Hollow mesoporous Ia3d silica nanospheres with singleunit-cell-thick shell: Spontaneous formation and drug delivery application

Lai, Nien-Chu; Lin, Cheng-Yao; Ku, Pei-Hsin; Chang, Lilin; Liao, Kai-Wei; Lin, Wun-Ting; Yang, Chia-Min

doi:10.1007/s12274-014-0503-2

Cited by 22 publications

(16 citation statements)

References 46 publications

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“…The XRD pattern of the HMC shows three signals that are indexed as (110), (211), and (220) reflections of structure Ia3d, shown as Figure 4 [30]. A transformation of structure occurred after the removal of the silica template.…”

Section: Resultsmentioning

confidence: 99%

Detection of Cigarette Smoke Using a Surface-Acoustic-Wave Gas Sensor with Non-Polymer-Based Oxidized Hollow Mesoporous Carbon Nanospheres

et al. 2019

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The objective of this research was to develop a surface-acoustic-wave (SAW) sensor of cigarette smoke to prevent tobacco hazards and to detect cigarette smoke in real time through the adsorption of an ambient tobacco marker. The SAW sensor was coated with oxidized hollow mesoporous carbon nanospheres (O-HMC) as a sensing material of a new type, which replaced a polymer. O-HMC were fabricated using nitric acid to form carboxyl groups on carbon frameworks. The modified conditions of O-HMC were analyzed with Scanning Electron Microscopy (SEM), Fourier transform infrared spectrometry (FTIR), and X-ray diffraction (XRD). The appropriately modified O-HMC are more sensitive than polyacrylic acid and hollow mesoporous carbon nanospheres (PAA-HMC), which is proven by normalization. This increases the sensitivity of a standard tobacco marker (3-ethenylpyridine, 3-EP) from 37.8 to 51.2 Hz/ppm and prevents the drawbacks of a polymer-based sensing material. On filtering particles above 1 μm and using tar to prevent tar adhesion, the SAW sensor detects cigarette smoke with sufficient sensitivity and satisfactory repeatability. Tests, showing satisfactory selectivity to the cigarette smoke marker (3-EP) with interfering gases CH4, CO, and CO2, show that CO and CO2 have a negligible role during the detection of cigarette smoke.

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Section: Resultsmentioning

confidence: 99%

Detection of Cigarette Smoke Using a Surface-Acoustic-Wave Gas Sensor with Non-Polymer-Based Oxidized Hollow Mesoporous Carbon Nanospheres

et al. 2019

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“…The synthesis systems using mixed cationic and nonionic surfactants are versatile in forming highly ordered mesoporous silicas with mesostructures in between 2D-hexagonal and lamellar phases and with unique morphologies. 3,4,29,30 The XRD patterns displayed that although the injection of TEOS alone with a rate of 3.0 ml h − 1 led to a 2D-rectangular MMT-1 material 3 (with unit cell parameters a and b of 10.9 nm and 4.5 nm, respectively), the partial replacement of TEOS by CPTES caused a transformation to a 2D-hexagonal structure ( Figure 1a). The structural transformation was almost complete when the fraction of CPTES in the silane mixture (f C ) reached 5%, and the XRD patterns of the samples synthesized with f C = 10 and 15% could be perfectly indexed with a p6 mm lattice.…”

Section: Resultsmentioning

confidence: 99%

Functional helical silica nanofibers with coaxial mixed mesostructures for the fabrication of PtCo nanowires that display unique geometry-dependent magnetism

et al. 2015

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Helical mesoporous silicas are notable from a self-assembly and applications points of view. We report a novel confinement-free synthesis of chloropropyl-functionalized helical mesoporous silica nanofibers (CP-HMSNFs) possessing straight channels at the fiber center surrounded by concentric short-pitch helical channels. The chloropropyl groups are found mainly distributed at the central cylindrical portion of the fibers, allowing the selective inclusion of guest species to fabricate novel nanocomposite fibers. Moreover, the chloropropyl-functionalized nanofibers were applied as a hard template to fabricate helical platinum-cobalt (PtCo) alloy nanowires with small and narrowly distributed radii of gyration. The helical metal nanowires exhibited distinct ferromagnetic properties as compared with their straight counterpart. NPG Asia Materials (2015) 7, e181; doi:10.1038/am.2015.39; published online 22 May 2015 INTRODUCTIONHelical mesoporous silicas 1-11 are analogous to the self-assembled helical biomaterials in nature and have attracted a substantial amount of attention. These helical silicas are also promising hard templates for the preparation of helical nanowires composed of metals [12][13][14][15] or other compositions that may possess unique optical, 16,17 electromagnetic 9,18 or other properties. Efforts to understand the formation mechanism of these helical nanostructures provide additional insights into the interplay of the thermodynamics and kinetics of the assembly of structure-directing surfactants and inorganic silicate species 1,2,19,20 and may also lead to the design and synthesis of additional novel selfassembled nanomaterials with controllable mesostructures and morphologies, allowing for innovative applications. 9,11,21 The first synthesis of helical mesoporous silica materials displaying a MCM-41-like two-dimensional (2D)-hexagonal structure was performed in a static two-phase acidic system. 7 Helical 2D-hexagonal mesoporous silica nanofibers (HMSNFs) or nanorods were then synthesized in single-phase dilute solutions using chiral 5 or achiral 2,20,22 surfactants. The helical formation is mainly driven by a reduction in the free energy of the surface, from straight micellar rods until the free energy is balanced by an increased bending energy. 2,20 Alternatively, HMSNFs can be prepared by evaporation-induced selfassembly (EISA) in porous anodic alumina membranes. 23,24 The confined EISA may result in helical and other thermodynamically more stable mesophases, the former generally being kinetically favored. Notably, materials with mixed mesostructures can also be

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“…MMT-2 was synthesized following the procedures reported previously [ 33 ]. In a typical synthesis, TEOS (5.98 mL) was injected to the solution that contained BCDAC (0.74 g), C16E2 (0.26 g), 0.4 M NaOH (21.4 mL), and water (575 mL) at a rate of 7.5 mL h − 1 at 35 o C. The mixture was stirred at 35 o C for 2 h and then was aged at 90 o C for 24 h. The solid product was filtered, washed with water and acetone, and finally dried at 60 o C.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, MMT-2, a novel type of thin-shell HMSNs with three-dimensionally interconnected mesopores we previously developed [ 33 ], was applied to integrate the therapeutic utilities of PpIX and TPZ and the targeting capability of the DNA aptamer LXL-1 for TNBC cell line MDA-MB-231. PpIX and LXL-1 were modified covalently on the mesopores and external surface of MMT-2, respectively, and TPZ was finally loaded largely into the hollow interior of the functionalized MMT-2, designated as LXL-1-PpIX-MMT-2, by impregnation (Scheme 1 ).…”

Section: Introductionmentioning

confidence: 99%

Targeting triple‐negative breast cancer with an aptamer‐functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies

et al. 2021

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Background Areas of hypoxia are often found in triple-negative breast cancer (TNBC), it is thus more difficult to treat than other types of breast cancer, and may require combination therapies. A new strategy that combined bioreductive therapy with photodynamic therapy (PDT) was developed herein to improve the efficacy of cancer treatment. Our design utilized the characteristics of protoporphyrin IX (PpIX) molecules that reacted and consumed O2 at the tumor site, which led to the production of cytotoxic reactive oxygen species (ROS). The low microenvironmental oxygen levels enabled activation of a bioreductive prodrug, tirapazamine (TPZ), to become a toxic radical. The TPZ radical not only eradicated hypoxic tumor cells, but it also promoted therapeutic efficacy of PDT. Results To achieve the co-delivery of PpIX and TPZ for advanced breast cancer therapy, thin-shell hollow mesoporous Ia3d silica nanoparticles, designated as MMT-2, was employed herein. This nanocarrier designed to target the human breast cancer cell MDA-MB-231 was functionalized with PpIX and DNA aptamer (LXL-1), and loaded with TPZ, resulting in the formation of TPZ@LXL-1-PpIX-MMT-2 nanoVector. A series of studies confirmed that our nanoVectors (TPZ@LXL-1-PpIX-MMT-2) facilitated in vitro and in vivo targeting, and significantly reduced tumor volume in a xenograft mouse model. Histological analysis also revealed that this nanoVector killed tumor cells in hypoxic regions efficiently. Conclusions Taken together, the synergism and efficacy of this new therapeutic design was confirmed. Therefore, we concluded that this new therapeutic strategy, which exploited a complementary combination of PpIX and TPZ, functioned well in both normoxia and hypoxia, and is a promising medical procedure for effective treatment of TNBC.

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Hollow mesoporous Ia3d silica nanospheres with singleunit-cell-thick shell: Spontaneous formation and drug delivery application

Cited by 22 publications

References 46 publications

Detection of Cigarette Smoke Using a Surface-Acoustic-Wave Gas Sensor with Non-Polymer-Based Oxidized Hollow Mesoporous Carbon Nanospheres

Detection of Cigarette Smoke Using a Surface-Acoustic-Wave Gas Sensor with Non-Polymer-Based Oxidized Hollow Mesoporous Carbon Nanospheres

Functional helical silica nanofibers with coaxial mixed mesostructures for the fabrication of PtCo nanowires that display unique geometry-dependent magnetism

Targeting triple‐negative breast cancer with an aptamer‐functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies

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