Mini ReviewHoarding disorder (HD) is defined by the Diagnostic and Statistical Manual version 5 (DSM-5) as a persistent difficulty discarding or parting with possessions, regardless of the value others may attribute to them [1]. HD raises public health concerns (e.g. squalor, dirtiness and bad odor) [2] and frequently results in house/home evictions [3]. Twenty four percent of all preventable fire fatalities occurred in hoarding households [4]. The management of HD is challenging: first, because patients' pass through multiple public services before receiving formal psychological counselling [3], further there are limited treatment options [5], and later authors highlight that the lack of knowledge about HD etiology limits the development of new treatment approaches. In this article, we review different evidence-based etiological models of HD [6]. The objective of this work is to make a brief review of published hypotheses about HD aetiology.Genetic studies revealed that the heritability of HD [7] can explain 55-77% of the variance in HD. According to Monzani et al. [8] one latent heritable factor could be etiological factor for three obsessive-compulsive spectre disorders (OCD, HD and body dysmorphic disorder). Timpano et al. [9] argued that variance in the Brain-derived neurotrophic factor (BDNF) coding gene could be such a factor. The BDNF is a protein which regulates the neurogenesis in adults [10]. Variance in BDNF is observed also in OCD, depression, body dysmorphic disorder and other conditions associated with impulse/emotion regulation. This study was carried out within the framework of the general etiological hypothesis that HD is an exaggerated form of a normal evolutionary behavior of collecting and saving possessions. The study also reported the association between BDNF gene variance, obesity and HD.At the level of brain functions, neuroimaging and neuropsychological studies in hoarding behavior have yielded equivocal results. The most common finding among the brain imaging studies was decreased metabolism in the lateral orbit frontal cortex and anterior cingulate cortex. Findings of neuropsychological studies are difficult to meta-analyse due to difference in targeted functions and methods used [11]. However, people with HD without OCD have poorer delayed visual and verbal recall and used less effective organizational strategies for visual recall; less confidence in their memory and a greater level of worry concerning the potentially catastrophic consequences of forgetting; slower reaction time and increased impulsivity [11]. A well-validated battery of neuropsychological tests revealed only a difference in planning/problem-solving in people with HD without OCD compared to controls. It is possible that people with HD display decision-making difficulties specific only to items of personal significance, which would not be captured by these standard neuropsychological tasks [11]. Frost & Hartl [12] proposed a cognitive model of HD, which includes (1) information processing deficits; (2) problems in ...