HMGA2 Modulates the TGFβ/Smad, TGFβ/ERK and Notch Signaling Pathways in human Lens Epithelial-Mesenchymal Transition.

Hou, Min; Bao, Xuanwen; Luo, Furong; Chen, X; Liu, L; Wu, Mingxing

doi:10.2174/1566524018666180705104844

Cited by 12 publications

(12 citation statements)

References 44 publications

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“…High mobility group AT-hook 2 (HMGA2) was among the identified target genes. According to the literature, HMGA2 mediates epithelial-mesenchymal transition (EMT) and regulates transcription factors linking various signaling pathways, such as the TGF-β and MAPK signaling pathways, to regulators of tumor invasiveness and metastasis (31). miR-18a regulates metastasis in gastric cancer (32), colon cancer (33), breast cancer (34), HCC and nasopharyngeal carcinoma (35,36).…”

Section: Discussionmentioning

confidence: 99%

Circulating plasma exosomal miRNA profiles serve as potential metastasis‑related biomarkers for hepatocellular carcinoma

et al. 2021

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Exosomes carry functional molecules that can regulate cancer progression. Understanding the function of exosomal markers may provide invaluable insights into the mechanism of metastasis in hepatocellular carcinoma (HCC). The aim of the present study was to identify metastasis-associated microRNAs (miRNAs/miRs) expressed in plasma exosomes. A miRNA microarray and reverse transcription-quantitative PCR were used to analyze the plasma exosome miRNA expression profiles of patients with metastatic or non-metastatic HCC. Receiver operating characteristic (ROC) curve and Kaplan-Meier analyses were used to evaluate the predictive performance and prognostic efficacy of candidate miRNAs identified in the Gene Expression Omnibus database (dataset accession no. GSE67140). Bioinformatics analysis was used to examine the role of exosomal miRNAs in HCC metastasis. A total of 32 miRNAs were differentially expressed in plasma exosomes of patients with metastatic HCC compared with in those of patients with non-metastatic HCC. Additionally, the expression levels of six miRNAs were consistent between plasma exosome samples and matched tissue samples. ROC analysis demonstrated that miR-18a, miR-27a and miR-20b could discriminate metastatic HCC from non-metastatic HCC. Furthermore, the prognostic efficacy of the combination of three miRNAs (miR-18a, miR-20b and miR-221) was superior to that of individual miRNAs. Survival analysis demonstrated that high expression levels of the candidate miRNAs were associated with poor prognosis. Bioinformatics analysis indicated that the potential target genes of these miRNAs were involved in biological processes, molecular functions and cellular components that were associated with metastasis. The present findings suggested that these exosomal miRNAs may serve important roles in HCC lung metastasis and could represent a complementary clinical tool for the assessment of HCC prognosis.

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Section: Discussionmentioning

confidence: 99%

Circulating plasma exosomal miRNA profiles serve as potential metastasis‑related biomarkers for hepatocellular carcinoma

et al. 2021

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“…Meanwhile, after knocking out HMGB1 in mice, the expression of TGF-β is weakened through induction of AGE-BSA dependent RAGE pathway. And the high-mobility group protein 2 (HMGA 2) can be induced by AGEs in HMGA2-knockout mice, which plays a role in inhibiting the formation of reactive oxygen species (ROS) and the activation of p38MAPK (Hou et al 2018). Furthermore, Huang et al (2013) confirmed that neuroglioma associated protein-2 (CLIPR-2) participated in the TIF progress through ERK1/2 signaling pathway in the human proximal tubule cells (HK-2).…”

Section: Renal Epithelial-mesenchymal Transition and Diabetic Renal Fibrosismentioning

confidence: 91%

A Glimpse of the Mechanisms Related to Renal Fibrosis in Diabetic Nephropathy

Zeng

Xiao

Sun

2019

Advances in Experimental Medicine and Biology

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Diabetic nephropathy (DN) is a common kidney disease in people with diabetes, which is also a serious microvascular complication of diabetes and the main cause of end-stage renal disease (ESRD) in developed and developing countries. Renal fibrosis is a finally pathological change in DN. Nevertheless, the relevant mechanism of cause to renal fibrosis in DN is still complex. In this review, we summarized that the role of cell growth factors, epithelial-mesenchymal transition (EMT) in the renal fibrosis of DN, we also highlighted the miRNA and inflammatory cells, such as macrophage, T lymphocyte, and mastocyte modulate the progression of DN. In addition, there are certain other mechanisms that may yet be conclusively defined. Recent studies demonstrated that some of the new signaling pathways or molecules, such as Notch, Wnt, mTOR, Epac-Rap-1 pathway, may play a pivotal role in the modulation of ECM accumulation and renal fibrosis in DN. This review aims to elucidate the mechanism of renal fibrosis in DN and has provided new insights into possible therapeutic interventions to inhibit renal fibrosis and delay the development of DN. Keywords Renal fibrosis • Diabetic nephropathy • TGF-β • Epithelial-mesenchymal transition • miRNA Ling-Feng Zeng and Ying Xiao contributed equally to this work.

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“…Activation of the PI3K/AKT/mTOR signaling pathway is crucial for EMT processes, which includes cancer cells invasion and migration [166]. Tan et al reported that HMGA2 silencing decreases proliferation of acute myeloid leukemia cells by reducing phosphorylation of AKT and mTOR ( Figure 5D) [93].…”

Section: The Pi3k/akt/mtor Pathwaymentioning

confidence: 98%

HMGA2 as a Critical Regulator in Cancer Development

Mansoori

Mohammadi

Ditzel

et al. 2021

Genes

113

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The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in embryonic stem cells during embryogenesis, while its expression is more limited at later stages of development and in adulthood. Importantly, HMGA2 is re-expressed in nearly all human malignancies, where it promotes tumorigenesis by multiple mechanisms. HMGA2 increases cancer cell proliferation by promoting cell cycle entry and inhibition of apoptosis. In addition, HMGA2 influences different DNA repair mechanisms and promotes epithelial-to-mesenchymal transition by activating signaling via the MAPK/ERK, TGFβ/Smad, PI3K/AKT/mTOR, NFkB, and STAT3 pathways. Moreover, HMGA2 supports a cancer stem cell phenotype and renders cancer cells resistant to chemotherapeutic agents. In this review, we discuss these oncogenic roles of HMGA2 in different types of cancers and propose that HMGA2 may be used for cancer diagnostic, prognostic, and therapeutic purposes.

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HMGA2 Modulates the TGFβ/Smad, TGFβ/ERK and Notch Signaling Pathways in human Lens Epithelial-Mesenchymal Transition.

Abstract: This study indicated that HMGA2 functions as a shared effector in TGFβ2- induced lens fibrosis, modulating the signaling network necessary for EMT in a positive feedback loop.

Cited by 12 publications

References 44 publications

Circulating plasma exosomal miRNA profiles serve as potential metastasis‑related biomarkers for hepatocellular carcinoma

Circulating plasma exosomal miRNA profiles serve as potential metastasis‑related biomarkers for hepatocellular carcinoma

A Glimpse of the Mechanisms Related to Renal Fibrosis in Diabetic Nephropathy

HMGA2 as a Critical Regulator in Cancer Development

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