Hollow core photonic crystal fiber surface enhanced Raman probe

He, Yonghong; Gu, Changzhi; Yang, Changxi; Liu, Jie; Jin, Guofan; Zhang, Jiatao; Hou, Lantian; Yao, Yuan

doi:10.1117/12.698684

Cited by 27 publications

(25 citation statements)

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“…There has been significant interest in using SERS and fibers for chemical, biological, and environmental detections. The combination of both offers the advantages of the molecular specificity of Raman scattering, the big enhancement factor of SERS, and flexibility of fibers [179]. Rhodamine B detection through a four-hole SCF with gold nanoparticles serving as substrate was presented, with large interaction volume between the excitation light and the nanoparticles [180].…”

Section: Molecular Sensorsmentioning

confidence: 99%

Photonic Crystal Fibers for Sensing Applications

2012

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Photonic crystal fibers are a kind of fiber optics that present a diversity of new and improved features beyond what conventional optical fibers can offer. Due to their unique geometric structure, photonic crystal fibers present special properties and capabilities that lead to an outstanding potential for sensing applications. A review of photonic crystal fiber sensors is presented. Two different groups of sensors are detailed separately: physical and biochemical sensors, based on the sensor measured parameter. Several sensors have been reported until the date, and more are expected to be developed due to the remarkable characteristics such fibers can offer.

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Section: Molecular Sensorsmentioning

confidence: 99%

Photonic Crystal Fibers for Sensing Applications

2012

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“…These arrays were made using photonic crystal fibers, which acted as waveguides for light and yielded high Raman signal enhancement. They were also made in a reproducible fashion, formed from long, identical fibers [49]. To further induce reproducibility of the SERS measurement, several studies implemented a commercially available substrate, Klarite, from D3 Technologies Ltd., to detect chemical and biological agents [50][51][52][53][54].…”

Section: Surface-enhanced Raman Spectroscopy (Sers)mentioning

confidence: 99%

Raman Spectroscopy for Homeland Security Applications

Mogilevsky

Borland

Brickhouse

et al. 2012

International Journal of Spectroscopy

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Raman spectroscopy is an analytical technique with vast applications in the homeland security and defense arenas. The Raman effect is defined by the inelastic interaction of the incident laser with the analyte molecule's vibrational modes, which can be exploited to detect and identify chemicals in various environments and for the detection of hazards in the field, at checkpoints, or in a forensic laboratory with no contact with the substance. A major source of error that overwhelms the Raman signal is fluorescence caused by the background and the sample matrix. Novel methods are being developed to enhance the Raman signal's sensitivity and to reduce the effects of fluorescence by altering how the hazard material interacts with its environment and the incident laser. Basic Raman techniques applicable to homeland security applications include conventional (off-resonance) Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS), resonance Raman spectroscopy, and spatially or temporally offset Raman spectroscopy (SORS and TORS). Additional emerging Raman techniques, including remote Raman detection, Raman imaging, and Heterodyne imaging, are being developed to further enhance the Raman signal, mitigate fluorescence effects, and monitor hazards at a distance for use in homeland security and defense applications.

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“…While HC-PCF offers higher interaction length between the light and the analyte and lower sample consumption, SERS provides large enhancement factors to increase the sensitivity of normal Raman signal, thereby enabling detection of molecules in various applications. Thus, the integration of HC-PCF and SERS provides an ideal platform for detection of biomolecules [20,21].…”

Section: Introductionmentioning

confidence: 99%

Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS)

Khetani

Momenpour

Alarcon

et al. 2015

Biomed. Opt. Express

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The present paper demonstrates an antibody-free, robust, fast, and portable platform for detection of leukemia cells using Raman spectroscopy with a 785-nm laser diode coupled to a hollow core photonic crystal (HC-PCF) containing silver nanoparticles. Acute myeloid leukemia is one of the most common bone marrow cancers in children and youths. Clinical studies suggest that early diagnosis and remission evaluation of myoblasts in the bone marrow are pivotal for improving patient survival. However, the current protocols for leukemic cells detection involve the use of expensive antibodies and flow cytometers. Thus, we have developed a new technology for detection of leukemia cells up to 300 cells/ml using a compact fiber HC-PCF, which offers a novel alternative to existing clinical standards. Furthermore, we were also able to accurately distinguish live, apoptotic and necrotic leukemic cells.

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Hollow core photonic crystal fiber surface enhanced Raman probe

Cited by 27 publications

References 0 publications

Photonic Crystal Fibers for Sensing Applications

Photonic Crystal Fibers for Sensing Applications

Raman Spectroscopy for Homeland Security Applications

Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS)

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