Holding Power of Bioabsorbable Ciprofloxacin-Containing Self-reinforced Poly-L/DL-lactide 70/30 Bioactive Glass 13 Miniscrews in Human Cadaver Bone

Abstract

Antibiotics-plus bioactive glass-containing bioabsorbable self-reinforced (SR) polylactide screws have been developed for antibacterial osteoconductive bone fixation. The aim of the present study was to test the pullout properties of these recently developed miniscrews. Ciprofloxacin-plus bioactive glass-containing SR-polylactide miniscrews (BC) were compared with miniscrews made of neat SR-polylactide (A), SR-polylactide with bioactive glass (B), and ciprofloxacin-containing SR-polylactide (C). BC miniscrews and their controls (A, B, C) (all of length 6.0 mm, core diameter 1.45 mm, thread diameter 2.0 mm) were applied to one pair of cadaveric fibulae. Pullout force was measured using a materials testing machine. We carried out 49-50 pullout tests for each implant type. The Mann-Whitney test and Student's t-test were used for statistical evaluation. The pullout force for BC miniscrews was 114.9 +/- 34.0 (SD) N. Pullout forces for control miniscrews were 162.7 +/- 37.8 N (A), 99.1 +/- 16.2 N (B), and 142.9 +/- 26.9 N (C). Differences between the four groups were statistically significant (p < 0.001). Ciprofloxacin-plus bioactive glass-containing polylactide miniscrews have good holding power to human cadaver fibulae. However, adding bioactive glass and ciprofloxacin components to neat SR-polylactide results in lower pullout values.

Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing

“…The silk pins reached a maximum shear stress of 80.2 ± 8.5 MPa, which is comparable to that of the HFIP solvent-based systems (~ 90 MPa) [28]. These values are also comparable with the current resorbable systems which have a shear force of 100–185 MPa [46, 47]. The mechanical properties of silk plates were measured by a four-point bending test using four-hole plates of 29 mm length and 2 mm thickness (Figure 2h).…”

Use of Bioabsorbable Osteofixation Devices in the Hand

“…The clinical, radiological and histological results were similar at follow-up times of 1 to 6 weeks, whereas conservative treatment yielded less successful results. SR-P(L/DL)LA 70/30 miniscrews containing antibiotics and bioactive glass have been developed for antibacterial osteoconductive bone fixation and have been found to have good holding power (Leinonen et al, 2002).…”

Bioabsorbable fixation devices in trauma and bone surgery: current clinical standing

“…In addition, multifunctional screws and plates will be developed, which are in part based on the use of bioabsorbable implants as a source of conventional pharmacologic and new biologic drugs. Antibiotic-releasing screws have already been developed to prevent and treat bone infections [2, [106][107][108]. Other types of multifunctional biomaterials contain agents such as growth factors to confer osteoinductivity to these implants.…”