HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study

Mandato, Vincenzo Dario; Farnetti, Enrico; Torricelli, Federica; Abrate, M; Casali, Bruno; Ciarlini, Gino; Pirillo, Debora; Gelli, Maria Carolina; Nicoli, Davide; Grassi, Mario; Sala, Giovanni Battista La; Palomba, Stefano

doi:10.1186/s12885-015-1246-5

Cited by 16 publications

(7 citation statements)

References 41 publications

(62 reference statements)

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“…Hyperestrogenism characterizes early menarche, late menopause, nulliparity, estrogen only hormone replacement therapy and obesity that are well known risk factors for type I EC 5 , 6 . Several data related to the genetic risk was also reported 7 - 9 . Single nucleotide polymorphisms (SNPs) of aromatase (CYP19A1) influenced susceptibility to EC, particularly among older and obese patients 7 .…”

Section: Introductionmentioning

confidence: 98%

Prognostic Impact of ABO Blood Group on Type I Endometrial Cancer Patients- Results from Our Own and Other Studies

et al. 2017

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Objectives: The ABO blood group antigens were found on most epithelial cells and in secretions. In the normal endometrium there is a variable expression of histo-blood group and related antigens suggesting a hormonal regulation. A relationship between ABO blood groups and endometrial cancer has been investigated with contradictory results. In this study we investigated the influence of blood types on clinical and pathological characteristics of endometrial cancer patients.Method: Retrospective cohort study. Clinical and pathological data were extrapolated and their association with blood groups were assessed.Results: A total of 203 type I endometrial cancer patients were included in the final analysis. Univariate analysis indicated that a lower frequency of G3 undifferentiated tumors was observed in patients with A blood group (P=0.027). Multivariate analysis, including also clinical features such as Age, BMI, parity, hypertension and diabetes confirmed that patients with A group present a lower risk of G3 tumors in comparison with not A patients. (OR=0.32, P=0.011).Conclusions: Patients with A genotype have a lower risk to develop G3 type I endometrial cancer. ABO blood group might represent a useful, easy access and cheap biomarker for patients' selection and for management personalization of endometrial cancer patients.

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Section: Introductionmentioning

confidence: 98%

Prognostic Impact of ABO Blood Group on Type I Endometrial Cancer Patients- Results from Our Own and Other Studies

et al. 2017

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“…Meta-analysis of large samples also confirmed this result 26 . At the same time, the HNF1B gene can independently affect the prognosis of endometrial tumors 27 .…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of HNF1B mRNA in Human Cancers Based on Data Mining

Nie¹,

Wang²,

Wang³

et al. 2020

Int. J. Med. Sci.

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Cancer incidence is rapidly growing, and cancer is the leading cause of death worldwide in the 21st century. Hepatocyte nuclear factor 1B (HNF1B) is a transcription factor that involves the growth and development of multiple organs. The aim of this study was to explore the significance of HNF1B in human cancer by an integrative analysis of online databases. The UALCAN database, cBio cancer genomics portal, Cancer Regulome tools, Kaplan-Meier plotter and Tumor IMmune Estimation Resource (TIMER) website were used to perform the corresponding analysis. The results showed that HNF1B is dysregulated in various cancers and associated with the differential overall survival of cancer patients. HNF1B showed many mutation forms and high mutation levels in different cancer types. In addition, we found that HNF1B interacted with different genes in multiple aspects. Moreover, HNF1B expression is associated with many immune cell infiltration levels and influences the prognostic prediction of immune cells in some kinds of cancers. In conclusion, HNF1B plays a significant role in cancer and may be a potential target for cancer immunotherapy.

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“…HNF1 homeobox B (HNF1B) encodes a transcription factor and has been shown to play a role in cell development. SNPs in the HNF1B gene region have been previously associated with pancreatic (72), prostate (12,(73)(74)(75)(76)(77)(78)(79), ovarian (80)(81)(82), testicular (83), and Cancer Epidemiology, Biomarkers & Prevention endometrial (84)(85)(86) cancers. Expression of HNF1B has been associated with prognosis in hepatocellular carcinoma (87) and renal cell carcinoma (88).…”

Section: Discussionmentioning

confidence: 99%

Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans

Jones

Bradford

Amos

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Identifying genetic variants with pleiotropic associations across multiple cancers can reveal shared biologic pathways. Prior pleiotropic studies have primarily focused on European-descent individuals. Yet population-specific genetic variation can occur, and potential pleiotropic associations among diverse racial/ethnic populations could be missed. We examined cross-cancer pleiotropic associations with lung cancer risk in African Americans. Methods: We conducted a pleiotropic analysis among 1,410 African American lung cancer cases and 2,843 controls. We examined 36,958 variants previously associated (or in linkage disequilibrium) with cancer in prior genome-wide association studies. Logistic regression analyses were conducted, adjusting for age, sex, global ancestry, study site, and smoking status. Results: We identified three novel genomic regions significantly associated (FDR-corrected P <0.10) with lung cancer risk (rs336958 on 5q14.3, rs7186207 on 16q22.2, and rs11658063 on 17q12). On chromosome16q22.2, rs7186207 was significantly associated with reduced risk [OR ¼ 0.43; 95% confidence interval (CI), 0.73-0.89], and functional annotation using GTEx showed rs7186207 modifies DHODH gene expression. The minor allele at rs336958 on 5q14.3 was associated with increased lung cancer risk (OR ¼ 1.47; 95% CI, 1.22-1.78), whereas the minor allele at rs11658063 on 17q12 was associated with reduced risk (OR ¼ 0.80; 95% CI, 0.72-0.90). Conclusions: We identified novel associations on chromosomes 5q14.3, 16q22.2, and 17q12, which contain HNF1B, DHODH, and HAPLN1 genes, respectively. SNPs within these regions have been previously associated with multiple cancers. This is the first study to examine cross-cancer pleiotropic associations for lung cancer in African Americans. Impact: Our findings demonstrate novel cross-cancer pleiotropic associations with lung cancer risk in African Americans.

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HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study

Cited by 16 publications

References 41 publications

Prognostic Impact of ABO Blood Group on Type I Endometrial Cancer Patients- Results from Our Own and Other Studies

Prognostic Impact of ABO Blood Group on Type I Endometrial Cancer Patients- Results from Our Own and Other Studies

Integrative Analysis of HNF1B mRNA in Human Cancers Based on Data Mining

Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans

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