Hodgkin’s lymphoma transformation of CLL/ SLL: case report and review of the literature

Gün, Seda; Atay, Memiş Hilmi; Turğut, Mehmet; Yıldız, Levent

doi:10.15761/cdp.1000116

Cited by 3 publications

(2 citation statements)

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“…Although DLBCL is the most common histology seen in patients with RT (2-8% cases), T cell lymphomas, multiple myeloma, Burkitt’s lymphoma and lymphoblastic lymphoma have also been reported. Hodgkin variant RT has been reported in <1% RT cases with only about 100 cases documented in literature till date 1 – 4 . It has been reported in older (age range 49-81 years) male patients (male: female ratio of 3.5:1).…”

Section: Discussionmentioning

confidence: 99%

Hodgkin Variant of Richter’s Transformation in Chronic Lymphocytic leukemia (CLL): An Illustrative Case Report and Literature Review

Gupta¹,

Mittal²,

Duggal³

et al. 2021

IJHOSCR

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Hodgkin lymphoma variant of Richter’s transformation (HL-RT) is a rare event, occurring in < 1% chronic lymphocytic leukemia (CLL) cases, of which, in < 10% cases, HL is the first finding leading to a diagnosis of CLL that co-exists simultaneously. Here we report a 60 years old male patient who presented with an outside diagnosis of lymphocyte-rich classical HL. On evaluation, he had only B-symptoms in the form of low-grade fever and weight loss. Peripheral smear revealed mild leukocytosis with an absolute lymphocytosis and a few smudge cells. Bone marrow (BM) aspirate and biopsy exhibited diffuse infiltration by a small cell, low grade, Non-Hodgkin’s lymphoma with no immunohistochemical evidence of HL. Flow cytometry performed on BM was consistent with classical immunoprofile of CLL. Meanwhile the lymph node received for review revealed diffuse effacement of nodal architecture by small mature lymphocytes with immunoprofile of CLL expressing CD20, CD5, and CD23. Interspersed between these cells, were a few eosinophils along with classical Reed Sternberg cells, expressing CD30, MUM-1, CD15, and dim PAX-5, with a surrounding rosette of T-Cells highlighted by CD3 and PD-1 and negative for CD45, CD20, and EBV immunohistochemistry. Fluorodeoxyglucose positron emission tomography (FDG-PET) scan revealed hepatosplenomegaly with multiple supra/infra diaphragmatic lymph nodes. So, a final diagnosis of HL-RT in CLL was considered. The patient is currently doing well after the first cycle of ABVD chemotherapy. HL-RT occurring in CLL is a rare event with heterogeneous clinical presentation, morphology, clonal origin, disease course, prognostic features, and survival.

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Section: Discussionmentioning

confidence: 99%

Hodgkin Variant of Richter’s Transformation in Chronic Lymphocytic leukemia (CLL): An Illustrative Case Report and Literature Review

Gupta¹,

Mittal²,

Duggal³

et al. 2021

IJHOSCR

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“…Besides, the transformation of Chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) into other types of aggressive lymphoma is reported during the disease, often accompanied by deteriorating illness and enlarged lymph nodes detected on physical exams or imaging (9)(10)(11)(12). In reviewing the literature, only a few cases (< 1%) of acute leukemic transformation have been reported (13,14).…”

Section: Introductionmentioning

confidence: 99%

Transformation of chronic lymphocytic leukemia into acute mixed phenotype leukemia myeloid/T neoplasm: a rare case report

Babaheidarian

Sadeghipour

Ansarinejad

et al. 2022

Preprint

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Introduction: Chronic lymphocytic leukemia (CLL) is defined by the presence of lymphocyte in the blood, bone marrow, lymph nodes, and spleen, with a median lymphocyte count of 20–30×109/L for more than three months. CLL is known to be rarely associated with myeloid malignancies. This study presents an extremely rare case of CLL, which transformed into myeloid /T neoplasm.Case presentation: A 62-year-old man with a 10-year history of CLL was referred to our hospital because of multiple skin bruises and anemia. He was monitored for ten years without any treatment until this time when the disease progressed, and chemotherapy was started. After eight months of treatment completion, he deteriorated. This time, bone marrow biopsy immunophenotyping revealed the transformation of CLL into mixed phenotype acute leukemia, myeloid/T neoplasm with no residue of preexisting CLL.Conclusion: Transformation of CLL into acute leukemia may arise from the same clone. Still, there is some evidence that it may be therapy-related, so any deterioration in a patient with CLL should be evaluated promptly for a better outcome.

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Transformation of Chronic Lymphocytic Leukemia into Acute Mixed Phenotype Leukemia Myeloid/T Neoplasm: a Case Report

Babaheidarian,

Sadeghipour,

Ansarinejad

et al. 2023

SN Compr. Clin. Med.

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Hodgkin’s lymphoma transformation of CLL/ SLL: case report and review of the literature

Cited by 3 publications

References 1 publication

Hodgkin Variant of Richter’s Transformation in Chronic Lymphocytic leukemia (CLL): An Illustrative Case Report and Literature Review

Hodgkin Variant of Richter’s Transformation in Chronic Lymphocytic leukemia (CLL): An Illustrative Case Report and Literature Review

Transformation of chronic lymphocytic leukemia into acute mixed phenotype leukemia myeloid/T neoplasm: a rare case report

Transformation of Chronic Lymphocytic Leukemia into Acute Mixed Phenotype Leukemia Myeloid/T Neoplasm: a Case Report

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