Hoffmann syndrome : about two new cases

Saïd, F.; Tliba, A; Khanfir, M.; Lamloum, M.; Houman, M.H.

doi:10.30637/2018.17-087

Cited by 3 publications

(3 citation statements)

References 7 publications

(14 reference statements)

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“…In the patient studied, marked asthenia was important clinical elements, which is practically considered a requirement in the diagnosis of decompensated hypothyroidism to the point that more than 90% of hypothyroid people present the clinical characteristics of asthenia due to thyroid hypofunction. [12][13][14] Other elements were muscle pain, mostly affecting large proximal groups, achillean osteotendinous areflexia, thyroid enlargement and involuntary muscle contractions in a young patient with an apparent history of health and stigmas of endocrine dysfunction due to anemia, disorders menstrual and galactorrhea. [14,15] The high increased muscle enzymes, in a patient with suspected muscle disease and goiter, oriented the diagnosis towards a thyroid disease, which was confirmed with alterations in TSH, T4 and T3.…”

Section: Discussionmentioning

confidence: 99%

Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report

Cabrera¹,

Pérez²,

Sánchez³

et al. 2021

AJLM

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Hoffmann syndrome is defined since 1897 as the combination of hypothyroidism with myopathy, mioedema, rigidity, muscle cramps, and hypertrophy. The objective of this publication is to describe a typical case of thyroid disease with clinical, hormonal, and muscular characteristics of a Hoffmann syndrome, as an exceptional manifestation of hypothyroidism. The clinical challenge consisted in linking the apparent ambiguity of the clinical symptoms such as: generalized weakness, fatigue, muscle cramps in a young patient, without personal record of previous disease, apparently healthy and well-nourished with favorable muscle development. Additionally, manifestation of pituitary gland dysfunction was found, such as headache and galactorrhea, bibliography reviewed showed mainly, male patients patter and not any comment concerning hypophysis impairment. all clinical manifestations disappeared after replacement treatment with levothyroxine, including the goiter and pituitary macroadenoma. The management of the case involved a multidisciplinary team and involved internists, cardiologist, endocrinologists, radiologist, and neurosurgeons. This form of thyroid myopathy is rare and usually accompanies adult patients with severe and long-standing hypothyroidism, is different from those that begin in early childhood and are associated with cretinism and muscle hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report

Cabrera¹,

Pérez²,

Sánchez³

et al. 2021

AJLM

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“…Thyroid hormone levels are controlled by the hypothalamus–pituitary–thyroid axis, but the threshold for activation differs depending on nutritional status, illness, and aging of the individual. The consequences of which contribute to various changes in the body through biochemical actions, namely, hormonal factors, leading to a decreasing muscle mass, which is sarcopenia 6 …”

Section: Introductionmentioning

confidence: 99%

“…T3 is known to have 4 times more physiological role than fT4 and has a half‐life of 1.0 to 1.4 days as compared with 6.2 to 7.5 days for fT4. T3 is known to decrease with age and has a biophysical role in muscle metabolism and regeneration through its action in the mitochondria, 6,9 making it an adequate study focus.…”

Section: Introductionmentioning

confidence: 99%

Analysis of thyroid hormones and sarcopenia: association of creatine kinase and thyroid hormones (thyroid‐stimulating hormone, triiodothyronine, and free thyroxine): a cross‐sectional study

Hong

Linton

Kim

et al. 2021

JCSM Clinical Reports

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BackgroundKorea is an ‘aged’ society on its way to becoming a ‘super aged’ society. As the population ages, new medical diseases become more prevalent. One such problem is sarcopenia. Sarcopenia, by definition, is skeletal muscle loss. Furthermore, additional studies have also pointed out smooth muscle loss. In this study, we focused on the correlation between thyroid hormones and sarcopenia with a biochemical viewpoint through creatine kinase.MethodsThis study was undertaken using the Shinchon Severance Hospital clinical data repository system. Data were collected from 1 November 2005 to 17 May 2019. These data were from both male and female patients aged 20 years or more, who visited the emergency department, outpatient clinic, or were admitted. Our review consisted of laboratory data, image data, and the physical status of the patients described in words.ResultsHigher levels of creatine kinase were observed in groups with low triiodothyronine (T3), low free thyroxine (fT4), high thyroid‐stimulating hormone (TSH), and presence of dyslipidaemia. Correlation between creatine kinase and T3, fT4, and TSH was consistent after dyslipidaemia confounding factor was removed or adjusted for.ConclusionThere was a consistent negative correlation between creatine kinase and fT4 and T3, both within the normal and abnormal range of thyroid hormone levels. Thyroid hormone replacement therapy with synthetic fT4 has its limitations. More studies are warranted for use of T3 or T3 receptor agonists.

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Hoffmann’s syndrome in the differential work-up of myopathic complaints: a case report

Winter,

Heiling,

Eckardt

et al. 2023

J Med Case Reports

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Background Hoffmann’s syndrome is a rare form of hypothyroid myopathy in adults, which is mainly characterized by muscular weakness and muscular pseudohypertrophy. Case presentation We report about a 61-year-old Western European man with myalgia, myxedema and pseudohypertrophy of the calf muscles. Laboratory tests revealed significantly elevated thyroid stimulating hormone (TSH) and creatine kinase (CK). Muscle MRI showed muscular hypertrophy of the lower limbs, but no signs of myositis or myopathy (no gadolinium enhancement, no edema, no fatty degeneration). In addition, electromyography (EMG) detected spontaneous activity. After the beginning of thyroxin-therapy it took six months until the muscle weakness improved and the myalgia regressed. Conclusions Here, we focus on diagnostic routines and typical findings to differentiate Hoffmann’s syndrome from other myopathies. Clinical hallmarks of Hoffmann’s syndrome are pseudohypertrophy and weakness of the calf muscles in combination with elevated CK and elevated TSH. EMG is well suited to detect the involvement of the muscles and muscle MRI helps to differentiate it from other myopathies. Hoffmann’s syndrome is a rare myopathy due to hypothyroidism and plays a role in the differential diagnosis of myopathic complaints even if hypothyroidism has not been detected before.

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Hoffmann syndrome : about two new cases

Abstract: Hypothyroidism is exceptionnally revealed by hypertrophic myopathy, known as Hoffmann syndrome. We report two new cases of severe hypothyroidism presenting as hypertrophic myopathy, occurring in two men of 49 and 57 years-old.

Cited by 3 publications

References 7 publications

Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report

Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report

Analysis of thyroid hormones and sarcopenia: association of creatine kinase and thyroid hormones (thyroid‐stimulating hormone, triiodothyronine, and free thyroxine): a cross‐sectional study

Hoffmann’s syndrome in the differential work-up of myopathic complaints: a case report

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