Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Groot, Anne Marit de; Du, Guangsheng; Mönkäre, Juha; Platteel, Anouk C.M.; Broere, Femke; Bouwstra, Joke A.; Sijts, Alice J.A.M.

doi:10.1016/j.jconrel.2017.09.017

Cited by 50 publications

(30 citation statements)

References 50 publications

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“…For example, De Groot et al immunized mice using hollow MNA loaded with PLGA nanoparticles containing OVA and poly(I:C). The immune response triggered in the murine model, provided protection against a recombinant strain of the intracellular bacterium Listeria monocytogenes [119]. Inactivated bacteria as a protective agent have also been formulated in MNA.…”

Section: Immunizationmentioning

confidence: 99%

Microneedle-Based Delivery: An Overview of Current Applications and Trends

et al. 2020

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Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.

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Section: Immunizationmentioning

confidence: 99%

Microneedle-Based Delivery: An Overview of Current Applications and Trends

et al. 2020

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“…Lymphatic targeting is beneficial for TCI. Preclinical studies of the delivery of synthetic long peptides, vaccine antigens, synthetic mRNA encoding model antigens or pDNA encoding antigens by hollow microneedles have been reported. Both humoral and protective cellular immune responses were successfully evoked.…”

Section: Advanced Technologies For Transcutaneous Gene Deliverymentioning

confidence: 99%

“…66 Lymphatic targeting is beneficial for TCI. Preclinical studies of the delivery of synthetic long peptides, 67 vaccine antigens, 68…”

Section: Hollow Microneedlesmentioning

confidence: 99%

Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination

Sun

Zeng

Huang

2019

The Journal of Gene Medicine

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Therapeutic vaccination is a promising strategy for the immunotherapy of cancers. It eradicates cancer cells by evoking and strengthening the patient's own immune system. Because of the easy access and sophisticated immune networks, the skin becomes an ideal target organ for vaccination. Genetic vaccines have been widely investigated, with the advantages of the delivery of multiple antigens and a lower cost for production compared to protein/peptide vaccines. This review summarizes the advances made with respect to the transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination and also gives a brief description of the immunological milieu of the skin and the importance of dendritic cell‐targeting in vaccine delivery, as well as the technologies that aim to facilitate antigen delivery and modulate antigen‐presenting cells, thus improving cellular responses. The applications of genetic vaccines encoding tumor antigens delivered through the skin route, both in preclinical and clinical trials, are outlined.

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“…Activation of the inflammasome through cytosolic NOD-like receptors can lead to a self-adjuvant effect by the nanoparticle vehicle itself that promotes adaptive immunity (27)(28)(29). Lastly, nanoparticles containing vaccines can be used to control the duration of delivery through synchronous and sustained release of antigens and adjuvants (30,31).…”

mentioning

confidence: 99%

“…Delivery kinetics can be further modified using strategies such as incorporating nanoparticles into hydrogels or intradermal microneedle delivery systems (30)(31)(32). These sustained release systems can allow for the development of single dose vaccines (33).…”

mentioning

confidence: 99%

The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems

Soni

Bobbala

et al. 2020

Pediatr Res

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Infection is the predominant cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, very young infants fail to respond optimally to most vaccines currently in use, especially neonates. In 2005, Stanley Plotkin proposed that new delivery systems would spur a new revolution in pediatric vaccinology, just as attenuation, inactivation, cell culture of viruses, genetic engineering, and adjuvantation had done in preceding decades. Recent advances in the field of immunoengineering, which is evolving alongside vaccinology, have begun to increasingly influence vaccine formulation design. Historically, the particulate nature of materials used in many vaccine formulations was empiric, often because of the need to stabilize antigens or reduce endotoxin levels. However, present vaccine delivery systems are rationally engineered to mimic the size, shape, and surface chemistry of pathogens, and are therefore often referred to as “pathogen-like particles”. More than a decade from his original assessment, we re-assess Plotkin’s prediction. In addition, we highlight how immunoengineering and advanced delivery systems may be uniquely capable of enhancing vaccine responses in vulnerable populations, such as infants. Impact Immunoengineering and advanced delivery systems are leading to new developments in pediatric vaccinology.Summarizes delivery systems currently in use and development, and prospects for the future.Broad overview of immunoengineering’s impact on vaccinology, catering to Pediatric Clinicians and Immunologists.

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Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Cited by 50 publications

References 50 publications

Microneedle-Based Delivery: An Overview of Current Applications and Trends

Microneedle-Based Delivery: An Overview of Current Applications and Trends

Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination

The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems

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