Hollow Polyethyleneimine Nanoparticles with Drug Loaded DNA for Chemotherapeutic Applications
Brendan Rucci,
Brian Boyle,
Mark Byrne
Abstract:The next generation of anticancer agents are emerging from rationally designed nanostructured materials. This work involved the synthesis and characterization of novel hollow DNA‐conjugated gold nanoparticles (DNA‐AuNPs) for controlled drug delivery. Polyethyleneimine (PEI) was bound to AuNPs, forming polymer‐shell nanoparticles. Dissolution of the gold core via iodine formed hollow core polymeric nanoparticles (HCPNPs) and a high density (85 molecules/particle) of DNA intercalated with daunorubicin was conjug… Show more
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