Hodgkin's and Castleman's disease in a patient with systemic mastocytosis

Saletti, Piercarlo; Ghielmini, Michele; Scali, G; Pedrinis, E; Gueneau, Melanie; Cavalli, F.

doi:10.1007/s002770050482

Cited by 26 publications

(13 citation statements)

References 18 publications

(17 reference statements)

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“…In contrast, the occurrence of a lymphoproliferative disorder in SM is rare, the most frequent "lymphoid" AHNMD being plasma cell myeloma [22][23][24][25][26][27]. In the current study, we present a patient with SM-AHNMD, in whom the AHNMD component of the disease was diagnosed as a CD23-negative atypical CLL (SLL/CLL) [30][31][32].…”

Section: Discussionmentioning

confidence: 63%

“…In several cases, the AHNMD component of the disease was classified as multiple myeloma [22][23][24]. However, there are only a few reports on Hodgkin lymphoma or non-Hodgkin lymphomas diagnosed as AHNMD in SM [25][26][27][28][29]. We report here on a unique case of SM with an associated non-Hodgkin lymphoma that was classified as small lymphocytic lymphoma (SLL)/chronic lymphatic leukemia (CLL) by available criteria [30][31][32].…”

Section: Introductionmentioning

confidence: 92%

“…In most of these patients, a myeloid neoplasm is diagnosed [15][16][17][18][19][20][21]. By contrast, only a few cases of associated lymphoproliferative disorders have been described [22][23][24][25][26][27][28]. In several cases, the AHNMD component of the disease was classified as multiple myeloma [22][23][24].…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease

et al. 2008

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease

et al. 2008

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“…12 In contrast, the association of SM with malignant lymphoproliferative disorders is a rare finding. [13][14][15][16][17] SM with an associated CLL has been previously described only once, in a 36 year old man who developed CLL 10 years after diagnosis of SM had been established on the basis of multifocal MC infiltrates in the bone marrow. 18 The present case of SM-CLL is unique in several clinical, morphological, and molecular aspects.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL)

Sotlar²,

Stellmacher³

et al. 2006

J Clin Pathol

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Aims: Whereas focal accumulations of reactive lymphocytes around mast cell (MC) infiltrates are often seen in indolent systemic mastocytosis (ISM) involving the bone marrow, an association of systemic mastocytosis (SM) with malignant lymphoma/lymphatic leukaemia is very rare. This report contributes to the differential diagnosis of ISM by demonstrating that such lymphocytic aggregates may be neoplastic. Methods: Biopsy specimens (bone marrow and gastrointestinal mucosa) of a 69 year old woman with mild blood lymphocytosis and a history of urticaria pigmentosa-like skin lesions that had disappeared a few years earlier, were investigated immunohistochemically using antibodies against CD3, CD5, CD20, CD23, CD25, CD34, CD117, chymase, and tryptase. Rearrangements of the IgH and TCRy genes were studied by seminested PCR. Mutation analysis of c-kit was performed by melting point analysis of nested PCR using amplified DNA from pooled microdissected single cells (MC and B cells) of both sites. Results: The histomorphological features of the bone marrow corresponded to that of ISM with multifocal accumulations of MC surrounded by clusters of lymphocytes of mature appearance. However, these lymphocytes revealed an aberrant immunophenotype with coexpression of CD5, CD20, and CD23, thus enabling the final diagnosis of SM with an associated clonal haematological non-MC lineage disease, in particular SM with associated B cell chronic lymphocytic leukaemia (SM-CLL). Monoclonality for both ISM and B-CLL could be confirmed by demonstrating the typical activating c-kit point mutation D816V in bone marrow MC, and a monoclonal IgH rearrangement in bone marrow B cells. Conclusions: Usually, focal accumulations of lymphocytes around MC infiltrates in the bone marrow of patients with SM are reactive in nature (lymphocytosis). However, a low grade malignant lymphoma should also be included in the differential diagnosis. We describe here the first case, to our knowledge, with synchronous diagnosis of SM and associated B-CLL. This diagnosis could only be established by application of appropriate immunohistochemical and molecular techniques, as the bone marrow histology on first investigation resembled that of typical ISM.

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“…It has been previously suspected [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91], but not systematically evaluated and proven, that Ph – MPN-B-CLL is the most common combination in patients with two different haematological neoplasms (fig. 3; online suppl.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous and Sequential Concurrent Myeloproliferative and Lymphoproliferative Neoplasms

Jonigk

Kreipe

et al. 2012

Acta Haematol

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Concurrent manifestation of two chronic-stage myeloid and lymphoid/plasmacytoid neoplasms in one patient is rare and occurs in ≤1% of patients. There has been no systematic analysis of which combinations are frequent/infrequent and whether two concurrent diseases in one patient are clonally related or represent independent diseases. We therefore characterised a series of cases from our own archive (n = 65) and collected a large number of previously reported cases of patients in whom myeloid and lymphoid/plasmacytoid neoplasms co-occurred (n = 185). The most frequent combination was Philadelphia chromosome-negative myeloproliferative neoplasm with concurrent B cell chronic lymphocytic leukaemia, accounting for approximately 50% of double-disease patients. We compared the quantity of unsorted bone marrow cell-derived JAK2^V617F and KIT^D816V alleles with the quantity of the lymphoid/plasmacytoid compartment and analysed a subfraction of cases with fluorescence in situ hybridisation. Although a common aberrant progenitor has been reported in some cases in the literature, we found evidence of two independent chronic-stage myeloid and lymphoid/plasmacytoid neoplasms.

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Hodgkin's and Castleman's disease in a patient with systemic mastocytosis

Cited by 26 publications

References 18 publications

Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease

Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease

An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL)

Simultaneous and Sequential Concurrent Myeloproliferative and Lymphoproliferative Neoplasms

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