due to high temperature of the lowland area which can only be supported through provision of stable electrical power supply in order for the periurban inhabitants to remain indoors at night. Also, LLINs should be made available to the inhabitants, and they in turn should ensure it is hung outdoor especially during the dry season period so as to avoid contact with mosquitoes.