Hollow microneedles: A perspective in biomedical applications

Cárcamo-Martínez, Álvaro; Mallon, Brónach; Domínguez-Robles, Juan; Vora, Lalitkumar K.; Anjani, Qonita Kurnia; Donnelly, Ryan F.

doi:10.1016/j.ijpharm.2021.120455

Cited by 132 publications

(80 citation statements)

References 155 publications

(224 reference statements)

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“…MNs are emerging as a minimally invasive method to enhance ocular drug delivery with no irritation [29]. However, most studies had either used model drugs [44,45] or drug-like pilocarpine [46]. Only one study was published recently, which used liposomal AMP-B, and pure AMP-B encapsulated PVP/PVA MNs to treat ocular fungal infection [35].…”

Section: Discussionmentioning

confidence: 99%

Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections

Albadr

Tekko

Vora

et al. 2021

Drug Deliv. and Transl. Res.

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Chronic fungal infection of the cornea could lead to blindness if not treated properly. Topical amphotericin B (AMP-B) is considered the first treatment of choice for ocular fungal infection. However, factors related to its poor solubility and penetration through intact cornea lead to poor bioavailability. Microneedles (MNs) are emerging as a minimally invasive method to enhance ocular drug delivery. This study aims to investigate the potential use of biodegradable poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA)–based rapidly dissolving MNs for delivery of AMP-B to treat fungal infection. The data obtained illustrates PVP/HA MN arrays’ reproducibility, good mechanical strength, and faster dissolution with 100% drug recovery. Multiphoton microscopic results revealed that MNs successfully penetrate the corneal tissue and enhance AMP-B permeation through corneal layers. Furthermore, PVP/HA MN arrays showed high solubility. Both PVP and HA successfully decreased AMP-B cytotoxicity when compared to free drug. More interestingly, the biocompatible MN formulations preserved the antifungal activity of AMP-B, as demonstrated by significant inhibition of fungal growth. Therefore, this study shows the feasibility of ocular delivery of the poorly soluble AMP-B using a fast-dissolving MN patch. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections

Albadr

Tekko

Vora

et al. 2021

Drug Deliv. and Transl. Res.

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“…A wide variety of materials can be used to make hollow MNs, including silicon, metal, glass, ceramic, and polymers (Fig. 1 ) [ 28 , 29 ]. Polymers with high biocompatibility, such as SU8 polymer [ 30 , 31 ], clay reinforced polyimide, and metal electroplated polymer, have gained interest in recent years.…”

Section: Mns Used For Insulin Transdermal Deliverymentioning

confidence: 99%

Microneedle-based insulin transdermal delivery system: current status and translation challenges

Zhao¹,

Yao³

et al. 2021

Drug Deliv. and Transl. Res.

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“…Solid MNs are usually made up of glass. where, the base layer provides mechanical support and the remaining layers containing the drug deliver therapeutic effect (Cárcamo-martínez et al 2021 ). It shows the advantage of preventing the infection at the site of action with lower therapeutic effect.…”

Section: Classification Of Mns-based On Theranosticsmentioning

confidence: 99%

“…Blockage of the bore of needle tips by skin tissue during insertion has been described as a restriction. This problem can be overcome by retracting the MN array and/or positioning the bore on the MN side (Cárcamo-Martínez et al 2021 ). Furthermore, for the construction of hollow MN arrays, precise manufacturing processes like as lithography, etching, microelectromechanical systems (MEMS), and, more recently, 3D printing are required, all of which are discussed in the next section (Bhatnagar et al 2019 ).…”

Section: Classification Of Mns-based On Theranosticsmentioning

confidence: 99%

“…This is widely used to analyze the blood and ISF for the detection of ions or glucose in the blood or biological fluids and this leads to the delivery of insulin or vaccine are more prominent action. The hollow MNs possess one major drawback wherein the needles are mostly clogged while inserting into the skin (Cárcamo-martínez et al 2021 ). Hollow MNs are used to transport liquids containing soluble compounds such as poly-lactic acid nanospheres and microparticles into the sclera with infusion volumes ranging from 10 to 35 µL (Shende and Salunke 2019 ).…”

Section: Classification Of Mns-based On Theranosticsmentioning

confidence: 99%

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Microneedles in diagnostic, treatment and theranostics: An advancement in minimally-invasive delivery system

Amarnani

Shende

2021

Biomed Microdevices

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Graphical abstract Microneedle (MN) technology plays an important role in biomedical engineering for their less intrusive access to the skin due to minimally or painless penetration, enhancement of drug permeability, improvement of detectability of biomolecules in the epidermal and dermal layers with therapeutic efficacy and safety. Furthermore, MNs possess some major disadvantages like difficulty in scale-up technique, variation in drug delivery pattern with respect to external environment of skin, blockage of arrays due to dermal tissues, induction of inflammation or allergy at the site of administration and restriction of dosing range based on the size of active. Additionally, microneedle acts as a transdermal theranostic device for monitoring the physiological parameters in clinical studies. The investigation of drug transfer mechanisms through microneedles includes coat and poke, poke and flow, poke and patch and poke and release method. This review article discusses different categories of microneedles with fabrication methods such as photolithography, laser cutting, 3D printing, etc. in therapeutic applications for treating cancer, diabetes, arthritis, obesity, neurological disorders, and glaucoma. Biosensing devices based on microneedles may detect target analytes directly in the interstitial fluid by penetrating the stratum corneum of the skin and thus microneedles-based devices can be considered as a single tool in diagnostic sensing and therapeutic administration of drugs inside the body. Moreover, the clinical status and commercial availability of microneedle devices are discussed in this review article to offer new insights to researchers and scientists. Continuous monitoring particularly for the determination of blood glucose concentration is one of the most important requirements for the development of next-generation healthcare devices. The aim of this review article focuses mainly on the theranostic applications of microneedles in various medical conditions such as malaria, glaucoma, cancer, etc.

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Hollow microneedles: A perspective in biomedical applications

Cited by 132 publications

References 155 publications

Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections

Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections

Microneedle-based insulin transdermal delivery system: current status and translation challenges

Microneedles in diagnostic, treatment and theranostics: An advancement in minimally-invasive delivery system

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