“…In addition to missing or incomplete values, shortage of data is another problem, especially for time-series omics data collected from dynamic observations. For example, capturing the dynamic interactions among growth promoting ligands, signaling proteins, histone modifications, and genes in the breast cancer microenvironment requires integrating multiple time-series omics data (e.g., proteomics and genomics ) (Shi et al, 2020). Typically these time-series datasets do not align perfectly, i.e., each omic data only have observations in few time points.…”