HLA System in Japanese Patients with Diabetes Mellitus

Kawa, A.; Nakazawa, Michio; Sakaguchi, S; Nakamura, Shigetaka; Kono, Yukiharu; Hazeki, H; Kanehisa, Takuya

doi:10.2337/diab.26.6.591

Cited by 26 publications

(13 citation statements)

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“…HLA typing in this study revealed that the frequencies of HLA-BW54 and HLA-DR4, which are strongly associated with Japanese IDDM (12,26,27), are lower in these negative convertors of ICA than in persistently ICA-positive subjects (Table 3). On the other hand, the frequencies of HLA-BW54 and HLA-DR4 were high in persistently ICA-positive patients with NIDDM and IGT with slowly progressive clinical courses.…”

Section: Discussionmentioning

confidence: 66%

Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes

et al. 1987

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The time course of islet cell antibodies (ICA) and serum C-peptides responses (CPRs) to oral glucose tolerance tests (OGTTs) were studied prospectively up to 60 (mean 35) mo in 32 ICA-positive subjects [28 with non-insulin-dependent diabetes (NIDDM) and 4 subjects with impaired glucose tolerance (IGT); mean age 45 yr], 96 matched subjects [56 with NIDDM, 8 with IGT, and 32 normal first-degree relatives of patients with insulin-dependent diabetes (IDDM); mean age 45 yr] who were negative for ICA at the beginning of the study. In addition, the effects of human leukocyte antigens (HLA) on the time course of ICA and beta-cell function were evaluated. In 10 subjects (8 with NIDDM and 2 with IGT) who were ICA positive, ICA became undetectable, even by sensitive ICA assay, 15 +/- 2 mo (mean +/- SE) after initiation of this study. In these subjects, integrated serum CPR values (sigma CPR) and 2-h blood glucose values in response to OGTTs improved significantly (P less than .05-.01). In contrast, the remaining 22 subjects who were ICA positive were persistently positive for ICA. CPR and blood glucose responses deteriorated progressively in these 22 subjects, and 7 subjects in this group progressed to the insulin-dependent state. Serum CPR and blood glucose responses to OGTTs showed no remarkable changes in 64 patients (56 with NIDDM and 8 with IGT) and 32 normal first-degree relatives of patients with IDDM who remained negative for ICA throughout the study.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 66%

Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes

et al. 1987

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“…The black patients with Type 1 diabetes did not show any increase in the frequencies of CW3, B15, and B18 as has been found in European Caucasoids, nor of BW54 and B12 as observed in Japanese [1][2][3]. Studies in American blacks or Nigerians have not shown any significant association at the B locus [15][16][17].…”

Section: Discussionmentioning

confidence: 78%

“…HLA antigens associated with Type I diabetes in White Caucasoids include CW3, CW4, B8, B15, DW3, DW4, DR3 and DR4 [1]. In the Japanese, the disease has been associated with HLA-DYT and BW54 [2,3] while in South African Indians an association with B8 has been shown [4]. Other studies have shown a relationship with DR3 and DR4 in American blacks [5] and with either B8 or B14, which are cross-reacting antigens, in South African blacks [6].…”

mentioning

confidence: 99%

HLA-A, B, C and DR antigens in young South African blacks with Type 1 (insulin-dependent) diabetes mellitus

Omar

Hammond²,

Asmal

1984

Diabetologia

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Summary. The HLA status of South African black Type 1 (insulin-dependent) diabetic patients with age of onset under 35 years was compared with that of healthy black control subjects. HLA-A, B and C antigens were determined in 94 patients and 995 control subjects, while DR typing was carried out on 56 patients and 195 control subjects. There was a significant increase in the frequency of DR4 in patients as compared with control subjects (p<0.01; relative risk 3.4). DR3/DR4 heterozygosity was associated with a greater relative risk for developing Type 1 diabetes mellitus (3.7) than the presence of DR3 alone (relative risk 1.6). A significant negative association was observed between the presence of BW42 and Type 1 diabetes in this population sample (p < 0.04; relative risk 0.3). A similar trend was observed with regard to DR2, the corrected p value just attaining statistical significance (p< 0.05; relative risk 0.1).

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“…Our data also agree with some reports from Western countries [2,3], despite the fact that there are certain differences between Type 1 diabetes in Japanese and Caucasoid people. Typical juvenileonset Type 1 diabetes is less frequent in Japan than in Western countries [8] and is associated with different HLA antigens from those seen in Caucasoid patients [9,10]. Islet-cell antibodies are uncommonly demonstrated in Japanese patients with Type 1 diabetes [11].…”

Section: Discussionmentioning

confidence: 99%

Family histories of diabetes among Japanese patients with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes

Kuzuya

Matsuda

1982

Diabetologia

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Summary. Family histories of diabetes mellitus infirst-degree relatives were compared in Japanese patients with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes. The frequency of positive family histories for diabetes in first-degree relatives was 24% (13/55) in Type 1, 44% (281/631) in Type 2 (p < 0.01 versus Type 1) and 47% (16/34) when the type of diabetes could not be classified. The prevalence of diabetes in siblings of Type 2 patients was higher than in Type I diabetic patients (p < 0.01). Patients with Type 2 diabetes and definite obesity in the past had a lower frequency of a family history of diabetes (p < 0.01) and a lower prevalence of diabetes in their parents (p < 0.01) than did Type 2 patients without obesity. The highest rate of family history for diabetes was observed in non-obese Type 2 diabetic patients of early onset. Our data agree with the previously known higher frequency of familial diabetes in Type 2 compared with Type 1 diabetes, despite the fact that there are significant dissimilarities between Type 1 diabetes in Japanese and Caucasoid populations.

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HLA System in Japanese Patients with Diabetes Mellitus

Cited by 26 publications

References 0 publications

Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes

Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes

HLA-A, B, C and DR antigens in young South African blacks with Type 1 (insulin-dependent) diabetes mellitus

Family histories of diabetes among Japanese patients with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes

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