Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer

Abd-El-Azim, Heba; Tekko, Ismaiel; Ali, Ahlam; Ramadan, Alyaa; Nafee, Noha; Khalafallah, Nawal; Rahman, Taifur; McDaid, William J.; Vora, Lalitkumar K.; Bell, Steven; Furlong, Fiona; McCarthy, Helen; Donnelly, Ryan F.

doi:10.1016/j.jconrel.2022.06.027

Cited by 53 publications

(30 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, their therapeutic efficacy has been substantially hindered due to the hydrophobicity and poor skin permeability. To overcome this issue, Abd-El-Azim and colleagues developed Hy-loaded lipid nanocapsules (Hy@LNs) and further delivered them to the non-melanoma skin cancer site through hollow MN (HMN) to improve the efficacy of localized PDT [ 379 ]. The particle size of developed Hy@LNs was 47 nm with negative zeta potential.…”

Section: Microneedle Patch For Skin Cancer Therapymentioning

confidence: 99%

“…Overall, based on these results, it is witnessed that NPs delivered through MNs could furnish remarkable cutaneous skin cancer therapy than free drug-loaded MNs, free drug-loaded conventional topical/transdermal formulations, and NPs-based conventional topical/transdermal formulations. Nevertheless, the NPs imbibed MNs could deliver the drugs into the systemic circulation to treat metastasized skin cancer by potentially overcoming the drawbacks associated with hypodermic needle-based injections, such as pain and inconvenience [ 379 ].…”

Section: Microneedle Patch For Skin Cancer Therapymentioning

confidence: 99%

See 1 more Smart Citation

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

et al. 2023

View full text Add to dashboard Cite

Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic modification have further exacerbated skin cancer statistics. Current treatment modalities such as surgery, radiotherapy, conventional chemotherapy, targeted therapy, and immunotherapy are facing several issues related to cost, toxicity, and bioavailability thereby leading to declined anti-skin cancer therapeutic efficacy and poor patient compliance. In the context of overcoming this limitation, several nanotechnological advancements have been witnessed so far. Among various nanomaterials, nanoparticles have endowed exorbitant advantages by acting as both therapeutic agents and drug carriers for the remarkable treatment of skin cancer. The small size and large surface area to volume ratio of nanoparticles escalate the skin tumor uptake through their leaky vasculature resulting in enhanced therapeutic efficacy. In this context, the present review provides up to date information about different types and pathology of skin cancer, followed by their current treatment modalities and associated drawbacks. Furthermore, it meticulously discusses the role of numerous inorganic, polymer, and lipid-based nanoparticles in skin cancer therapy with subsequent descriptions of their patents and clinical trials. Graphical Abstract

show abstract

Section: Microneedle Patch For Skin Cancer Therapymentioning

confidence: 99%

Section: Microneedle Patch For Skin Cancer Therapymentioning

confidence: 99%

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Compared with intravenous administration, the drug delivered by hollow MNs could achieve 10 h of sustainable release while maintaining the same dosage [ 42 ]. At the same time, hollow MNs have been proved to be able to completely deliver up to 2 mL of liquid and deposit 75% of the administered drug in the skin [ 39 , 41 ]. However, the preparation of hollow MNs requires a series of complex means, such as the use of vacuum pumping.…”

Section: The Different Types Of Mns In the Treatment Of Tumorsmentioning

confidence: 99%

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Wang

et al. 2023

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion. Most importantly, MNs can provide not only efficient and rarely painful delivery carriers, but also combine multi-model strategies with photothermal therapy (PTT), immunotherapy, and gene therapy for synergistic efficacy. To promote an in-depth understanding of their superiorities, this paper systematically summarized the latest application progress of MNs in the treatment of SST by delivering various types of photosensitizers, immune signal molecules, genes, and chemotherapy drugs. Just as important, the advantages, limitations, and drug release mechanisms of MNs based on different materials are introduced in the paper. In addition, the application of MN technology to clinical practice is the ultimate goal of all the work. The obstacles and possible difficulties in expanding the production of MNs and achieving clinical transformation are briefly discussed in this paper. To be anticipated, our work will provide new insights into the precise and rarely painful treatment of SST in the future. Graphical Abstract

show abstract

“…The development of new photosensitizers, porphylipoprotein and talaporphyrin sodium, metal complex base, aggregation-induced emission, and doped carbon dot-based photosensitizers have received considerable attention in cancer treatment [ 39 , 40 , 41 , 42 ]. The use of nanoparticle-based PDV has enhanced the rate of detection of nonmelanoma and melanoma skin cancers with promising therapeutic potential [ 43 , 44 ]. Photosensitizers are also employed as a therapeutic mechanism against skin cancers.…”

Section: Classical Diagnostic and Treatment Modalities For Skin Cancersmentioning

confidence: 99%

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Farhana

2023

IJMS

View full text Add to dashboard Cite

Skin cancers, especially melanomas, present a formidable diagnostic and therapeutic challenge to the scientific community. Currently, the incidence of melanomas shows a high increase worldwide. Traditional therapeutics are limited to stalling or reversing malignant proliferation, increased metastasis, or rapid recurrence. Nonetheless, the advent of immunotherapy has led to a paradigm shift in treating skin cancers. Many state-of-art immunotherapeutic techniques, namely, active vaccination, chimeric antigen receptors, adoptive T-cell transfer, and immune checkpoint blockers, have achieved a considerable increase in survival rates. Despite its promising outcomes, current immunotherapy is still limited in its efficacy. Newer modalities are now being explored, and significant progress is made by integrating cancer immunotherapy with modular nanotechnology platforms to enhance its therapeutic efficacy and diagnostics. Research on targeting skin cancers with nanomaterial-based techniques has been much more recent than other cancers. Current investigations using nanomaterial-mediated targeting of nonmelanoma and melanoma cancers are directed at augmenting drug delivery and immunomodulation of skin cancers to induce a robust anticancer response and minimize toxic effects. Many novel nanomaterial formulations are being discovered, and clinical trials are underway to explore their efficacy in targeting skin cancers through functionalization or drug encapsulation. The focus of this review rivets on theranostic nanomaterials that can modulate immune mechanisms toward protective, therapeutic, or diagnostic approaches for skin cancers. The recent breakthroughs in nanomaterial-based immunotherapeutic modulation of skin cancer types and diagnostic potentials in personalized immunotherapies are discussed.

show abstract

Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer

Cited by 53 publications

References 85 publications

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Contact Info

Product

Resources

About