HMNC1 gene polymorphism associated with postpartum depression

Miranda, Débora Marques de; Campos, Sérgio Vale Aguiar; Figueira, Patrícia; Corrêa, Humberto; Romano-Silva, Marco Aurélio

doi:10.1590/1516-4446-2013-3507

Cited by 12 publications

(9 citation statements)

References 5 publications

(4 reference statements)

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“…Although the results were no longer significant after accounting for multiple comparisons, 101 the association between the rs2891230 polymorphism of the HMCN1 gene and PPD was confirmed by a subsequent candidate gene study. 102 Similarly, a genome-wide association study yielded a third-trimester biomarker panel of 116 transcripts that predicted PPD onset with 88% accuracy in both the discovery sample of 62 women and the independent replication sample of 24 women. 103 Of these transcripts, ESR1 was the only enriched transcription factor binding site, again potentially implicating estrogen in the pathogenesis of PPD.…”

Section: Alternative Biological Modelsmentioning

confidence: 99%

The role of reproductive hormones in postpartum depression

2014

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Despite decades of research aimed at identifying the causes of postpartum depression (PPD), PPD remains common, and the causes are poorly understood. Many have attributed the onset of PPD to the rapid perinatal change in reproductive hormones. Although a number of human and non-human animal studies support the role of reproductive hormones in PPD, several studies have failed to detect an association between hormone concentrations and PPD. The purpose of this review is to examine the hypothesis that fluctuations in reproductive hormone levels during pregnancy and the postpartum period trigger PPD in susceptible women. We discuss and integrate the literature on animal models of PPD and human studies of reproductive hormones and PPD. We also discuss alternative biological models of PPD to demonstrate the potential for multiple PPD phenotypes and to describe the complex interplay of changing reproductive hormones and alterations in thyroid function, immune function, HPA axis function, lactogenic hormones, and genetic expression that may contribute to affective dysfunction. There are three primary lines of inquiry that have addressed the role of reproductive hormones in PPD: non-human animal studies, correlational studies of postpartum hormone levels and mood symptoms, and hormone manipulation studies. Reproductive hormones influence virtually every biological system implicated in PPD, and a subgroup of women seem to be particularly sensitive to the effects of perinatal changes in hormone levels. We propose that these women constitute a “hormone-sensitive” PPD phenotype, which should be studied independent of other PPD phenotypes to identify underlying pathophysiology and develop novel treatment targets.

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Section: Alternative Biological Modelsmentioning

confidence: 99%

The role of reproductive hormones in postpartum depression

2014

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“…Comasco et al (2011b) and AlvimSoares et al( 2013) replicated this finding for COMT polymorphisms during the sixth and eighth weeks postpartum, respectively. In addition, two other studies also found positive associations during the beginning of the postpartum period for other SNPs (Alvim-Soares et al, 2014;Engineer et al, 2013).…”

Section: Discussionmentioning

confidence: 77%

“…Regarding the period of assessment, studies evaluating specific polymorphisms (Alvim-Soares et al, 2013;Alvim-Soares et al, 2014;Binder et al, 2010;Engineer et al, 2013;Pinheiro et al, 2013;Sanjuan et al, 2008) reported associations similar to those found in a population study (Forty et al, 2006), suggesting a greater genetic influence in depressive episodes that are present between 6 and 8 weeks postpartum.…”

Section: Discussionmentioning

confidence: 78%

“…In addition, one study evaluated depression during pregnancy and the postpartum period using a diagnostic interview (Structured Clinical Interview for DSM-IV, SCID) along with a severity measure (7-Hamilton Rating Scale for Depression, HRSD17) (Binder et al, 2010). Five studies also combined a screening tool and a diagnostic tool for postpartum depression using EPDS along with the Diagnostic Interview for Genetics Studies (DIGS) (Sanjuan et al, 2008), the Mini International Neuropsychiatry Interview (MINI) (Alvim-Soares et al, 2014;Figueira et al, 2010;Pinheiro et al, 2013) or SCID (Gelabert et al, 2012). Only one study used The World Health Organization Composite International Diagnostic interview -short form (CIDI-SF) (Mitchell et al, 2011) to diagnose postpartum depression.…”

Section: Molecular Genetics Studies Examining Specific Genetic Polymomentioning

confidence: 99%

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The Influence of genetic factors on peripartum depression: A systematic review

Figueiredo

Parada

Araújo

et al. 2015

Journal of Affective Disorders

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“…PRKCB is involved in the signal transduction pathways that regulate the HPA axis(Shelton 2007.) No other studies have investigated this haplotype in association with PND to date and further study in other sample populations are required to determine its utility as a predictive marker.Hormones of the Reproductive SystemEstrogen has long been thought to play a role in the aetiology of PND and associations between genetic polymorphisms that affect estrogenic function and PND have been reported(Mahon et al 2009;Alvim-Soares et al 2014). Following the earlier reported genome wide linkage study byMahon et al (2009), a smaller targeted study by Alvim-Soares et al (2014) also reported an association between SNPs in the hemicentin-1 gene and PND.…”

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confidence: 99%

A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression

Elwood

Murray

Bell

et al. 2019

Journal of Affective Disorders

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Background Postnatal depression (PND) is common, affects the health of the mother, the development of the infant and places a large financial burden on services. Genetic and epigenetic biomarkers for PND could potentially improve the accuracy of current antenatal screening approaches. The aim of this systematic review is to report on the evidence for an association between genetic or epigenetic factors and postnatal depression. Method A systematic search of five databases (Medline, EMBASE, PILOT, PsychINFO and SCOPUS) was carried out using the following (MeSh) terms and keywords: postpartum, depression, postnatal depression, genetics, genetic polymorphisms and epigenetics. Inclusion criteria were applied and quality of studies was assessed using guidelines from the HuGE Review Handbook (Little & Higgins 2006). Results Following removal of duplicate articles, 543 remained; of these 37 met the inclusion criteria. Positive associations have been reported between PND and polymorphisms in the HMNC1, COMT, MAOT, PRKCB, ESR1, SLC6A4 genes in the presence of stressful life events, the BDNF gene when the postnatal period occurs during autumn and winter months and the OXT and OXTR genes in the presence of childhood adversity experienced by the mother. 3 Epigenetic interactions with genotype, estrogen, and childhood adversity were identified that are predictive of PND. Limitations The number of studies investigating some of the markers was small and grey literature was not included. Conclusion This review highlights the importance of examining the interaction between epigenetic, genetic, hormonal and environmental factors in order to fully understand the risk factors for PND and to improve the accuracy of current antenatal and early postnatal screening procedures. Women susceptible to PND appear to have heightened epigenetic sensitivity to the physiological changes of childbirth or to environmental factors conferred by genotype.

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HMNC1 gene polymorphism associated with postpartum depression

Cited by 12 publications

References 5 publications

The role of reproductive hormones in postpartum depression

The role of reproductive hormones in postpartum depression

The Influence of genetic factors on peripartum depression: A systematic review

A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression

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