Home and Ambulatory Artificial Nutrition (NADYA) Group report: home parenteral nutrition in Spain, 2019

Wanden-Berghe, Carmina; Casas, Nuria Virgili; Compés, C. Cuerda; Boluda, Esther Ramos; Cunill, José Luis Pereira; Jiménez, María Luisa Martín; Peláez, Rosa Burgos; Candela, Carmen Gómez; Lázaro, María Ángeles Penacho; Luis, Daniel Antonio de; Murillo, Ana Zugasti; Faedo, Ceferino Martínez; Hernández, Julia Álvarez; Martín, C. Campos; Rioja-Vázquez, Rosalía; Rocamora, Juan Antonio Irles; Guardiola, Patricia Díaz; París, Alejandro Sanz; Martı́n, Pilar; Pérez, Fátima Carabaña; Folgueras, Tomás Martín; Chinchetru, M a Jesús; Pérez, Luis Miguel Luengo; Costa, Cecilia Martínez; Pérez, Cristina Tejera; Arraiza-Irigoyen, Carmen; Burdiel, Olga Sánchez-Vilar; Delgado, Yaiza García; González, Miguel Ángel Ponce; Roca, Sílvia Mauri; Zafra, María Victoria García; Díaz, María López; López, Jesús Manuel Morán; Baeza, Begoña Molina; Marín, Montserrat Gonzalo; Continente, Alfonso Calañas; Orbáiz, Carmen Garde; Olmos, Miguel; Ortiz, Clara Joaquín; Llanos, José Pablo Suárez; Visa, Maria de Talló Forga; Martinez, Michael A.; Santaliestra, María José Carrera; López, Susana Padín; Lobo, Gabriela; Celaya, Antxón Apezetxea; Sánchez, Carmen Ballesta; Sanjaume, A Bonada; Gaillemin, Bárbara Cánovas; Pera, Daniel Cardona; Puente, Ignacio García; Pulgar, Isabel Higuera; Aranda, Nuria Miserachs; García, María Gutiérrez; Milla, Samara Palma; Marimon, Rosa María Parés i; Maza, Begoña Pintor de la; Martos, Eva Ángeles Sánchez

doi:10.20960/nh.03720

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…This increase is also evident in publications from other countries [ 15 – 19 ]. Reports worldwide have described considerable variability in the prevalence of HPN, ranging from 0.6 to 7.5 per 100,000 inhabitants in more recent reports [ 4 , 20 ]. The Czech Republic has one of the highest prevalence rates, which may be attributed to the comprehensive reimbursement provided by health insurance companies, resulting in high patient numbers and greater access to HPN.…”

Section: Discussionmentioning

confidence: 99%

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The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients’ Data

Koudelková,

Waldauf,

Wohl

et al. 2024

Ann Nutr Metab

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Introduction: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the data collected on HPN patients in the Czech Republic over the past 30 years. Methods: National registry data was collected using a standardised online form based on the OASIS registry (Oley–A.S.P.E.N. Information System) across all centres providing HPN in the Czech Republic. Data collected prospectively from adult patients in the HPN program was analysed in the following categories: epidemiology, demographics, underlying syndrome, and diagnosis, complications, and teduglutide therapy prevalence. Results: The registry identified a total of 1,838 adult patient records, reflecting almost 1.5 million individual catheter days. The prevalence of HPN has risen considerably over the last few decades, currently reaching 5.5 per 100,000 population. The majority of patients have short bowel syndrome and GI obstruction, with cancer being the most prevalent underlying disease. Catheter-related bloodstream infections have been the most prevalent acute complication. However, the incidence in 2022 was only 0.15 per 1,000 catheter days. The study also observed an increase in the prevalence of patients on palliative HPN over the last decade. Conclusion: This study presents a thorough analysis of data from the Czech REDNUP registry. It shows an increasing prevalence of HPN, namely in the palliative patient group. The sharing of national data can improve understanding of this rare condition and facilitate the development of international guidelines.

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Section: Discussionmentioning

confidence: 99%

“…This information is invaluable for healthcare professionals and policy-makers as well as researchers. Although many other countries have already established their registries [ 4 – 8 ], there is still a noticeable lack of published data.…”

Section: Introductionmentioning

confidence: 99%

The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients’ Data

Koudelková,

Waldauf,

Wohl

et al. 2024

Ann Nutr Metab

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“…In 2013, 2016, and 2018, the prevalence of HPN in Spain increased (4.22 vs 6.16 vs 6.61/1 mil. inhabitants) (21,22,23), and the indication of HPN also doubled in the UK in 2015 (40/1 mil. inhabitants) compared to 2005 (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of home parenteral nutrition in malnourished patients

Gazdíková¹,

Fojtova²,

Bátovský³

et al. 2022

BLL

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OBJECTIVE: The goal of our research was to determine the impact of clinical nutrition in the form of home parenteral nutrition (HPN) in patients with nutritional disorders, most often caused by diseases of the digestive tract, with the risk of developing malnutrition. PATIENTS AND METHODS: We retrospectively evaluated 39 patients from the Gastroenterology Clinic and the Home Parenteral Nutrition Center of the University Hospital Bratislava, whose nutritional status was evaluated based on the determination of the body mass index (BMI), the completed nutritional risk screening (NRS) questionnaire and the determination of performance status. Subsequently, after fulfi lling the criteria for HPN, the initiation of parenteral nutrition (PN) followed, implemented in a domestic environment for the following two years as HPN. During this period, we did a monthly check-up of the objective condition and laboratory parameters of the enrolled patients, which were the basis for adjusting the nutritional treatment. We also evaluated the occurrence of infectious and thrombotic complications clinically and on the basis of laboratory parameters focused on culture and hemocoagulation examination. After two years, we performed control exit examinations, which we compared with the entrance examinations and statistically evaluated the success of the treatment. We evaluated the obtained data using standard statistical methods. RESULTS: During HPN, there was a statistically signifi cant elevation of the individual monitored values (BMI, absolute lymphocytes count, cholesterol, cholinesterase, total proteins, albumins), which clearly proves correctly indicated and managed HPN. We recorded vein thrombosis in v. subclavia and v. jugularis in 6 (15 %) patients. Subsequent catheter extraction was necessary after unsuccessful catheter insertion. In 13 (33 %) patients, tunneled catheter replacement was required due to infection. The mortality rate in our group was 8 % (3 patients). These were female patients aged 39, 42, and 66 years. The cause of death in all of these patients was the underlying diagnosis (oncohematological disease, systemic connective tissue disease, and repeated resections of the digestive tract for infl ammatory GIT disease with the development of severe malnutrition). We recorded a positive effect of applied HPN in all three patients until death. We did not register any factors that would have a relevant infl uence on the success of administered HPN. CONCLUSION: Bas ed on our results, we can conclude that the patients included in the HPN were correctly indicated, and all of them, based on the monitored parameters (regardless of gender, age, initial diagnosis, or BMI value), benefi ted from the applied treatment, which was correctly chosen based on their individual needs. Our results clearly document the irreplaceable role of HPN in the management of patients with nutritional intake disorders leading to the development of malnutrition (Tab. 2, Fig. 10, Ref. 44).

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“…SBS is the most frequent pathophysiological mechanism of chronic intestinal failure (IF), defined as the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, necessitating intravenous supplementation to maintain health and/or growth [ 7 ]. The mainstay of the nutritional management of patients with SBS is parenteral nutrition (PN), which can be given either at a hospital (inpatient or outpatient) or at home [ 8 – 10 ]. Patients with chronic IF associated with SBS (SBS-IF) become dependent on long-term PN, which is associated with risk of severe and/or chronic complications, reduced quality of life, and death [ 11 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Etiologies and treatments of chronic intestinal failure-short bowel syndrome (SBS) in Japanese adults: a real-world observational study

et al. 2022

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Purpose Short bowel syndrome (SBS) with intestinal failure (SBS-IF) requires long-term parenteral nutrition (PN). This study investigated the real-world etiologies of SBS, treatment patterns, and PN-related outcomes among adult patients with SBS-IF in Japan. Methods This retrospective, observational cohort study was based on data from April, 2008 to January, 2020 from one of the largest hospital-based claim databases in Japan. Analyzed patients were aged ≥ 16 years, had received continuous PN for ≥ 6 months, and had SBS or undergone SBS-related surgery with a diagnosis of a causative disease. The primary endpoint was PN weaning. Results We analyzed data for 393 patients. The most frequent causes of SBS-IF were ileus (31.8%), Crohn’s disease (20.1%), and mesenteric ischemia (16.0%). Of 144/393 (36.6%) patients who were weaned off their PN, 48 (33.3%) were subsequently restarted on PN. Of 276/393 (70.2%) patients whose PN was initiated in hospital, 156 (56.5%) transitioned to home management. The mean duration of initial PN was 450.4 and 675.5 days for patients who were able or unable to be weaned off PN, respectively. Sepsis (67.4%), catheter-related bloodstream infections (49.1%), and liver disorders (45.0%) were the most reported PN-related complications. Conclusions Most patients with SBS-IF in Japan could not be weaned off PN and suffered life-threatening complications.

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Home and Ambulatory Artificial Nutrition (NADYA) Group report: home parenteral nutrition in Spain, 2019

Abstract: Agradecimientos: a todos los miembros del grupo NADYA por su colaboración desinteresada en mantener activo el registro de pacientes con soporte nutricional a domicilio. Conflictos de intereses: los autores no tienen conflictos de intereses que declarar.

Cited by 5 publications

References 8 publications

The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients’ Data

The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients’ Data

Effect of home parenteral nutrition in malnourished patients

Etiologies and treatments of chronic intestinal failure-short bowel syndrome (SBS) in Japanese adults: a real-world observational study

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