HNF1A gene p.I27L is associated with co-existing preeclampsia in gestational diabetes mellitus

Beysel, Selvihan; Pınarlı, Ferda Alpaslan; Eyerci, Nilnur; Kızılgül, Muhammed; Hepşen, Sema; Alhan, Ali; Kan, Seyfullah; Çalışkan, Mustafa; Bozkurt, Erhan; Çakal, Erman

doi:10.1080/09513590.2019.1698023

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…Some studies suggest that TNF-α, IL-6, and C-reactive protein (CRP) are independent risk factors for PE in women with GDM (94,175,176), and others suggest that in addition to the increased level of CRP, the imbalance of Interleukin-17 /Interleukin-35 may also be involved in the pathogenesis of GDM complicated with PE (177). Genetic variants are also associated with PE in women with GDM, the MIR146Ars2910164CC genotype, HNF1αgene p. I27L TT genotype, and ACE I / D polymorphism DD genotype was significantly higher in women with GDM complicated with PE (178)(179)(180). Obesity is the main influencing factor of PE in women with GDM in this paper.…”

Section: Mechanism and Predictive Markersmentioning

confidence: 99%

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Yang

2022

Front. Cardiovasc. Med.

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Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors and pathophysiological changes. Evidence from previous studies suggests that the incidence of PE is significantly increased in women with GDM, but whether GDM is independently related to the occurrence of PE has remained controversial. GDM complicated by PE further increases perinatal adverse events with greater impact on the future maternal and offspring health. Identify factors associated with PE in women with GDM women, specifically those that are controllable, is important for improving pregnancy outcomes. This paper provides the findings of a review on the correlation between GDM and PE, factors associated with PE in women with GDM, possible mechanisms, and predictive markers. Most studies concluded that GDM is independently associated with PE in singleton pregnancy, and optimizing the treatment and management of GDM can reduce the incidence of PE, which is very helpful to improve pregnancy outcomes.

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Section: Mechanism and Predictive Markersmentioning

confidence: 99%

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Yang

2022

Front. Cardiovasc. Med.

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“…FTO rs9939609 and rs9940128 variants are closely related to hyperglycemia, insulin resistance and diabetes mellitus in several populations. 56 , 57 , 58 , 59 , 60 …”

Section: Diabetes Mellitusmentioning

confidence: 99%

The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

et al. 2021

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N6-methyladenosine (m6A) RNA methylation is an emerging area of epigenetics, which is a reversible and dynamic modification mediating by ‘writers’ (methylase, adding methyl groups, METTL3, METTL14, and WTAP), ‘erasers’ (demethylase, deleting methyl groups, FTO and ALKBH5), and ‘readers’ (YTHDF1-3, YTHDC1 and YTHDC2). Recent studies in human, animal models and cell levels have disclosed a critical role of m6A modification in regulating the homeostasis of metabolic processes and cardiovascular function. Evidence from these studies identify m6A as a candidate of biomarker and therapeutic target for metabolic abnormality and cardiovascular diseases (CVD). Comprehensive understanding of the complexity of m6A regulation in metabolic diseases and CVD will be helpful for us to understand the pathogenesis of CVD. In this review, we discuss the regulatory role of m6A in metabolic abnormality and CVD. We will emphasize the clinical relevance of m6A dysregulation in CVD.

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“…This result was not reported in the literature, and it may suggest the role of some sex-specific hormonal pathways, regulated by the HNF1A transcriptional machinery, in the metabolism of lipids. In this context, a recent study demonstrated that rs1169288 minor genotype is associated with an increased risk of preeclampsia, a pregnancy complication characterized by high blood pressure and signs of damage in liver [ 47 ]. Interestingly, Lee et al reported an increased cholesterol biosynthesis and accumulation in the women with preeclampsia [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Dallali

Hechmi

Morjane

et al. 2022

Diabetol Metab Syndr

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Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and its components through an association study in the Tunisian population as well as by a meta-analysis. Methods A total of 594 Tunisian individuals were genotyped for three variants (rs1169288, rs2464196 and rs735396) located in HNF1A gene using KASPar technology. Statistical analyses were performed with R software. The association was furthermore evaluated through a meta-analysis of our results with those obtained in a Moroccan population. Results Our results showed no association between HNF1A variants and MetS in the Tunisian population. However, a significant association was observed between the variant rs735396 and a higher waist circumference. The stratified analysis according to the sex highlighted a significant association between the variant rs1169288 and high cholesterol levels only in women. Similarly, Haplotype analysis showed an association between the HNF1A minor haplotype and high total cholesterol mainly in women. Finally, our meta-analysis showed no association between HNF1A variants and MetS. Conclusions Our findings exclude the involvement of the three HNF1A variants rs1169288, rs2464196 and rs735396 in the susceptibility to MetS in our studied Tunisian population but emphasize the role of these variants in the cholesterol homeostasis with sex-specific differences, which may serve to rise clinical consideration to early statin therapy in women carrying these genetic variants.

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HNF1A gene p.I27L is associated with co-existing preeclampsia in gestational diabetes mellitus

Cited by 10 publications

References 29 publications

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

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