Hollow porous implants filled with mesoporous silica particles as a two-stage antibiotic-eluting device

Pérez, Luis Manuel; Lalueza, Patricia; Monzón, Marta; Puértolas, J.A.; Arruebo, Manuel; Santamarı́a, Jesús

doi:10.1016/j.ijpharm.2011.02.015

Cited by 23 publications

(15 citation statements)

References 27 publications

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“…For in vivo implant applications, this might be more favorable, although this phase can be passed through before implantation if lower release concentrations are desired. These results differentiate the current work from previous studies which are predominantly characterized by either a burst release or premature depletion of the compound [18,[27][28][29].…”

Section: Discussioncontrasting

confidence: 57%

“…Up to now, very limited attention has been devoted to the application of drug delivery vehicles in the bulk of metallic implants. For example, porous titanium (Ti) or stainless steel cylinders have been described to serve as a reservoir for drug loaded gelatin sponges or packed beds of mesoporous silica particles, respectively [26][27][28]. Moreover, we have previously synthesized amorphous microporous silica inside an open porous Ti surface coating for the controlled release of chlorhexidine [29].…”

Section: Introductionmentioning

confidence: 99%

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Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Braem

Cremer

Delattin

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Braem

Cremer

Delattin

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…A novel system utilizes antibiotic-loaded reservoirs within the steel implant itself to enable a more controlled, localized release of drug when compared to coatings [63] . Initial in vivo testing by Gimeno et al [64] demonstrated that sheep infected with a biofilm-forming S. aureus strain showed no signs of infection of pre-placed tibia implants 7-9 d post introduction of S. aureus.…”

Section: Antibiotic-loaded Reservoirsmentioning

confidence: 99%

Antimicrobial technology in orthopedic and spinal implants

Eltorai

Haglin

Perera

et al. 2016

WJO

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Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines orthopedic implant antimicrobial technology, its current applications and supporting evidence, and clinically promising future directions.Key words: Antimicrobial; Coated implants; Antibiotic; Antiseptic; Nano-silver; Photoactive Core tip: Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines the latest orthopedic implant antimicrobial technologies-including updates on chitosan

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“…Such cavity allows engaging specific surgery tools or screw-retained fixtures, like healing screws, abutments or crowns. The concept of combining hollow tubular metallic support structures including orifices of 0.2 up to 1.0 mm with various drug-releasing carrier materials inside the internal cavity has been previously suggested, among others for percutaneous orthopaedic implants (Clark et al, 2008;Gimeno et al, 2015;Park et al, 2014;Perez et al, 2011;Santos et al, 2014). The novelty of the current design lies in the fact that the mesoporous controlled release (SiO 2 ) matrix is incorporated in the (Ti) implant walls ( Fig.…”

Section: K De Cremer Et Almentioning

confidence: 99%

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation

Cremer

Braem²,

Gerits³

et al. 2017

eCM

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Roughened surfaces are increasingly being used for dental implant applications as the enlarged contact area improves bone cell anchorage, thereby facilitating osseointegration. However, the additional surface area also entails a higher risk for the development of biofilm associated infections, an etiologic factor for many dental ailments, including peri-implantitis. To overcome this problem, we designed a dental implant composed of a porous titaniumsilica (Ti/SiO 2 ) composite material and containing an internal reservoir that can be loaded with antimicrobial compounds. The composite material consists of a sol-gel derived mesoporous SiO 2 diffusion barrier integrated in a macroporous Ti load-bearing structure obtained by powder metallurgical processing. The antimicrobial compounds can diffuse through the porous implant walls, thereby reducing microbial biofilm formation on the implant surface. A continuous release of µM concentrations of chlorhexidine through the Ti/SiO 2 composite material was measured, without initial burst effect, over at least 10 days and using a 5 mM chlorhexidine solution in the implant reservoir. Metabolic staining, CFU counting and visualisation by scanning electron microscopy confirmed that Streptococcus mutans biofilm formation on the implant surface was almost completely prevented due to chlorhexidine release (preventive setup). Moreover, we demonstrated efficacy of released chlorhexidine against mature Streptococcus mutans biofilms (curative setup). In conclusion, we provide a proof of concept of the sustained release of chlorhexidine, one of the most widely used oral antiseptics, through the Ti/SiO 2 material thereby preventing and eradicating biofilm formation on the surface of the dental implant. In principle, our flexible design allows for the use of any bioactive compound, as discussed.

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Hollow porous implants filled with mesoporous silica particles as a two-stage antibiotic-eluting device

Cited by 23 publications

References 27 publications

Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium

Antimicrobial technology in orthopedic and spinal implants

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation

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