Home-based exercise training influences gut bacterial levels in multiple sclerosis

Mokhtarzade, Motahare; Shamsi, Mahdieh Molanouri; Abolhasani, Maryam; Bakhshi, Bita; Sahraian, Mohammad Ali; Quinn, LeBris S.; Negaresh, Raoof

doi:10.1016/j.ctcp.2021.101463

Cited by 25 publications

(33 citation statements)

References 38 publications

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“…After the exclusion of 228 irrelevant studies, we identified 36 potentially eligible studies. We checked the full text of these studies, and finally, 11 original clinical trials met the criteria to be included in the meta-analysis [ 51 – 61 ]. No further studies that were appropriate for inclusion were identified via hand searching and checking references.…”

Section: Resultsmentioning

confidence: 99%

“…The cumulative number of female and male participants was 74 and 9, respectively [ 52 , 55 , 56 , 61 ]. Three studies reported the EDSS score of the patients ( n = 58) [ 52 , 60 , 61 ], and the combined EDSS mean ± SD was 2.25 ± 1.16. One study reported the disease duration time of the participants [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies reported the EDSS score of the patients ( n = 58) [ 52 , 60 , 61 ], and the combined EDSS mean ± SD was 2.25 ± 1.16. One study reported the disease duration time of the participants [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

“…In three studies, the levels of TNF-α were compared between PwMS ( N = 62) and controls ( N = 48). The combined mean ± SD of the age of participants was 34.17 ± 7.9 years for 62 reported patients of three studies [ 55 , 60 , 61 ]. The cumulative number of female and male participants was 29 and 6, respectively, reported by two studies [ 55 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

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IL-6 and TNF-α responses to acute and regular exercise in adult individuals with multiple sclerosis (MS): a systematic review and meta-analysis

et al. 2022

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Background In both the general population and people with multiple sclerosis (PwMS), physical exercise is associated with improved mental well-being. Moreover, there is evidence of the possible protection of physical activity against disease progression in multiple sclerosis (MS). However, the question arises if acute or regular exercise has any impact on the immune system in PwMS. To answer this question, we performed a systematic review and meta-analysis on both plasma and serum cytokine levels (IL-6 and TNF-α) before and after acute and regular exercise among PwMS and compared to healthy controls. Method We performed an online search via PubMed, EMBASE, SCOPUS, Web of Science, and Cochrane Library till September 2021 to identify original studies on IL-6 and TNF-α changes after acute and regular exercise in PwMS and controls. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), 11 original studies were included in the meta-analysis. Sensitivity analyses were used to identify the origins of heterogeneity. R 4.0.4 was used to perform the meta-analysis of IL-6 and TNF-α levels before and after acute and regular exercise in PwMS, compared to controls. This study does not qualify for a clinical trial number. Results IL-6 levels did neither increase nor decrease after acute and regular exercise in PwMS, and compared to controls (pre- vs. post-intervention: Standardized Mean Difference (SMD) -0.09, 95% CI [−0.29; 0.11], p-value = 0.37, PwMS vs. Control: SMD −0.08, 95% CI [−0.33; 0.16], p-value = 0.47). In PwMS, TNF-α levels decreased after regular exercise and when TNF-α levels of both acute and regular exercise were pooled (pre- vs. post-intervention: SMD −0.51, 95% CI [-0.91; 0.11], p-value = 0.01, PwMS vs. Control: SMD −0.23, 95% CI [−0.66; 0.18], p-value = 0.26). TNF-α levels did neither increase nor decrease after acute and regular exercise in PwMS, when compared to controls. Conclusion This systematic review and meta-analysis show that exercise does not lead to significant changes in peripheral levels of IL-6 in PwMS in contrast to the observed response in healthy subjects and other medical contexts. However, regular exercise had a specific anti-inflammatory effect on blood TNF-α levels in PwMS. It remains to be investigated why PwMS display this different exercise-induced pattern of cytokines.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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IL-6 and TNF-α responses to acute and regular exercise in adult individuals with multiple sclerosis (MS): a systematic review and meta-analysis

et al. 2022

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“…The effects of exercise on brain function in patients with MS are also promising [ 205 ], including on cognition [ 206 ]. A few studies have investigated the role of the gut microbiota in mediating the beneficial effects of exercise in MS. A study investigating the effect of five sessions of home-based exercise (or no exercise) for 6 months in 42 people with MS showed that the exercise intervention eased anxiety and depression scores as well as modulated the gut microbiota profile, especially towards increasing Prevotella and decreasing Akkermansia muciniphila [ 207 ]. Still, in an animal model of EAE, 4 weeks of strength exercise training before the immunization and 7 days after showed that the exercise intervention increased the gut microbiota abundance and diversity, decreased the Firmicutes/Bacteroidetes ratio, intestinal permeability, and SCFA-producing bacteria, and reduced the T H 17 and Treg immune responses.…”

Section: Exercise and Gut Microbiotamentioning

confidence: 99%

Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders

Gubert

Gasparotto

Morais

2022

Gastroenterology Report

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Recent research has been uncovering the role of the gut microbiota for brain health and disease. These studies highlight the role of gut microbiota on regulating brain function and behavior through immune, metabolic, and neuronal pathways. In this review we provide an overview of the gut microbiota axis pathways to lay the groundwork for upcoming sessions on the links between the gut microbiota and neurogenerative disorders. We also discuss how the gut microbiota may act as an intermediate factor between the host and the environment to mediate disease onset and neuropathology. Based on the current literature, we further examine the potential for different microbiota-based therapeutic strategies to prevent, to modify, or to halt the progress of neurodegeneration.

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The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Li,

Miao,

Liu

et al. 2024

Advanced Science

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Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain–gut–bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing to its profound effects on the occurrence and development of neurodegenerative diseases. No comprehensive review has been conducted to clarify the triangular relationship involving the brain–gut–bone axis and its potential for innovative therapies for neurodegenerative disorders. In light of this, a new perspective is aimed to propose on the interplay between the brain, gut, and bone systems, highlighting the potential of their dynamic communication in neurodegenerative diseases, as they modulate multiple physiological systems, including the nervous, immune, endocrine, and metabolic systems. Therapeutic strategies for maintaining the balance of the axis, including brain health regulation, intestinal microbiota regulation, and improving skeletal health, are also explored. The intricate physiological interactions within the brain–gut–bone axis pose a challenge in the development of effective treatments that can comprehensively target this system. Furthermore, the safety of these treatments requires further evaluation. This review offers a novel insights and strategies for the prevention and treatment of neurodegenerative diseases, which have important implications for clinical practice and patient well‐being.

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Home-based exercise training influences gut bacterial levels in multiple sclerosis

Cited by 25 publications

References 38 publications

IL-6 and TNF-α responses to acute and regular exercise in adult individuals with multiple sclerosis (MS): a systematic review and meta-analysis

IL-6 and TNF-α responses to acute and regular exercise in adult individuals with multiple sclerosis (MS): a systematic review and meta-analysis

Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders

The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

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