Abstract:Hodgkin disease is a malignancy of the lymphatic system, affecting predominantly young adults. Radio and chemotherapy have allowed long‐term cure in a large portion of patients. Unfortunately, 15–20% of patients can relapse and eventually die to this disease. CD30+ Reed–Sternberg cells represent the hallmark of this disease and they can be a variable, but usually very small portion of the cellular components of the affected lymph nodes. On the other hand, it is prominent the presence of a tumour microenvironme… Show more
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