HLA typing in Taiwanese patients with oral submucous fibrosis

Chen, Hsin‐Ming; Hsieh, Rhong-Phong; Yang, Hui‐Fang; Kuo, Ying-Shiung; Kuo, Mark Yen‐Ping; Chiang, Chun-Pin

doi:10.1111/j.0904-2512.2004.00195.x

Cited by 26 publications

(21 citation statements)

References 40 publications

(60 reference statements)

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“…Rapid development of OSMF in young adults or even children reported in clinical case reports further adds weight to this believe . HLA typing has shown certain HLA antigens with a significantly raised frequency in OSMF .…”

Section: Discussionmentioning

confidence: 86%

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Gadbail

Chaudhary

Gawande

et al. 2017

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 86%

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Gadbail

Chaudhary

Gawande

et al. 2017

J Oral Pathology Medicine

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“…[9] demonstrated that some Taiwanese betel‐quid chewers with particular HLA phenotypes and haplotypes are prone to develop OSF. In addition, some particular HLA haplotypes may play more important roles than individual HLA phenotypes for the genetic susceptibility to OSF [5]. Our previous studies revealed that the HLA‐DQA1 and HLA‐DQB1 allele frequencies in breast cancer patients showed no significant differences from those of control groups.…”

Section: Discussionmentioning

confidence: 96%

“…Chen et al. [5] found a significant increase in the frequency of HLA‐B76 and haplotype HLA‐B48/Cw7, B51/Cw7, and B62/Cw7 in OSF patients.…”

Section: Introductionmentioning

confidence: 99%

Association between HLA‐DQA1, HLA‐DQB1 and oral cancer

Tsai

Sheen

Chen

2011

The Kaohsiung J of Med Scie

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Cancer is one of the most common causes of morbidity and mortality. Genes whose products play a critical role in regulation of the immune response include the HLA antigen and cytokine families of genes. Oral cancer is common in men in developing countries, and its frequency is increased by using betel-quid, tobacco, and alcohol. The association between certain HLA Class I and Class II haplotypes and cancer has been documented in a variety of tumors. There was no previous data concerning the association of specific HLA Class II DQA1, DQB1 alleles, or haplotypes with oral cancer patients. In this study, we enrolled 134 Taiwanese patients with histologically confirmed oral cancer and 268 age- and gender-matched healthy Taiwanese adults as control group to investigate the association between HLA-DQA1, HLA-DQB1 allele frequencies and oral cancer patients by using polymerase chain reaction with sequence-specific primers. We found that both HLA-DQA1* and HLA-DQB1* allele frequencies in oral cancer patients revealed no significant difference from those of control groups. Haplotype frequencies of HLA*DQA1-0103-DQB1*0601 in oral cancer patients were significantly lower than those of the control group (odds ratio: 0.18, 95% confidence interval: 0.054-0.583, p(c)=0.02). Our data suggest that HLA DQA1*0103-DQB1*0601 haplotype may be protective with regard to the development of oral cancer.

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“… Nutritional factors: iron and vitamin B12 deficiency has been implicated particularly in conjunction with other factors 15 Genetic disposition: an increased frequency of HLA 10, DR3 and DR7 has been noted in patients with OSF 15,16 Hormonal factors: there would appear to be a predisposition in females 13,15 …”

Section: Discussionmentioning

confidence: 99%