HNO Generation From NO, Nitrite, Inorganic or Organic Nitrosyls, and Crosstalk With H2S

Ivanović-Burmazović, I.

doi:10.1016/b978-0-12-800934-5.00005-0

Cited by 10 publications

(19 citation statements)

References 83 publications

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“…482 In summary, HSNO remains the chemically most plausible nitrosating agent that can react with cysteines (Chart 21 and Figure 15) and engage in transnitrosation reactions. 482,483…”

Section: Chemical Biology Of H2smentioning

confidence: 99%

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Chemical Biology of H₂S Signaling through Persulfidation

et al. 2017

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Signaling by HS is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of HS. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of HS and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.

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“…482 In summary, HSNO remains the chemically most plausible nitrosating agent that can react with cysteines (Chart 21 and Figure 15) and engage in transnitrosation reactions. 482,483…”

Section: Chemical Biology Of H2smentioning

confidence: 99%

“…Even if formed, SSNO – would readily react with thiols to form HSNO . In summary, HSNO remains the chemically most plausible nitrosating agent that can react with cysteines (Chart and Figure ) and engage in transnitrosation reactions. , …”

Section: Chemical Biology Of H2smentioning

confidence: 99%

Chemical Biology of H₂S Signaling through Persulfidation

et al. 2017

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“…It is thought that the reduction of NO· by specific Fe(II)-heme and high-spin Fe(II) or Mn(II) complexes makes them potential sources of endogenous HNO in living cells (17). HNO is a highly reactive and short-lived molecule that self-quenches via dimer formation to yield nitrous oxide (N 2 O) (18).…”

Section: Introductionmentioning

confidence: 99%

“…Although our understanding of the biological impact of HNO is not yet complete, HNO appears to be characterized by a chemical reactivity and biogenesis profile that is distinct from that of NO·. It is thought that the reduction of NO· by specific Fe(II)-heme and high-spin Fe(II) or Mn(II) complexes makes them potential sources of endogenous HNO in living cells ( 17 ). HNO is a highly reactive and short-lived molecule that self-quenches via dimer formation to yield nitrous oxide (N 2 O) ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

Peng

Shen

Edmonds

et al. 2017

mSphere

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Hydrogen sulfide (H2S) is a toxic molecule and a recently described gasotransmitter in vertebrates whose function in bacteria is not well understood. In this work, we describe the transcriptomic response of the major human pathogen Staphylococcus aureus to quantified changes in levels of cellular organic reactive sulfur species, which are effector molecules involved in H2S signaling. We show that nitroxyl (HNO), a recently described signaling intermediate proposed to originate from the interplay of H2S and nitric oxide, also induces changes in cellular sulfur speciation and transition metal homeostasis, thus linking sulfide homeostasis to an adaptive response to antimicrobial reactive nitrogen species.

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“…However, an inner-sphere electron transfer from the metal ion to the coordinated NO group in the presence of an electron-rich ligand (as sixth ligand) will consequently increase the electron density on the central metal ion which, in turn, stabilizes Mn(III) form of the complex and contributes to the HNO/NO − donation. 27 In the case of HBF 4 , it acts as the H + source to polarize the NO group as well as the BF 4…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Can a Nitrosyl of a Mn(II)–Porphyrin Complex Release Nitroxyl/HNO?

et al. 2021

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In general, the nitrosyl complexes of Mn(II)−porphyrinate having the {Mn(NO)} 6 configuration are not considered as HNO or nitroxyl (NO − ) donors because of [Mn I −NO + ] nature. A nitrosyl complex of Mn(II)− porphyrin, [Mn(TMPP 2− )(NO)], 1 [TMPPH 2 = 5,10,15,20-tetrakis-4-methoxyphenylporphyrin], is shown to release HNO in the presence of HBF 4 . It is evidenced from the characteristic reaction of HNO with triphenylphosphine and isolation of the [(TMPP 2− )Mn III (H 2 O) 2 ](BF 4 ), 2. This is attributed to the fact that H + from HBF 4 polarizes the NO group whereas the BF 4 − interacts with metal ion to stabilize the Mn(III) form. These two effects cooperatively result in the release of HNO from complex 1. In addition, complex 1 behaves as a nitroxyl (NO − ) donor in the presence of [Fe(dtc) 3 ] (dtc = diethyldithiocarbamate anion) and [Fe(TPP)(Cl)] (TPP = 5,10,15,20-tetraphenylporphyrinate) to result in [Fe(dtc) 2 (NO)] and [Fe(TPP)(NO)], respectively.

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HNO Generation From NO, Nitrite, Inorganic or Organic Nitrosyls, and Crosstalk With H2S

Cited by 10 publications

References 83 publications

Chemical Biology of H₂S Signaling through Persulfidation

Chemical Biology of H₂S Signaling through Persulfidation

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

Can a Nitrosyl of a Mn(II)–Porphyrin Complex Release Nitroxyl/HNO?

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HNO Generation From NO, Nitrite, Inorganic or Organic Nitrosyls, and Crosstalk With H2S

Cited by 10 publications

References 83 publications

Chemical Biology of H2S Signaling through Persulfidation

Chemical Biology of H2S Signaling through Persulfidation

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

Can a Nitrosyl of a Mn(II)–Porphyrin Complex Release Nitroxyl/HNO?

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Chemical Biology of H₂S Signaling through Persulfidation

Chemical Biology of H₂S Signaling through Persulfidation