Hodgkin's disease involving the urinary bladder diagnosed by urinary cytology. A case report

Abstract

A unique case of lymphocyte depletion Hodgkin's disease of the urinary bladder in a 91‐year‐old woman was diagnosed by exfoliative cytology on a single passed urine specimen. Subsequent bladder biopsy confirmed the diagnosis. Retrospectively, it was ascertained that the patient had had a previous diagnosis of Hodgkin's disease based on biopsy of a cervical lymph node ten years previously. This is the first case to be reported in which the presence of Reed Sternberg cells in a cytologic preparation of the urine led to the diagnosis of Hodgkin's disease with involvement of the bladder.

Microfilaria in urine cytology: Report of three cases with review of literature

“…Vassenwala et al have reported two cases of urinary bladder carcinoma with associated microfilaria in urine sediment 13 . Although other primary tumors of bladder, namely small cell carcinoma, melanoma and Hodgkin lymphoma have been diagnosed on urine cytology, coexistent filarial infestation has not been reported in any of them 23‐25 . Few metastatic tumors like signet ring cell carcinoma of stomach, small cell carcinoma of ovary, lobular carcinoma of breast and metastatic melanoma have also been described in urine sediment 26‐29 .…”

“…13 Although other primary tumors of bladder, namely small cell carcinoma, melanoma and Hodgkin lymphoma have been diagnosed on urine cytology, coexistent filarial infestation has not been reported in any of them. [23][24][25] Few metastatic tumors like signet ring cell carcinoma of stomach, small cell carcinoma of ovary, lobular carcinoma of breast and metastatic melanoma have also been described in urine sediment. [26][27][28][29] However, presence of filarial worm with a concomitant metastatic carcinoma in urine cytology is extremely rare with a single case report of metastatic melanoma of bladder.…”

Hodgkin's Disease Involving the Urinary Bladder: A Case Report

“…In an autopsy series [10], HD involved the bladder in 4% of the cases that occurred in association with disseminated disease, causing urinary symptoms in only 13% of patients. A case report described urinary bladder relapse of HD ten years after mantle radiation therapy, given in a patient with CS I supradiaphragmatic disease [11]. In this latter report, the diagnosis was established initially in a urine specimen using exfoliative cytology.…”

“…In five large combined series, the most common presentation of subdiaphragmatic HD was peripheral inguinal, femoral, or superficial iliac lymphadenopathy, constituting approximately 80% of all cases [5]. While primary urinary bladder HD or nonHodgkin's lymphoma has been described previously [7][8][9], secondary involvement, particularly with HD, has been reported rarely [10,11]. In an autopsy series [10], HD involved the bladder in 4% of the cases that occurred in association with disseminated disease, causing urinary symptoms in only 13% of patients.…”

Lymphoma at uncommon sites

“…Urinary cytology may be helpful in diagnosis. 302 Primary disease of the bladder is extremely rare, though two cases have been reported. 303,304 Prostate Hodgkin's disease can affect the prostate gland, but yet again very rarely, and usually by local extension.…”