Hodgkin's disease and common variable immunodeficiency.

Guillain-Barre-Strohl Syndrome Unraveled as Paraneoplastic Syndrome of B-cell Acute Lymphoblastic Leukemia in a Patient with Preceding Common Variable Immunodeficiency Syndrome with Evans Syndrome

“…Spleen enlargement was also present in our patient, another typical symptom of CVID. Malignant lymphoproliferative diseases are reported as complications of CVID, namely different histological entities of Non-Hodgkin lymphoma (for overview see [12]), lymphoma of the CNS [13], gastrointestinal tract [14], lung [15], T cell lymphoma [16], and also Hodgkin's disease [17,18] develops in some patients. The BCL6 overexpression in the immunohistology is of note since CVID related lymphomas are reported to be associated with mutations and rearrangements of BCL6 [19].…”

Lymphoma complicating common variable immunodeficiency with granulomatous disease: report of two cases

“…Molecular and cytogenetic studies of lymphoproliferative lesions in CVID are generally lacking. A limited number of CVID patients with Hodgkin's or Hodgkin's disease‐like lymphomas have been reported to have visceral rather than nodal disease (3, 14, 15). Hodgkin's disease‐like B‐cell lymphoproliferative disorders have been identified in six immunodeficient patients but were, unlike patient 1, always EBV‐associated lymphomas (16).…”