HOMA, QUICKI and MF<SUB>fm</SUB> to Measure Insulin Resistance in Morbid Obesity

Abstract

The high baseline levels of insulin and the high prevalence of hypertension, diabetes or both conditions in patients with central obesity confirm that they suffer a metabolic syndrome, Meanwhile, patients with peripheral obesity with lower levels of chemical parameters and of the metabolic indices suffer peripheral resistance against insulin. Clinical application of these mathematical indices can be useful in patients with MO; they are easily performed and lack the high costs and risks associated with the clamp technique.

Relationship among Adiponectin, Adiponectin Gene Expression and Fatty Acids Composition in Morbidly Obese Patients

“…18 In addition, fasting glucose, insulin, and HOMA index values for both genders were above the cut-off, which could imply that these subjects had increased cardiovascular risk. 13 Plasma adiponectin values were also under those obtained for normalweight populations, especially among men. 19 One of the purposes of the present study was to analyze possible differences in adiponectin gene expression between the two different depots studied (visceral and subcutaneous).…”

Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans

“…These data could be influencing the insulinresistant state of this morbidly obese population. Indeed, the relationship between obesity and insulin resistance has been widely demonstrated (31). In this regard, in this morbidly obese population, both HOMA index and insulin values exceeded the normal range, which indicates that these morbidly obese patients could be classified as insulin-resistant subjects (20).…”

Influence of Waist Circumference on the Metabolic Risk Associated with Impaired Fasting Glucose: Effect of Weight Loss after Gastric Bypass

“…High leukocyte numbers are present in obesity and diabetes, 17,18 a fact that has been associated with the development of CVD, 19 and with vascular complications in T2DM patients. 31 The waist circumference has been shown to exert a strong influence on the development of insulin resistance 5 with smaller waist circumference measurements being an independent predictor of resolution of T2DM after RYGBP. HDL levels (negatively) and TC/HDL (positively) were also significantly correlated with waist circumference.…”