HMGB1-Mediated Cell Death—A Crucial Element in Post-Hepatectomy Liver Failure
Laura Brunnthaler,
Thomas G. Hammond,
David Pereyra
et al.
Abstract:Liver resection (LR) is the primary treatment for hepatic tumors, yet posthepatectomy liver failure (PHLF) remains a significant concern. While the precise etiology of PHLF remains elusive, dysregulated inflammatory processes are pivotal. Therefore, we explored the theragnostic potential of extracellular high-mobility-group-box protein 1 (HMGB1), a key damage-associated molecular pattern (DAMP) released by hepatocytes, in liver recovery post LR in patients and animal models. Plasma from 96 LR patients and live… Show more
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