HMGB1 as a predictor of infarct transmurality and functional recovery in patients with myocardial infarction

Abstract

Abstract. Andrassy M, Volz HC, Riedle N, Gitsioudis G, Seidel C, Laohachewin D, Zankl AR, Kaya Z, Bierhaus A, Giannitsis E, Katus HA, Korosoglou G (University of Heidelberg, Heidelberg, Germany). HMGB1 as a predictor of infarct transmurality and functional recovery in patients with myocardial infarction. J Intern Med 2011; 270: 245-253.Objectives. High-mobility group box 1 (HMGB1) protein is an innate danger signal for the initiation of host defence and tissue repair. The aim of this study was to analyse serum HMGB1 concentration and its correlation with infarct transmurality and functional recovery in patients with ST-elevation (STEMI) and non-ST-elevation myocardial infarction (NSTEMI).Design. We prospectively examined patients with firsttime STEMI (n = 46) or NSTEMI (n = 49), treated according to current guidelines. Contrast-enhanced cardiac magnetic resonance imaging was performed 2-4 days after infarction for the estimation of infarct transmurality and was repeated after 6 months for the estimation of residual left ventricular function. HMGB1 was measured 2-4 days after infarction.Results. High-mobility group box 1 concentration was related to infarct size and to residual ejection fraction in patients with STEMI (r 2 = 0.81 and r 2 = 0.40, respectively, P < 0.001 for both) and NSTEMI (r 2 = 0.74 and r 2 = 0.25, respectively, P < 0.001 for both). Receiver operating characteristic (ROC) curvederived cut-off values of 6.2 and 5.9 ng mL )1 for patients with STEMI and NSTEMI, respectively, were predictive of infarct transmurality greater than 75% (STEMI: area under the curve (AUC) = 0. Conclusion. High-mobility group box 1 serum levels represent a highly valuable surrogate marker for infarct transmurality and for the prediction of residual left ventricular function after MI.

<i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

“…12,32) Previous studies have shown that HMGB1 functions as a pro-inflammatory cytokine in certain cardiovascular diseases, and it was related to the severity of coronary artery disease. 33,34) Yao, et al demonstrated that myocardial expression of HMGB1 significantly increased in rats with acute MI. 35) High serum levels of HMGB1 may cause cardiac inflammation and left ventricular dysfunction after MI.…”

“…This is because its active release by mononuclear cells and passive release from necrotic or damaged cells. 34) It has been reported that there are several patents proposed for controlling the production, secretion and neutralization of HMGB1 and consequently the inflammatory process. Among them, anti-HMGB1 antibodies and HMGB-A box as a competitive antagonist of HMGB1 are the most reliable methods to regulate HMGB1 directly.…”

Critical role of RAGE and HMGB1 in inflammatory heart disease

“…Our previous work has focused on the role of HMGB1 in various cardiac and metabolic stress models characterizing HMGB1 as an important initiator of inflammation and fibrosis (6,22,23).…”

Exendin-4 attenuates myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein expression

“…HMGB1 has been identified as a novel pro--inflammatory cytokine in several cardiovascular diseases [3][4][5][6]. Recently, HMGB1 has been found to function as an early pro-inflammatory mediator during myocardial ischemia and reperfusion (I/R), as well as some classical early pro-inflammatory Gangying Hu et al, Exendin-4 and HMGB1 cytokine such as tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and could promote the release of TNF-a and IL-6, whereas HMGB1 A box peptide (a specific HMGB1 antagonist) could protect against myocardial I/R injury and inhibit the release of TNF-a and IL-6 [3], while inflammatory response is considered to be a critical factor of myocardial I/R injury [7,8].…”