HMGB1 inhibition reduces TDI-induced occupational asthma through ROS/AMPK/autophagy pathway

Meng, Xiangjing; Guo, Sumei; Zhang, Xiaoxia; Jiao, Bo; Yang, Xiaohan; Li, Ming; Li, Chao; He, Jin; Chen, Shangya; Peng, Cheng; Shao, Hua; Jia, Qiang

doi:10.1016/j.ecoenv.2023.115575

Cited by 4 publications

(2 citation statements)

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“…While inhibition of HMGB1 reduces the lung inflammatory cell infiltration, goblet cell proliferation, and airway mucus production to improve asthma. 89 Accordingly, HMGB1 plays an important role in asthma.…”

Section: The Role and Related Pathways Of Hmgb1 In Asthmamentioning

confidence: 99%

“…Moreover, HMGB1, as a pro‐inflammatory factor, is secreted by bronchial epithelial cells and drives the release of inflammatory cytokines. While inhibition of HMGB1 reduces the lung inflammatory cell infiltration, goblet cell proliferation, and airway mucus production to improve asthma 89 . Accordingly, HMGB1 plays an important role in asthma.…”

Section: The Role and Related Pathways Of Hmgb1 In Asthmamentioning

confidence: 99%

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High‐mobility group box 1 emerges as a therapeutic target for asthma

Yang,

Li,

Hou

et al. 2023

Immunity Inflam & Disease

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High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.

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Section: The Role and Related Pathways Of Hmgb1 In Asthmamentioning

confidence: 99%

Section: The Role and Related Pathways Of Hmgb1 In Asthmamentioning

confidence: 99%