Hoarseness in pellagra

Hiraga, Akiyuki; Kamitsukasa, Ikuo; Araki, Nobuyuki; Yamamoto, Heizaburo

doi:10.1016/j.jocn.2010.07.150

Cited by 9 publications

(4 citation statements)

References 6 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Severe alcoholism can likewise exert a negative effect on niacin production 19 – 24 . Chronic alcoholism may cause inadequate intake of protein (tryptophan) and vitamin B, inhibition of Trp 2,3‐dioxygenase activity by an NAD(P)H‐mediated allosteric mechanism, and repression of kynurenine aminotransferase and kynureninase activities by acetaldehyde through binding of their pyridoxal 5'‐phosphate cofactor and thereby lead to disturbance of the kynurenine pathway 5 …”

Section: Discussionmentioning

confidence: 99%

Pellagra Secondary to Medication and Alcoholism

Wang

et al. 2016

Nut in Clin Prac

View full text Add to dashboard Cite

Pellagra usually results from niacin deficiency and presents with the classic triad of dermatitis, diarrhea, and dementia. It is most commonly associated with malnutrition and poverty and is extremely rare in industrialized societies. Furthermore, pellagra can be induced by special clinical conditions that interfere with the intake, absorption, and metabolism of niacin. Because of its detrimental effects on health and its favorable prognosis after supplementation of nicotinamide, the importance of early diagnosis and treatment should be emphasized. Herein, we report a case of pellagra in a young alcoholic who underwent combined chemotherapy for tuberculosis. For the first time, a descriptive review of literature from 1957 to 2014 has been conducted to clarify potential etiologies of pellagra: alcoholism (35.24%, 37 articles), various medications (25.71%, 27 articles), inadequate oral intake (16.19%, 17 articles), malabsorption (13.33%, 14 articles), metabolic derangement (7.62%, 8 articles), excessive loss (0.95%, 1 article), and etiology unknown (0.95%, 1 article).

show abstract

Section: Discussionmentioning

confidence: 99%

Pellagra Secondary to Medication and Alcoholism

Wang

et al. 2016

Nut in Clin Prac

View full text Add to dashboard Cite

show abstract

“…2 In this issue of the Journal of Clinical Neuroscience, Hiraga et al present an interesting patient with pellagra who has laryngitis and hoarseness. 3 Although patients with pellagra are known to have oral lesions such as stomatitis and glossitis, this is the first report of pellagra causing laryngitis. The patient is a 67-year-old woman with chronic alcoholism.…”

Section: Introductionmentioning

confidence: 84%

Commentary: Hoarseness in pellagra

Hammond¹

2011

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…A deficiency in niacin manifests itself with the disease, pellagra [30][31][32][33]. It is frequently associated with alcoholism as well as glossitis, scarlet stomatitis, diarrhea, dermatitis, and psychosis, as well as mental deficiency.…”

Section: Discussionmentioning

confidence: 99%

The influence of B-complex vitamins upon the prolongation of prothrombin time by acetaldehyde

Catazaro

Brecher²

2013

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

Alcoholism plays a major role in the insufficient utilization or deficiency of the vitamin B-complex molecules, and the pathologies resulting therefrom. Thiamine, pyridoxamine, and folic acid, each contain primary amine functional groups, whereas nicotinamide and vitamin B12 contain amide groups, each of which are potential reactants with acetaldehyde (AcH), the primary intermediate in the metabolism of ethanol. In this current study, it is reported that prothrombin time (PT), which is prolonged in a fraction of the alcoholic population, can be modified (in the laboratory) when several B-complex vitamins and AcH are added successively to human plasma or are premixed prior to the addition to plasma. Particularly, thiamine, pyridoxamine, and folic acid, at 0.01 mol/l, when added successively with 44.7 mmol/l AcH to plasma, or when premixed prior to addition to plasma, produced a marked reduction in the anticoagulant effect of AcH. Nicotinamide had no effect on PT nor did mixtures with AcH effect PT. However, NAD, which contains a primary amine in its AMP moiety, reacted with AcH, lowering the latter's anticoagulant activity upon addition to plasma. Vitamin B12 did not affect PT. Interestingly, successive mixtures of vitamin B12 and AcH to plasma resulted in a small but statistically significant increase (P≤0.05) in the anticoagulant effect of AcH, whereas premixtures had no statistically significant effect (P>0.05). The decrease in anticoagulant activity of AcH in the presence of B-complex vitamins and NAD suggests that the primary amines in these molecules may form Schiff bases with AcH, thereby lowering both the free AcH concentration as well as the ability of the free vitamins/coenzymes to partake in essential physiological reactions.

show abstract

Hoarseness in pellagra

Cited by 9 publications

References 6 publications

Pellagra Secondary to Medication and Alcoholism

Pellagra Secondary to Medication and Alcoholism

Commentary: Hoarseness in pellagra

The influence of B-complex vitamins upon the prolongation of prothrombin time by acetaldehyde

Contact Info

Product

Resources

About