Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery

Yang, Dongmei; Kang, Xiaojiao; Ma, Ping’an; Dai, Yunlu; Hou, Zhiyao; Cheng, Ziyong; Li, Chunxia; Lin, Jun

doi:10.1016/j.biomaterials.2012.11.004

Cited by 198 publications

(132 citation statements)

References 58 publications

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“…The results revealed that the cellular uptake of DOX by Hela cells is almost two times as high as non‐modified nanoparticles, which demonstrated the targeted proficiency of designed UCNPs‐based nanocarriers 139. A follow‐on study, where FA is directly grafted onto the surface of hollow, mesoporous structured α‐NaYF 4 :Yb 3+ , Er 3+ UCNPs through amide reaction produced similar results 97. Interestingly, in both studies, the green emission produced by the UCNPs enabled the cell endocytosis process to be monitored.…”

Section: Incorporation Of Targeting Functionality Into Ucnps‐based Ddssmentioning

confidence: 76%

“…On the other hand, PEI ligands can effectively protect the upconverting nanoparticles against acid media, which results in stability enhancement 97. Another outstanding example was reported by Lin's group, who stabilized OA‐capped core−shell structured NaYF 4 :Yb 3+ /Tm 3+ @NaGdF 4 :Yb 3+ nanoparticles using PEI as functional ligands to transfer UCNPs into aqueous phase.…”

Section: Synthesis Of Ucnps‐based Composites For Use In Drug Deliverymentioning

confidence: 99%

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Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

et al. 2016

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The development of drug delivery systems (DDSs) using near infrared (NIR) light and upconversion nanoparticles (UCNPs) has generated intensive interest over the past five years. These NIR‐initiated DDSs not only offer a high degree of spatial and temporal determination of therapeutic release but also provide precise control over the released dosage. Furthermore, these nanoplatforms confer several advantages over conventional light‐based DDSs—NIR offers better tissue penetration depth and a reduced risk of cellular photo‐damage caused by exposure to light at high‐energy wavelengths (e.g., ultraviolet light, <400 nm). The development of DDSs that can be activated by low intensity NIR illumination is highly desirable to avoid exposing living tissues to excessive heat that can limit the in vivo application of these DDSs. This encompasses research in three directions: (i) enhancing the quantum yield of the UCNPs; (ii) incorporation of photo‐responsive materials with red‐shifted absorptions into the UCNPs; and (iii) tuning the UCNPs excitation wavelength. This review focuses on recent advances in the development of NIR‐initiated DDS, with emphasis on the use of photo‐responsive compounds and polymeric materials conjugated onto UCNPs. The challenges that limit UCNPs clinical applications, alongside with the aforementioned techniques that have emerged to overcome these limitations, are highlighted.

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Section: Incorporation Of Targeting Functionality Into Ucnps‐based Ddssmentioning

confidence: 76%

Section: Synthesis Of Ucnps‐based Composites For Use In Drug Deliverymentioning

confidence: 99%

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

et al. 2016

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“…Figure 3A showst he in vitro release profiles of cumulative CUR from hollow NaGdF 4 HMNPs in phosphate-buffered saline (PBS) solutionsatdifferentpH(7.4 and 5.0) at 37 8C; the pH-dependentt rend can be clearly seen. At higherp H, the cationic PEI coating the HMNPs can enhancei ntermoleculari nteractions between CUR and hollow PEI HMNPs, [24] and thus the quantity of CUR molecules in the inner cavity is increased. Figure 3A shows that even in PBS at pH 7.4, just 40 %o fC UR is released fromt he nanocarriers after 48 h. In contrast, the drug is released rapidlya tp H5.0:3 6.5 %w ithin 2h;h owever,a fter 48 h, the amount of released CUR was greater than 60 %.…”

Section: Drug Loading and Release Propertiesmentioning

confidence: 99%

“…At time points established in advance (5 and 10 min, and 0. 5,1,2,4,8,12,24,36, and 48 h), buffer solution was removed (1 mL) and fresh buffer was added back to the system. and 48 h), buffer solution was removed (1 mL) and fresh buffer was added back to the system.…”

Section: Drug Release Propertiesmentioning

confidence: 99%

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

et al. 2017

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To develop a multifunctional nanomaterial for dual‐mode imaging and synergetic chemotherapy, curcumin (CUR) was physically entrapped into hollow upconversion NaGdF4 nanomaterial, then apoferritin (AFn) loaded with doxorubicin (DOX) was attached to the NaGdF4 surface. Subsequent modification with the targeting reagent folic acid (FA) led to generation of the CUR/NaGdF4–DOX/AFn–FA conjugate for cancer treatment. X‐ray diffraction, scanning (SEM) and transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy demonstrated the successful preparation of hexagonal‐phase NaGdF4 and NaGdF4–AFn–FA. Moreover, no toxicity was observed for NaGdF4–AFn–FA. In vitro and in vivo experiments demonstrated that the two drugs are sequentially released from the nanocomposites. This two‐drug system showed strong growth inhibitory effects on MCF‐7 cells. Upconversion luminescence imaging and magnetic resonance (MR) imaging of NaGdF4–AFn–FA were carried out. The results of this study show that NaGdF4–AFn–FA can be used for targeted anticancer drug delivery as well as imaging, a novel multi‐pronged theranostic system for tumor treatment.

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“…At present, different methods have been developed to get upconversion nanophosphors, such as sol-gel [1][2][3][4][5][6][7][8][9], hydrothermal [10][11][12][13][14][15], co-precipitation [16][17][18][19], and thermal decomposition methods [20][21][22][23][24][25][26][27][28][29][30][31][32][33] etc. Nanoparticles synthesized by sol-gel method are usually not suitable for biological applications due to the particle agglomeration in the process of high temperature treatment.…”

Section: Synthesis Of Rare Earth Doped Ucnpsmentioning

confidence: 99%

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

Yang¹,

Han²,

Yue³

2016

Nano BioMed ENG

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As a new generation of fluorophores, up-conversion nanoparticles (UCNPs) exhibit high penetration depth in tissues, low photodamage to biological samples, large Stokes shifts, sharp emission bands, free auto-fluorescence background and high photostability, thus making them an ideal kind of fluorescent labels for a variety of assay formats ranging from bio-imaging to cancer therapy. In this article, the method for the synthesis of biocompatible UCNPs, the recent progress regarding the UCNPs for multimodal targeted tumor imaging, drug delivery, photodynamic therapy (PDT), and photothermal therapy (PTT) are discussed on emphasis. The challenges and opportunities in this emerging field are also presented.

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Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery

Cited by 198 publications

References 58 publications

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

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Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery

Cited by 198 publications

References 58 publications

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

A Hollow NaGdF4/AFn Nanosystem Based on “Relay Race” Release for Therapy

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

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A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy