Homage to Reverdin: pinch grafting

Ruiz‐Villaverde, Ricardo; Melguizo, J. Blasco; Ceballos, FJ Delgado; Eisman, Agustín Buendía; Florencio, Vicente Delgado

doi:10.1046/j.1468-3083.2003.00519_11.x

Cited by 5 publications

(4 citation statements)

References 8 publications

(4 reference statements)

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“…Substantial involvement of the nail apparatus may lead to local pain, recurrent infections, and difficulty to perform daily activities as seen in the presented case. Multiple giant KTs affecting all digits are uncommon [16][17][18]. In some patients, these lesions may become keratotic and are often misdiagnosed and mistreated as periungual warts and fibrokeratomas [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple giant KTs affecting all digits are uncommon [16][17][18]. In some patients, these lesions may become keratotic and are often misdiagnosed and mistreated as periungual warts and fibrokeratomas [16][17][18][19]. Squamous-cell carcinoma should be also considered in the differential diagnosis [16].…”

Section: Discussionmentioning

confidence: 99%

“…In some patients, these lesions may become keratotic and are often misdiagnosed and mistreated as periungual warts and fibrokeratomas [16][17][18][19]. Squamous-cell carcinoma should be also considered in the differential diagnosis [16]. Dermoscopy can be helpful for the clinical recognition of ungual fibromas.…”

Section: Discussionmentioning

confidence: 99%

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Giant Koenen Tumors as the Presenting and Only Clinical Sign of Tuberous Sclerosis Complex in a 56-Year-Old Man and Its Surgical Management

Olvera-Rodríguez

Garibay

Domínguez‐Cherit

2022

Skin Appendage Disord

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Introduction: Tuberous sclerosis complex (TSC) is a genetic multisystem disorder with prominent skin involvement. Multiple ungual fibromas, also known as Koenen tumors (KTs), are one of the major diagnostic criteria and occur approximately in 50% of patients with TSC. They are disfiguring, painful, and challenging to treat as they frequently recur. There are 2 previous cases in the literature of KTs as the only clinical sign of TSC. Case Presentation: A 56-year-old male patient with intellectual disability presented with a history of ungual growths that had gradually increased in size and number for 20 years. The diagnosis of KTs was established on clinical grounds, without the requirement of histological confirmation. No additional clinical evidence of TSC was found. Complete surgical excision of the tumors located in the proximal nail matrix, periungual folds, and nail bed of each toe was successfully performed. Discussion: The association between KTs and intellectual disability with TSC supported the clinical diagnosis. To date, there is no standard first-line treatment for KTs. Complete surgical excision up to the proximal base of the tumor offers satisfactory results in terms of functionally and esthetic appearance and could be considered the preferred therapeutic modality for patients with severe functional and cosmetic impairment. Prompt recognition of the many signs and symptoms associated with TSC is important to achieve early diagnosis, preventing further complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Giant Koenen Tumors as the Presenting and Only Clinical Sign of Tuberous Sclerosis Complex in a 56-Year-Old Man and Its Surgical Management

Olvera-Rodríguez

Garibay

Domínguez‐Cherit

2022

Skin Appendage Disord

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“…The practice of applying a multitude of small skin grafts to augment the healing of a larger wound dates back to at least 1869, when Reverdin developed the 'pinch grafting' technique, whereby a small section of skin was pinched, lifted up, then shaved off and grafted into wound sites (Ruiz Villaverde et al , ). This did not include full‐thickness skin, however.…”

Section: Discussionmentioning

confidence: 99%

Reconstitution of full-thickness skin by microcolumn grafting

Tam

Wang

Vuong

et al. 2016

J Tissue Eng Regen Med

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In addition to providing a physical barrier, skin also serves a diverse range of physiological functions through different specialized resident cell types/structures, including melanocytes (pigmentation and protection against ultraviolet radiation), Langerhans cells (adaptive immunity), fibroblasts (maintaining extracellular matrix, paracrine regulation of keratinocytes), sweat glands (thermoregulation) and hair follicles (hair growth, sensation and a stem cell reservoir). Restoration of these functional elements has been a long‐standing challenge in efforts to engineer skin tissue, while autologous skin grafting is limited by the scarcity of donor site skin and morbidity caused by skin harvesting. We demonstrate an alternative approach of harvesting and then implanting μm‐scale, full‐thickness columns of human skin tissue, which can be removed from a donor site with minimal morbidity and no scarring. Fresh human skin microcolumns were used to reconstitute skin in wounds on immunodeficient mice. The restored skin recapitulated many key features of normal human skin tissue, including epidermal architecture, diverse skin cell populations, adnexal structures and sweat production in response to cholinergic stimulation. These promising preclinical results suggest that harvesting and grafting of microcolumns may be useful for reconstituting fully functional skin in human wounds, without donor site morbidity. © 2016 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd.

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