Hochfrequenzthermotherapie mit perfundierten Nadelapplikatoren bei 
			 der Behandlung primärer und sekundärer Lebertumoren

Hänsler, J.; Witte, Astrid; Strobel, D; Wein, Axel; Bernatik, T.; Pavel, Marianne; Müller, Wolfgang; Hahn, E. G.; Becker, Dirk

doi:10.1055/s-2003-37413

Cited by 11 publications

(11 citation statements)

References 16 publications

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“…Die Behandlungen wurden im Rahmen einer zusätzlichen systemischen Chemotherapie durchgeführt. Entsprechend den Vorgaben anderer Untersuchungen war auch in diesen Fällen nach durchgeführter First-line-Chemotherapie keine Remission eingetreten [1,2,29].…”

Section: Materials Und Methodenunclassified

“…Entscheidend für den Erfolg der Methode ist das Erreichen einer vollständigen Tumor-Nekrose [1,2,6,12]. Während der Behandlung mit perfundierten Sonden erfolgt die Regulation über die Impedanz des Gewebes in Kombination mit der verabreichten Kochsalzlösung [2 -6,12 -14].…”

Section: Introductionunclassified

“…In allen Fällen wurden Larynxmasken verwendet und eine analgetische Nachbehandlung unter stationären Bedingungen über mindestens 48 Std. durchgeführt [1,2].…”

Section: Introductionunclassified

“…In Zeitintervallen von 5 Minuten erfolgte eine maximale Energiezufuhr von 10 000 Watt. An der Spitze der 1,2 mm durchmessenden Hohlnadel wurden durch synchrone Aufheizung der NaCL-Spüllösung Temperaturen von maximal 100 8C an der Grenzfläche zum Tumorrand erreicht [2,7].…”

Section: Introductionunclassified

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Erste Erfahrungen mit der kontrastmittelverstärkten Sonographie mit Optison® bei der perkutanen Thermoablation von Lebertumoren

Jung

Clevert²,

Rupp³

2003

Rofo Fortschr Geb Rontgenstr N

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Section: Materials Und Methodenunclassified

Section: Introductionunclassified

“…In allen Fällen wurden Larynxmasken verwendet und eine analgetische Nachbehandlung unter stationären Bedingungen über mindestens 48 Std. durchgeführt [1,2].…”

Section: Introductionunclassified

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Erste Erfahrungen mit der kontrastmittelverstärkten Sonographie mit Optison® bei der perkutanen Thermoablation von Lebertumoren

Jung

Clevert²,

Rupp³

2003

Rofo Fortschr Geb Rontgenstr N

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“…There have been several reported strategies to solve this limitation of monopolar RF ablation including RF ablation with hypertonic saline (HS) preinjection (11-13), wet RF ablation (RF ablation with continuous infusion of HS through the electrode) (14-16), bipolar RF ablation (17, 18), and RF ablation using multiple probes (19-21). Among these approaches, we believe that hypertonic saline-mediated RF ablation, which includes RF ablation with HS preinjection and wet RF ablation, is seemingly a very attractive method because the injected saline could increase both the electrical and thermal conductivities, and the higher boiling points of the hypertonic saline could be helpful in avoiding the rapid boiling of liver tissue adjacent to the electrode (12, 20, 22, 23).…”

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confidence: 99%

Comparison of Wet Radiofrequency Ablation with Dry Radiofrequency Ablation and Radiofrequency Ablation Using Hypertonic Saline Preinjection: Ex Vivo Bovine Liver

et al. 2004

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ObjectiveWe wished to compare the in-vitro efficiency of wet radiofrequency (RF) ablation with the efficiency of dry RF ablation and RF ablation with preinjection of NaCl solutions using excised bovine liver.Materials and MethodsRadiofrequency was applied to excised bovine livers in a monopolar mode for 10 minutes using a 200 W generator and a perfused-cooled electrode with or without injection or slow infusion of NaCl solutions. After placing the perfused-cooled electrode in the explanted liver, 50 ablation zones were created with five different regimens: group A; standard dry RF ablation, group B; RF ablation with 11 mL of 5% NaCl solution preinjection, group C; RF ablation with infusion of 11 mL of 5% NaCl solution at a rate of 1 mL/min, group D; RFA with 6 mL of 36% NaCl solution preinjection, group E; RF ablation with infusion of 6 mL of 36% NaCl solution at a rate of 0.5 mL/min. In groups C and E, infusion of the NaCl solutions was started 1 min before RF ablation and then maintained during RF ablation (wet RF ablation). During RF ablation, we measured the tissue temperature at 15 mm from the electrode. The dimensions of the ablation zones and changes in impedance, current and liver temperature during RF ablation were then compared between the groups.ResultsWith injection or infusion of NaCl solutions, the mean initial tissue impedance prior to RF ablation was significantly less in groups B, C, D, and E (43-75 Ω) than for group A (80 Ω) (p < 0.05). During RF ablation, the tissue impedance was well controlled in groups C and E, but it was often rapidly increased to more than 200 Ω in groups A and B. In group D, the impedance was well controlled in six of ten trials but it was increased in four trials (40%) 7 min after starting RF ablation. As consequences, the mean current was higher for groups C, D, and E than for the other groups: 401 ± 145 mA in group A, 287 ± 32 mA in group B, 1907 ± 96 mA in group C, 1649 ± 514 mA in group D, and 1968 ± 108 mA in group E (p < 0.05). In addition, the volumes of RF-induced coagulation necrosis were greater in groups C and E than in group D, which was greater than in groups A and B than in group E (p < 0.05); 14.3 ± 3.0 cm3 in group A; 12.4 ± 3.8 cm3 in group B; 80.9 ± 9.9 cm3 in group C; 45.3 ± 11.3 cm3 in group D and 81.6 ± 8.6 cm3 in group E. The tissue temperature measured at 15 mm from the electrode was higher in groups C, D and E than other groups (p < 0.05): 53 ± 12℃ in group A, 42 ± 2℃ in group B, 93 ± 8℃ in group C; 79 ± 12℃ in group D and 83 ± 8℃ in group E.ConclusionWet RF ablation with 5% or 36% NaCl solutions shows better efficiency in creating a large ablation zone than does dry RF ablation or RF ablation with preinjection of NaCl solutions.

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Perioperative blood transfusions for the recurrence of colorectal cancer

Amato

Pescatori

2004

Cochrane Database of Systematic Reviews

240

192

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Hochfrequenzthermotherapie mit perfundierten Nadelapplikatoren bei der Behandlung primärer und sekundärer Lebertumoren

Abstract: RFA with wet electrodes is a safe, effective and inexpensive treatment for primary and secondary tumours of the liver, measuring less than 4 cm in diameter.

Cited by 11 publications

References 16 publications

Erste Erfahrungen mit der kontrastmittelverstärkten Sonographie mit Optison® bei der perkutanen Thermoablation von Lebertumoren

Erste Erfahrungen mit der kontrastmittelverstärkten Sonographie mit Optison® bei der perkutanen Thermoablation von Lebertumoren

Comparison of Wet Radiofrequency Ablation with Dry Radiofrequency Ablation and Radiofrequency Ablation Using Hypertonic Saline Preinjection: Ex Vivo Bovine Liver

Perioperative blood transfusions for the recurrence of colorectal cancer

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