Hollow silica nanoparticles loaded with hydrophobic phthalocyanine for near-infrared photodynamic and photothermal combination therapy

Peng, Juanjuan; Zhao, Lingzhi; Zhu, Xingjun; Sun, Yun; Feng, Wei; Gao, Yanhong; Wang, Liya; Li, Fuyou

doi:10.1016/j.biomaterials.2013.07.027

Cited by 137 publications

(100 citation statements)

References 25 publications

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“…Contrastingly, post-irradiation, the cell viability decreased with increasing microparticle concentration. These results strongly indicate that the microparticles became cytotoxic after being vaporized through laser irradiation, resulting in cancer cell mortality, which is consistent with results reported by other investigators464748.…”

Section: Discussionsupporting

confidence: 92%

Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models

Niu

Wang

et al. 2017

Sci Rep

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Perfluorocarbon (PFC) droplets were studied as new generation ultrasound contrast agents via acoustic or optical droplet vaporization (ADV or ODV). Little is known about the ODV irradiated vaporization mechanisms of PFC-microparticle complexs and the stability of the new bubbles produced. In this study, fluorescent perfluorohexane (PFH) poly(lactic-co-glycolic acid) (PLGA) particles were used as a model to study the process of particle vaporization and bubble stability following excitation in two-dimensional (2-D) and three-dimensional (3-D) cell models. We observed localization of the fluorescent agent on the microparticle coating material initially and after vaporization under fluorescence microscopy. Furthermore, the stability and growth dynamics of the newly created bubbles were observed for 11 min following vaporization. The particles were co-cultured with 2-D cells to form 3-D spheroids and could be vaporized even when encapsulated within the spheroids via laser irradiation, which provides an effective basis for further work.

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Section: Discussionsupporting

confidence: 92%

Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models

Niu

Wang

et al. 2017

Sci Rep

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“…[9][10][11][12][13][14][15] Near-infrared-induced PDT methods that employ special photosensitizers and up-conversion materials have been developed to address limited penetration depth. [16][17][18] However, these efforts remain inadequate for satisfactory progress against deep-seated cancers.…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer-Loaded Branched Polyethylenimine-PEGylated Ceria Nanoparticles for Imaging-Guided Synchronous Photochemotherapy

Yang

Zeng

et al. 2015

ACS Appl. Mater. Interfaces

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A multifunctional theranostic platform based on photosensitizer (chlorin e6, Ce6)-loaded branched polyethylenimine-PEGylated ceria nanoparticles (PPCNPs-Ce6) was created for the development of effective cancer treatments involving the use of imaging-guided synchronous photochemotherapy. PPCNPs-Ce6 with high Ce6 photosensitizer loading (Ce6: cerium ∼40 wt %) significantly enhanced the delivery of Ce6 into cells and its accumulation in lysosomes, remarkably improving photodynamic therapeutic (PDT) efficacy levels compared to those in the administration of free Ce6 at ultralow drug doses (∼200 nM). Interestingly, PPCNPs-Ce6 efficiently induced HeLa cell death even at low concentrations (∼10 μM) without the use of laser irradiation and exhibit chemocytotoxicity. Inductively coupled plasma mass spectrometry (ICP-MS) and biology transmission electron microscopy (Bio-TEM) analyses demonstrated that ceria nanoparticles enter cells abundantly and accumulate in lysosomes or large vesicles. We then evaluated the effects of the different materials on lysosomal integrity and function, which revealed that PPCNPs-Ce6 catastrophically impaired lysosomal function compared to results with PPCNPs and Ce6. Studies of apoptosis revealed greater induction of apoptosis by PPCNPs-Ce6 treatment. This multifunctional nanocarrier also exhibited a high degree of solubility and stability in aqueous solutions, suggesting its applicability for extensive biomedical application.

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“…Various strategies have been explored to enhance the water solubility and overcome aggregation of Pc molecules, including chemical conjugation of them with hydrophilic polymers [9,10], and encapsulation of them into nano- or microcarriers, including micelles [11], liposomes [4], dendrimers [5,12], nanoparticles [13,14], etc. Among these formulas, noncovalent encapsulation of the hydrophobic Pc into carriers, such as macromoleculars and micro-/nanoparticles, is most well received due to the facile manipulation for drug encapsulation, enhanced drug loading efficiency, and preserved intrinsic properties of the carrier [5,7].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy

Liu

Zhang

et al. 2014

Materials

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Phthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., Pc@pNIPAM or Pc@pNIPAM/lipid), to improve its water solubility and prevent aggregation in aqueous medium. The incorporation of lipid molecules significantly enhances the Pc loading efficiency of pNIPAM. These Pc@pNIPAM and Pc@pNIPAM/lipid composite microspheres show thermo-triggered release of Pc and/or lipid due to the phase transition of pNIPAM. Furthermore, in the in vitro experiments, these composite particles work as drug carriers for the hydrophobic Pc to be internalized into HeLa cells. After internalization, the particles show efficient fluorescent imaging and PDT effect. Our work demonstrates promising candidates in promoting the use of hydrophobic drugs including photosensitizers in tumor therapies.

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Hollow silica nanoparticles loaded with hydrophobic phthalocyanine for near-infrared photodynamic and photothermal combination therapy

Cited by 137 publications

References 25 publications

Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models

Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models

Photosensitizer-Loaded Branched Polyethylenimine-PEGylated Ceria Nanoparticles for Imaging-Guided Synchronous Photochemotherapy

Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy

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