The aim of this paper is to study modules over Hom-post-Lie algebras and give some contructions and various twistings i.e. we show that modules over Hom-post-Lie algebras are close by twisting either by Hom-post-Lie algebra endomorphisms or module structure maps. Given a type of Hom-algebra A, an A-bimodule M and an O-operator T : A → M , we give construction of another Hom-algebra structure on M .Remark 2.2. If (A, [•, •]) is a non-necessarily associative algebra in the usual sense, we also regard it as the Hom-algebra (A, [•, •], Id A ) with identity twisting map.Definition 2.3. Let (A, [•, •], α) be a Hom-algebra. The Hom-associator of A is the trilinear map as α : A ⊗3 → A defined asDefinition 2.4. A Hom-associative algebra is a triple (A, •, α) consisting of a linear space A, a K-bilinear map • : A × A −→ A and a linear map α : A −→ A satisfying as α (x, y, z) = 0 (Hom-associativity), (2.1) for all x, y, z ∈ A.Definition 2.5. A Hom-module is a pair (M, α M ) in which M is a vector space and α M : M −→ M is a linear map.