Hodgkin’s Disease and Chronic Lymphatic Leukemia

Lokich, Jacob J.; Moloney, W. C.

doi:10.1159/000224700

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…In all the elderly patients Hodgkin's disease was the second malignancy diagnosed, and Hodgkin's disease was the cause of death in 3 of the 4 who were deceased. In addition to the solid tumors, three patients in the elderly group had chronic lymphatic leukemia [11], and one patient had polycythe mia vera, an association which has been previously observed [4],…”

Section: Cause O F Death and Associated Disorderssupporting

confidence: 59%

Hodgkin’s Disease in the Elderly

Lokich¹,

Pinkus²,

Moloney³

1974

Oncology

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47 patients with Hodgkin’s disease presenting after age 60 were analyzed retrospectively for clinical presentation, distribution of disease, and histopathology, and compared to a younger control group. The types of clinical presentation included: local or generalized adenopathy, 50%; ‘B’ symptoms, 25%; ‘unusual manifestations’ and intra-abdominal complications, 13%; and incidentally discovered disease, 12%. In contrast, the younger group presented less often for symptoms (p < 0.01) and more often for adenopathy (p < 0.01). Disease distribution was unique in the elderly compared to the young with a higher incidence of inguinal (p < 0.01), splenic (p < 0.01), and gastrointestinal disease (p < 0.01) and a lower indicence of mediastinal disease (p < 0.01). Histopathology in elderly patients revealed more lymphocyte depletion and less nodular sclerosis than the young patients. 38 of 47 elderly patients were classified as stage III or IV compared to 22/47 in the young. 26 elderly and only 9 young patients had ‘B’ symptoms. Survival was compared for pathologically matched stage IV A and B patients, and the median duration was 5 and 40 months for the elderly and young groups, respectively, (p < 0.001). This difference may be a consequence of differences in therapeutic approaches toward the elderly. Hodgkin’s disease has distinctive clinical and pathologic features which characterize the disease in the elderly and are relevant to diagnostic and therapeutic management.

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Section: Cause O F Death and Associated Disorderssupporting

confidence: 59%

Hodgkin’s Disease in the Elderly

Lokich¹,

Pinkus²,

Moloney³

1974

Oncology

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“…11 other malignancies occurred, among them 2 cases of chronic lymphatic leukaemia. This has previously been described in patients suffering from HD (Lokich & Moloney 1972). 6 cases of non-Hodgkin lymphoma developing during the observation period after treatment for HD have recently been described (Krikorian et a1 1979).…”

Section: Discussionmentioning

confidence: 75%

Hodgkin's Disease in Denmark: A National Clinical Study by the Danish Hodgkin Study Group, LYGRA

Nordentoft¹,

Pedersen‐Bjergaard²,

Brincker³

et al. 1980

Scandinavian Journal of Haematology

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ODENSE: ARHUS:ALBORG:During the last 8 years (1971-1979) all newly diagnosed previously untreated patients with Hodgkin's disease in Denmark have been centralized to uniform staging procedures and treatment. A total of 802 patients were registered, or 2 patients/ 100000. Lymphangiography was performed in 708 patients (88 %), and 437 patients (55 %) underwent laparotomy with splenectomy. Treatment included radiotherapy, combination chemotherapy (MOPP or similar programmes), and combined modality treatment. The overall 8-year actuarial survival for all stages combined was 66 %, and relapse-free survival was 55 %. 144 patients died of Hodgkin's disease, 23 from complications to therapy and examination procedures, and 54 died of unrelated causes. Survival was significantly better for patients without B-symptoms, and decreased gradually with advancing age. There was a strong correlation between unfavourable prognosis and advancing stage and/or histology, but mediastinal involvement had no influence upon the prognosis. Staging laparotomy was associated with 4 deaths due to infection, and splenectomy with 10 cases of severe pneumwmcal infections, 4 of which were fatal. Fatal complications due to subsequent treatment included 2 cases of cardiac arrest following mantle-field irradiation and 3 cases of haemorrhage or sepsis following Chemotherapy. 5 cases of acute myeloid leukaemia were observed.

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“…1,4,10,30 An interesting and more etiologically challenging transformation is HD terminally complicating CLL. Although several reports of this were published in the 1940-1970's, 7,13,[17][18][19]27,29,31 some authors refuted the diagnosis as misinterpretation of diffuse histiocytic lymphoma with "Reed-Sternberg-like" cells. 11,20 In recent years, with modern diagnostic tools of immunohistochemistry, flow cytometry and molecular genetics, several further reports of this phenomenon have been confirmed.…”

Section: Resultsmentioning

confidence: 99%