HOMA-AD in Assessing Insulin Resistance in Lean Noncirrhotic HCV Outpatients

Michalczuk, Matheus Truccolo; Kappel, Camila Ripoll; Birkhan, Oscar Augusto; Bragança, Ana Carolina Costa; Álvares‐da‐Silva, Mário Reis

doi:10.1155/2012/576584

Cited by 10 publications

(12 citation statements)

References 46 publications

(54 reference statements)

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“…More recently, a study conducted in the general Japanese population proposed the Homeostasis Model Assessment–Adiponectin (HOMA-AD) index, a modified version of the model, which incorporates the total serum adiponectin level in the denominator of the index and, consequently, it adds an indirect measurement of adiposopathy [ 6 ], and ultimately an adjustment to the individual degree of adiposity. Subsequently, studies with obese children [ 7 ] and with chronic hemodialysis patients [ 8 ] have also identified the good performance of the HOMA-AD index, whereas one study with lean non cirrhotic HCV outpatients did not detect any benefit when comparing the HOMA-AD with the HOMA1-IR [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS)

et al. 2016

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BackgroundThe major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index.ObjectivesTo evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD.Subjects/MethodsThe Brazilian Metabolic Syndrome Study (BRAMS) is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18–65 years old, BMI: 18.5–49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample) and by the hyperglycemic clamp (n = 49). Metabolic syndrome was defined using the IDF criteria.ResultsFor the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64) compared with the HOMA1-IR (r = -0.56); p < 0.0001. In the ROC analysis, compared with the HOMA1-IR, the HOMA-AD showed higher values of the AUC for the identification of IR based on the clamp test (AUC: 0.844 vs. AUC: 0.804) and on the metabolic syndrome (AUC: 0.703 vs. AUC: 0.689), respectively; p < 0.001 for all. However, the pairwise comparison did not show evidence of superiority for the HOMA-AD in comparison with the HOMA1-IR in the diagnosis of IR and metabolic syndrome (p > 0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95.ConclusionsThe HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities.

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Section: Introductionmentioning

confidence: 99%

The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS)

et al. 2016

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“…IR was not associated with fibrosis grade as was observed in studies conducted in HCV patients from Northeast and South regions of Brazil (9,14); this could be because of the small number of patients with an advanced grade of fibrosis that was included in these studies.…”

Section: Discussionmentioning

confidence: 64%

“…In Brazil, IR prevalence varies from 20 to 80% in HCV patients (9)(10)(11)(12)(13). IR was also associated with age, waist circumference, body mass index (BMI), advanced liver fibrosis (10), HCV viral load (14), higher mean degree of steatosis (15) and higher serum levels of oxidative stress (10,11). Although some studies have reported IR prevalence among HCV individuals, the number of subjects is relatively small, and only one or two HCV genotypes were included.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of insulin resistance among Brazilian chronic hepatitis C patients

Villar

Caldas

Scalioni

et al. 2017

Arch. Endocrinol. Metab.

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Objective: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. Subjects and methods: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR. Results: A total of 214 CHC patients were recruited (123 females aged 53.6 years ± 10.9 years). IR was present in 133 patients (62.1%) and was associated in bivariate analysis to higher mean values of age (p = 0.040), triglycerides (p = 0.032), glucose (p = 0.000), insulin (p = 0.000), waist circumference (p = 0.001), and body mass index (p = 0.007); however, none of these variables were significant in the multivariate analysis. Conclusions: The high prevalence of IR was observed among CHC patients, and there was no difference in clinical or laboratory parameters when both groups were compared in the multivariate analysis. This high IR prevalence could lead to a high risk for development of cardiovascular disease and metabolic disorders. Arch Endocrinol Metab. 2017;61(6):628-32

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“…To the best of our knowledge, the present study is the first to assess insulin sensitivity in overweight adults with LBW. HOMA-AD has been evaluated in the pediatric population, individuals with chronic kidney disease and chronic liver disease (36)(37)(38). We also calculated TG/HDL ratio, an alternative, low-cost, useful index for clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Low Birth Weight, β-Cell Function and Insulin Resistance in Adults: The Brazilian Longitudinal Study of Adult Health

et al. 2022

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BackgroundAdverse intrauterine environment—reflected by low birth weight (LBW)—has been linked to insulin resistance and type 2 diabetes later in life. Whether β-cell function reduction and insulin resistance could be detected even in middle-aged adults without overt diabetes is less investigated. We examined the association of LBW with β-cell function and insulin sensitivity in non-diabetic middle-aged adults from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsThis is a cross-sectional analysis of 2,634 ELSA-Brasil participants aged between 34 and 59 years, without diabetes. Participants were stratified according to LBW defined as <2.5 kg and their clinical data were compared. HOMA-IR, HOMA-β, HOMA-adiponectin, TyG index, QUICKI and TG/HDL were calculated and their association with LBW were tested using multiple linear regression including adjustments suggested by Directed Acyclic Graphs and propensity score matching was applied.ResultsThe sample (47.4 ± 6.3 years) was composed of 57.5% of women and 9% had LBW. Subjects with LBW and normal-weight reported similar BMI values at the age of 20 years and current BMI was slightly lower in the LBW group. In average, cardiometabolic risk profile and also indexes of β-cell function and insulin sensitivity were within normal ranges. In regression analysis, log-transformed HOMA-β—but not with the other indexes—was associated with LBW (p = 0.014) independent of sex, skin color, prematurity, and family history of diabetes. After applying propensity-score matching in a well-balanced sample, HOMA-AD and TG/HDL indexes were associated with LBW.ConclusionThe association between LBW and insulin sensitivity markers may occur in healthy middle-aged adults before overt glucose metabolism disturbances. Our data are coherent with the detection of early life events consequent with insulin resistance markers that could contribute to the risk of glucose metabolism disturbances.

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HOMA-AD in Assessing Insulin Resistance in Lean Noncirrhotic HCV Outpatients

Cited by 10 publications

References 46 publications

The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS)

The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS)

High prevalence of insulin resistance among Brazilian chronic hepatitis C patients

Low Birth Weight, β-Cell Function and Insulin Resistance in Adults: The Brazilian Longitudinal Study of Adult Health

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