Home based care to multi-drug resistant tuberculosis patients: A pilot study

Vaghela, Joyce Felicia; Kapoor, Sorabh; Kumar, Aditi; Dass, Reeti Tewari; Khanna, Ashwani; Bhatnagar, Anuj

doi:10.1016/j.ijtb.2015.04.008

Cited by 7 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with the findings from Uganda where a case report demonstrated successful treatment of MDR-TB using home-based approach as opposed to facility based treatment [7]. Similar higher success rate and lower default rate have been reported in a study done in India [8]. Almost 91% of successful treatment outcome and higher treatment adherence have been reported among home based care recipients in Armania [9].…”

Section: Discussionsupporting

confidence: 89%

Home Based Care as an Approach to Improve the Efficiency of treatment for MDR Tuberculosis: A Quasi-Experimental Pilot Study

Taneja

Chellaiyan

Daral

et al. 2017

JCDR

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Home Based Care as an Approach to Improve the Efficiency of treatment for MDR Tuberculosis: A Quasi-Experimental Pilot Study

Taneja

Chellaiyan

Daral

et al. 2017

JCDR

View full text Add to dashboard Cite

“…Table 1 shows the summary characteristics of the 16 studies included in the meta-analysis. Nine studies [ 6 , 11 , 14 , 30 – 35 ] implemented a community-based intervention while seven studies [ 36 – 42 ] implemented traditional hospitalization. The sample size for each category of patients includes: XDR-TB (29), MDR-TB & XDR-TB (807) and MDR-TB (2508).…”

Section: Resultsmentioning

confidence: 99%

“…Decentralization is achieved by the development of infrastructure for in-patient care at a district level hospital and skills transfer from the specialist referral unit [ 13 ]. Several studies [ 5 , 6 , 14 ] have utilized a mix of interventions for community management of drug resistant tuberculosis (DR-TB) treatment, which includes utilization of family members and healthcare workers to administer DOTS-Plus, social assistance, support groups, routine home visits, and clinician support at the community-based sites.…”

Section: Introductionmentioning

confidence: 99%

Community-based management versus traditional hospitalization in treatment of drug-resistant tuberculosis: a systematic review and meta-analysis

Williams

Makinde

Ojo

2016

glob health res policy

View full text Add to dashboard Cite

BackgroundMultidrug drug resistant Tuberculosis (MDR-TB) and extensively drug resistant Tuberculosis (XDR-TB) have emerged as significant public health threats worldwide. This systematic review and meta-analysis aimed to investigate the effects of community-based treatment to traditional hospitalization in improving treatment success rates among MDR-TB and XDR-TB patients in the 27 MDR-TB High burden countries (HBC).MethodsWe searched PubMed, Cochrane, Lancet, Web of Science, International Journal of Tuberculosis and Lung Disease, and Centre for Reviews and Dissemination (CRD) for studies on community-based treatment and traditional hospitalization and MDR-TB and XDR-TB from the 27 MDR-TB HBC. Data on treatment success and failure rates were extracted from retrospective and prospective cohort studies, and a case control study. Sensitivity analysis, subgroup analyses, and meta-regression analysis were used to explore bias and potential sources of heterogeneity.ResultsThe final sample included 16 studies involving 3344 patients from nine countries; Bangladesh, China, Ethiopia, Kenya, India, South Africa, Philippines, Russia, and Uzbekistan. Based on a random-effects model, we observed a higher treatment success rate in community-based treatment (Point estimate = 0.68, 95 % CI: 0.59 to 0.76, p < 0.01) compared to traditional hospitalization (Point estimate = 0.57, 95 % CI: 0.44 to 0.69, p < 0.01). A lower treatment failure rate was observed in community-based treatment 7 % (Point estimate = 0.07, 95 % CI: 0.03 to 0.10; p < 0.01) compared to traditional hospitalization (Point estimate = 0.188, 95 % CI: 0.10 to 0.28; p < 0.01). In the subgroup analysis, studies without HIV co-infected patients, directly observed therapy short course-plus (DOTS-Plus) implemented throughout therapy, treatment duration > 18 months, and regimen with drugs >5 reported higher treatment success rate. In the meta-regression model, age of patients, adverse events, treatment duration, and lost to follow up explains some of the heterogeneity of treatment effects between studies.ConclusionCommunity-based management improved treatment outcomes. A mix of interventions with DOTS-Plus throughout therapy and treatment duration > 18 months as well as strategies in place for lost to follow up and adverse events should be considered in MDR-TB and XDR-TB interventions, as they influenced positively, treatment success.

show abstract

“…The predicted result shows good plasma protein binding, Blood-Brain Barrier Ames mutagenicity prediction result shows that except compound number 23,24,27,28,29 and 32-50 showing mutagenicity and induces revertant colony growth. Skin sensitization prediction shows compounds other than 12,13,18,19,20,25,26 and 31 are skin nonsensitizer. Overall compounds are predicted to have mild toxicity risk levels.…”

Section: Drug Likeliness In Silico Adme and Toxicity Studymentioning

confidence: 99%

“…There are usually three reasons for needing new antituberculosis drugs: (i) To improve current treatment by shortening the total duration of treatment and/or by providing more widely spaced intermittent treatment [11,12], (ii) To improve the treatment of MDR-TB, and (3) To provide more effective treatment of Latent tuberculosis infection (LTBI) [13].…”

Section: Introductionmentioning

confidence: 99%

Pharmacophore modelling, QSAR study, molecular docking and insilico ADME prediction of 1,2,3-triazole and pyrazolopyridones as DprE1 inhibitor antitubercular agents

Panigrahi¹,

Mishra²,

Sahu

2020

SN Appl. Sci.

View full text Add to dashboard Cite

Tuberculosis (TB) is a chronic lung infected airborne disease caused by Mycobacterium tuberculosis (MTB). The development of resistance towards available antitubercular agents leads to the discovery of new drugs for treatment against these resistant bacteria. Decaprenyl phosphoryl-β-D-Ribose 20-epimerase (DprE1) is a vulnerable target for the design of antitubercular agents which are more acting against multidrug resistant bacterial pathogens. DprE1 is an oxidase involved in the synthesis of arabinogalactan. Inhibition of DprE1 leads to blocking off cell wall synthesis, causing the death of the bacteria. A series of 50 DprE1 inhibitors having activity were subjected to 2D, 3D QSAR, Pharmacophore Modeling, Molecular Docking and in silico ADME studies. Prediction of preliminary Pharmacokinetic and the Drug Likeliness profile was performed for these compounds by in silico ADME study. 2D-QSAR and 3D-QSAR models developed by Partial Least Square associated with the Sphere Exclusion method (PLS-SE) and StepWise variable selection method (SW-kNN MFA) based on k-Nearest Neighbor technique are more significant which have cross-validated squared correlation coefficient (q2), coefficient of determination (r2), Fisher ratio (F) values as 0.7499, 0.8917 and 85.04 and the internal (q2 = 0.8198), external (pred_r2 = 0.6109) model validation correctly predicts activity ~ 81% and ~ 61% for the training and test set, respectively. Pharmacophore model was developed with two aromatic regions (Aro), one aliphatic (Ala) and one hydrogen donor (HDr). Docking studies of the selected inhibitors with the active site of DprE1 enzyme showed hydrogen bond interaction with Gly-116, His-131, Arg-118, Thr-117 and Gln-299 residues present at the active site. The results of the present work provide more useful information and important structural insights for designing DprE1 inhibitors with much more enhanced potency.

show abstract

Home based care to multi-drug resistant tuberculosis patients: A pilot study

Cited by 7 publications

References 10 publications

Home Based Care as an Approach to Improve the Efficiency of treatment for MDR Tuberculosis: A Quasi-Experimental Pilot Study

Home Based Care as an Approach to Improve the Efficiency of treatment for MDR Tuberculosis: A Quasi-Experimental Pilot Study

Community-based management versus traditional hospitalization in treatment of drug-resistant tuberculosis: a systematic review and meta-analysis

Pharmacophore modelling, QSAR study, molecular docking and insilico ADME prediction of 1,2,3-triazole and pyrazolopyridones as DprE1 inhibitor antitubercular agents

Contact Info

Product

Resources

About