Holes in gastric mucosa in upper gastrointestinal endoscopy

Effenberger, Maria; Steinle, Hartmut; Offner, Felix; Vogel, Wolfgang; Millonig, Gunda

doi:10.1097/meg.0000000000000050

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Gastritis cystica profunda is a rare pathological lesion of the stomach characterized by elongation and hyperplasia of the gastric foveolae, disruption of the muscolaris mucosae and deep epithelial migration and proliferation, with many cystically dilatated glands in the submucosa. In the literature, several terms have been proposed to describe this entity, such as gastritis cystica polyposa, multiple polypoid cystic gastritis, heterotopic cystic malformation of the stomach and diffuse submucosal cysts of the stomach [2,3,7]. GCP is more commonly found in the fundus of the stomach, but it can occur in other gastric regions as well.…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis of submucosal gastric lesions should include leiomyoma, lipoma, gastrointestinal stromal tumor, lymphoma, leiomyosarcoma, neuroendocrine cell tumors, schwannomas, Menetrier's disease and GCP [7,21,28,32]. Moreover, when facing a submucosal lesion and suspecting GCP, it is paramount to differentiate GCP from adenocarcinoma of the stomach.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation of GCP is vague, and in most cases, it is an incidental finding [7]. More commonly occurring symptoms are gastrointestinal bleeding, abdominal pain, weight loss, anorexia and gastric outlet obstruction [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature

De Stefano,

Graziano,

Viganò

et al. 2023

Medicina

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Gastritis cystica profunda (GCP) has been defined as a rare submucosal benign gastric lesion with cystic gland growth. Due to its unclear etiopathogenesis, this lesion is often misdiagnosed and mistaken for other gastric masses. Currently, a standardized treatment for GCP lesions is still missing. Here, we illustrate a case of a patient admitted to our general surgery department for melena and general discomfort. No history of peptic ulcer or gastric surgery was present. Upper GI endoscopy was performed, showing a distal gastric lesion with a small ulceration on the top. CT-scan and endoscopic ultrasound confirmed the presence of the lesion, compatible with a gastric stromal tumor, without showing any eventual metastasis. Surgical gastric resection was performed. Histological findings were diagnostic for GCP, with cistically ectasic submucosal glands, chronic inflammation, eosinophilic infiltration and foveal hyperplasia. GCP is a very exceptional cause of upper-GI bleeding with specific histological features. Its diagnosis as well as its therapy are challenging, resulting in several pitfalls. Even though it is a rare entity, GCP should always be considered in the differential diagnosis of gastric submucosal lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature

De Stefano,

Graziano,

Viganò

et al. 2023

Medicina

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Non-syndromic Epithelial Polyps of the Gastrointestinal Tract

Gui

Wang

Olson

2020

Practical Gastrointestinal Pathology

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Gastritis cystica profunda: a case report and literature review

Du¹,

Zhang²,

Ma³

et al. 2020

Ann Palliat Med

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Gastric cystica profunda (GCP) is a rare disease characterized by multiple cystic lesions in the mucosa and/or submucosal layer. Usually, GCP occurs in stomachs that have previously been operated on.If there is no postoperative pathological results, it is challenging to diagnose GCP based on nonspecific clinical symptoms and imaging findings. This report aimed to provide a comprehensive overview of all cases of GCP reported to date. A comprehensive literature search was conducted for all reported GCP cases between 1972 and 2014. The keywords searched included "gastritis cystica profunda", "submucosal cysts of the stomach", and "heterotopic submucosal gastric glands". One retrospective case from our group was also reported and compared with those from the existing literature. A total of 52 cases were found including 37 (71.2%) men and 15 (28.8%) women (M/F ratio =2.5). The mean age of the patients was 59.9 (range, 39-91) years old. Among the cases, 58.8% (n=30) of lesions were located in the gastric body, 25.5% (n=13) of lesions were located in the fundus, 19.6% (n=9) of lesions were located in the antrum, and 3.9% (n=2) of lesions were located in the cardia, while 1 case was in the prepyloric lesion and 1 case was at the anastomotic site. Of the patients, 52% (n=26) had previously received gastric surgery. The main manifestations of GCP included abdominal pain (n=14, 36.8%) and gastrointestinal bleeding (including hematemesis and melena, n=7, 18.4%). Only 4 of the 52 cases were diagnosed before surgery, and the rest were diagnosed through postoperative histopathologic examination. GCP is difficult to correctly diagnose preoperatively due to its relative rarity and lack of typical clinical symptoms. Histopathological examination should be used for correct diagnosis. Complete surgical removal of the GCP is widely considered as the best treatment option.

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Holes in gastric mucosa in upper gastrointestinal endoscopy

Cited by 3 publications

References 17 publications

Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature

Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature

Non-syndromic Epithelial Polyps of the Gastrointestinal Tract

Gastritis cystica profunda: a case report and literature review

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