Hollow SnO2/CdS QDs/CdCO3 heterostructured nanocubes coupled with hollow PtPd/MnCo–CeO2 nanozyme-mediated synergistic amplification for ultrasensitive PEC immunoanalysis of lung cancer biomarker

Zheng, Jia-Ying; Wei, Jing-Jing; Yang, Haiyan; Xu, Fuzong; Yang, Lei; Song, Pei; Wang, Ai‐Jun; Mei, Li-Ping; Zhang, Lu; Feng, Jiu‐Ju

doi:10.1016/j.bios.2023.115398

Cited by 19 publications

(2 citation statements)

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Section: ■ Introductionmentioning

confidence: 99%

“…Photoelectrochemical (PEC) immunoassay, an advanced technique that can convert the target concentration into detectable photocurrent signals, has attractive potential and desirable advantage in sensing analysis. − Due to excellent selectivity, simple devices, and straightforward operation, , PEC immunosensors have gained extensive utilization in the detection of disease markers, , environmental pollutants, and mycotoxins. , Semiconductor photoactive materials are the core of care required in the application of PEC immunosensors. Various semiconductor photoactive materials such as TiO 2 , ZnO, and WO 3 have been used to develop PEC immunosensors. ,, However, these wide band gap photocatalysts mainly absorb high-energy ultraviolet light, which is not conducive to generating strong and stable PEC signals under visible light irradiation.…”

Section: Introductionmentioning

confidence: 99%

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Ternary BiOI/Bi₂S₃/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Xu,

Zhang,

Liu

et al. 2024

Langmuir

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Nanosheet arrays with stable signal output have become promising photoactive materials for photoelectrochemical (PEC) immunosensors. However, an essential concern is the facile recombination of carriers in one-component nanoarrays, which cannot be readily prevented, ultimately resulting in weak photocurrent signals. In this study, an immunosensor using gold nanoparticle-anchored BiOI/Bi 2 S 3 nanosheet arrays (BiOI/Bi 2 S 3 / Au) as a signal converter was fabricated for sensitive detection of cardiac troponin I (cTnI). The ternary nanosheet arrays were prepared by a simple method in which Bi 2 S 3 was well-coated on the BiOI surface by in situ growth, whereas the addition of Au further improved the photoelectric conversion efficiency and could link more antibodies. The three-dimensional (3D) ordered sheet-like network array structure and BiOI/Bi 2 S 3 /Au ternary nanosheet arrays showed stable and high photoelectric signal output and no significant difference in signals across different batches under visible light excitation. The fabricated immunosensor has a sensitive response to the target detection marker cTnI in a wide linear range of 500 fg/mL to 50 ng/mL, and the detection limit was 32 fg/ mL, demonstrating good stability and selectivity. This work not only shows the great application potential of ternary heterojunction arrays in the field of PEC immunosensors but also provides a useful exploration for improving the stability of immunosensors.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ternary BiOI/Bi₂S₃/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Xu,

Zhang,

Liu

et al. 2024

Langmuir

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Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Tian,

Li,

Tang

et al. 2024

Adv Healthcare Materials

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As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared to protein‐based enzymes, nanozymes exhibit attractive characteristics of low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them with wide use from biochemical sensing and environmental remediation to medical theranostics. Especially in biomedical diagnosis, the feature of catalytic signal amplification provided by nanozymes makes them function as emerging labels for the detection of biomarkers and diseases, with rapid developments observed in recent years. To provide a comprehensive overview of recent progress made in this dynamic field, here an overview of biomedical diagnosis enabled by nanozymes is provided. This review first summarizes the synthesis of nanozyme materials and then discusses the main strategies applied to enhance their catalytic activity and specificity. Subsequently, representative utilization of nanozymes combined with biological elements in disease diagnosis is reviewed, including the detection of biomarkers related to metabolic, cardiovascular, nervous, and digestive diseases as well as cancers. Finally, some development trends in nanozyme‐enabled biomedical diagnosis are highlighted, and corresponding challenges are also pointed out, aiming to inspire future efforts to further advance this promising field.

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Construction of functionally specific nanozymes for cancer theragnostic

Salmanoglu,

Karadag,

Odaci

2024

Nanozymes

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Hollow SnO2/CdS QDs/CdCO3 heterostructured nanocubes coupled with hollow PtPd/MnCo–CeO2 nanozyme-mediated synergistic amplification for ultrasensitive PEC immunoanalysis of lung cancer biomarker

Cited by 19 publications

References 59 publications

Ternary BiOI/Bi₂S₃/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Ternary BiOI/Bi₂S₃/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Construction of functionally specific nanozymes for cancer theragnostic

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Hollow SnO2/CdS QDs/CdCO3 heterostructured nanocubes coupled with hollow PtPd/MnCo–CeO2 nanozyme-mediated synergistic amplification for ultrasensitive PEC immunoanalysis of lung cancer biomarker

Cited by 19 publications

References 59 publications

Ternary BiOI/Bi2S3/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Ternary BiOI/Bi2S3/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Construction of functionally specific nanozymes for cancer theragnostic

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Product

Resources

About

Ternary BiOI/Bi₂S₃/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I

Ternary BiOI/Bi₂S₃/Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I