Hodgkin's disease of the thymus gland

Abstract

Forty‐four patients with Hodgkin's disease that was initially limited to the anterior mediastinum were studied by clinicopathologic analysis. In about half the cases there was involvement of the thymus gland, and in the other half there was involvement only of the anterior mediastinal lymph nodes. Evidence is presented that the thymic lesion, often called “granulomatous thymoma”4 is in fact Hodgkin's disease of the thymus gland. All but 4 patients had the nodular‐sclerosis type of Hodgkin's disease, and in all the cases in which the thymus gland was involved, nodular sclerosis was found. The patients with thymic involvement were younger, with a male predominance. The 5‐year survival rate of 79% was similar whether or not the thymus gland was involved, and was comparable to reported cases of Stage I Hodgkin's disease elsewhere in the body. More than half the patients with followup observation have had recurrences, most of them above the diaphragm. Cancer 33:1615–1623, 1974.

Thymic Carcinoma Associated With Multilocular Thymic Cyst

“…These include primary mediastinal tumors such as thymomas, germ cell tumors, and lymphomas. 1,[4][5][6]9,[11][12][13]15,18 In rare instances, metastatic Thymic Carcinoma Associated With MTC malignancy can be associated with MTC. 10 In addition, Suster et al 17 also described cases of MTC displaying an exuberant atypical epithelial proliferation of the lining epithelium reminiscent of the pseudoepitheliomatous hyperplasia in the skin or mucosal surfaces mimicking a malignant process.…”

Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology

“…60 The identification of a population of scattered large B cells in T-cell-rich interfollicular zones raises the question of whether they give rise to any category of human lymphoma. A potential candidate is classical Hodgkin disease, a B-cell neoplasm 24,61 that tends preferentially to involve interfollicular T-cell areas in lymph nodes [62][63][64][65] and also the thymus, 63,66 where the morphologically similar asteroid B cells are 4 only a fraction of monocytoid B cells (26%) carry mutated IgH rearrangements, whereas the majority (74%) are unmutated. Other studies have identified only mutated immunoglobulin genes.…”

The diversity of diffuse large B-cell lymphoma in extranodal sites: overview and update

“…Mediastinal large B-cell lymphoma and classical Hodgkin's lymphoma both tend to affect younger adults, with some female preponderance, and to produce mediastinal neoplasms that are characterized by a prominent sclerosis. Hodgkin's lymphoma usually arises in lymph nodes but in the mediastinum, may arise in the thymus [69]. Mediastinal large B-cell lymphoma is composed of large atypical cells, some of which may resemble Reed-Sternberg cells, that usually lack immunoglobulin and that may express CD30.…”