Holistic Strategies to Control Salmonella Infantis: An Emerging Challenge in the European Broiler Sector

Montoro-Dasi, Laura; Lorenzo-Rebenaque, Laura; Marco-Fuertes, Ana; Vega, Santiago; Marín, Clara

doi:10.3390/microorganisms11071765

Cited by 15 publications

(16 citation statements)

References 125 publications

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“…Since 2014, S. Infantis has by far been the no. 1 serovar isolated in broiler production in many MSs (Montoro-Dasi et al, 2023); such phenomena could also occur with other serovars, which are progressively increasing in other poultry populations. For instance, over the last couple of years, S. Anatum and S. Agona were reported in turkeys and ranked in the top positions for the serovars identified, even though their notification from human cases is rather uncommon.…”

Section: Discussionmentioning

confidence: 99%

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The European Union One Health 2022 Zoonoses Report

2023

EFS2

107

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This report by the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of the zoonoses monitoring and surveillance activities carried out in 2022 in 27 Member States (MSs), the United Kingdom (Northern Ireland) and 11 non-MSs. Key statistics on zoonoses and zoonotic agents in humans, food, animals and feed are provided and interpreted historically. In 2022, the first and second most reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The number of cases of campylobacteriosis and salmonellosis remained stable in comparison with 2021. Nineteen MSs and the United Kingdom (Northern Ireland) achieved all the established targets in poultry populations for the reduction of Salmonella prevalence for the relevant serovars. Salmonella samples from carcases of various animal species, and samples for Campylobacter quantification from broiler carcases, were more frequently positive when performed by the competent authorities than when own checks were conducted. Yersiniosis was the third most reported zoonosis in humans, followed by Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes infections. L. monocytogenes and West Nile virus infections were the most severe zoonotic diseases, with the most hospitalisations and highest case fatality rates. In 2022, reporting showed an increase of more than 600% compared with 2021 in locally acquired cases of human West Nile virus infection, which is a mosquito-borne disease. In the EU, the number of reported foodborne outbreaks and cases, hospitalisations and deaths was higher in 2022 than in 2021. The number of deaths from outbreaks was the highest ever reported in the EU in the last 10 years, mainly caused by L. monocytogenes and to a lesser degree by Salmonella. Salmonella and in particular S. Enteritidis remained the most frequently reported causative agent for foodborne outbreaks. Norovirus (and other calicivirus) was the agent associated with the highest number of outbreak human cases. This report also provides updates on brucellosis, Coxiella burnetii (Q fever), echinococcosis, rabies, toxoplasmosis, trichinellosis, infection with Mycobacterium tuberculosis complex (focusing on Mycobacterium bovis and Mycobacterium caprae) and tularaemia.

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Section: Discussionmentioning

confidence: 99%

“…Infantis has by far been the no. 1 serovar isolated in broiler production in many MSs (Montoro‐Dasi et al., 2023 ); such phenomena could also occur with other serovars, which are progressively increasing in other poultry populations. For instance, over the last couple of years, S .…”

Section: Discussionmentioning

confidence: 99%

The European Union One Health 2022 Zoonoses Report

2023

EFS2

107

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“…However, bacterial contamination on broiler farms is increasingly related to the S . Infantis serotype [ 21 , 22 , 23 ]. Other relevant serotypes associated with chicken meat in Germany and Vietnam are S .…”

Section: Introductionmentioning

confidence: 99%

A Bacteriophage Cocktail Reduces Five Relevant Salmonella Serotypes at Low Multiplicities of Infection and Low Temperatures

Gvaladze,

Lehnherr,

Große-Kleimann

et al. 2023

Microorganisms

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Salmonella are important pathogenic bacteria and, following Campylobacter, they are the second most common cause of bacterial foodborne infections worldwide. To reduce the presence of bacteria along the food chain, the application of bacteriophages (phages) may be a promising tool. In this study, the lytic properties of six phages against five relevant Salmonella serotypes (S. Enteritidis, S. Typhimurium, S. Infantis, S. Paratyphi B and S. Indiana) were analyzed. Three phages were able to lyse all five serotypes. We determined the lytic potential of each phage on indicator strains in vitro at room temperature (RT) and at 37 °C using low multiplicities of infection (MOIs). Most phages reduced their host more efficiently at RT than at 37 °C, even at the lowest MOI of 0.001. Following this, the lytic activity of a cocktail comprising five phages (MOI = 0.1) was examined with each of the five serotypes and a mix of them at RT, 15, 12, 10, 8 and 6 °C. All cultures of single serotypes as well as the mixture of strains were significantly reduced at temperatures as low as 8 °C. For single serotypes, reductions of up to 5 log10 units and up to 2.3 log10 units were determined after 6 h (RT) and 40 h (8 °C), respectively. The mixture of strains was reduced by 1.7 log10 units at 8 °C. The data clearly suggest that these phages are suitable candidates for biocontrol of various Salmonella serotypes under food manufacturing conditions.

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“…Although different serotypes have been associated with salmonellosis, recent studies have reported Salmonella enterica subsp. enterica serovar Infantis as being widely spread through chicken meat [1,11] and Salmonella enterica subsp. enterica serovar Enteritidis through eggs [1,12].…”

Section: Introductionmentioning

confidence: 99%

Phage-Based Biosanitation Strategies for Minimizing Persistent Salmonella and Campylobacter Bacteria in Poultry

Jordá,

Lorenzo-Rebenaque,

Montoro-Dasi

et al. 2023

Animals

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Control strategies to minimize pathogenic bacteria in food animal production are one of the key components in ensuring safer food for consumers. The most significant challenges confronting the food industry, particularly in the major poultry and swine sectors, are antibiotic resistance and resistance to cleaning and disinfection in zoonotic bacteria. In this context, bacteriophages have emerged as a promising tool for zoonotic bacteria control in the food industry, from animals and farm facilities to the final product. Phages are viruses that infect bacteria, with several advantages as a biocontrol agent such as high specificity, self-replication, self-limitation, continuous adaptation, low inherent toxicity and easy isolation. Their development as a biocontrol agent is of particular interest, as it would allow the application of a promising and even necessary “green” technology to combat pathogenic bacteria in the environment. However, bacteriophage applications have limitations, including selecting appropriate phages, legal restrictions, purification, dosage determination and bacterial resistance. Overcoming these limitations is crucial to enhance phage therapy’s effectiveness against zoonotic bacteria in poultry. Thus, this review aims to provide a comprehensive view of the phage-biosanitation strategies for minimizing persistent Salmonella and Campylobacter bacteria in poultry.

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Holistic Strategies to Control Salmonella Infantis: An Emerging Challenge in the European Broiler Sector

Cited by 15 publications

References 125 publications

The European Union One Health 2022 Zoonoses Report

The European Union One Health 2022 Zoonoses Report

A Bacteriophage Cocktail Reduces Five Relevant Salmonella Serotypes at Low Multiplicities of Infection and Low Temperatures

Phage-Based Biosanitation Strategies for Minimizing Persistent Salmonella and Campylobacter Bacteria in Poultry

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