HLA-subtypes B*27 and ankylosing spondylitis features comments on Fellahi’s article “Are early onset of disease and uveitis affected by HLA- subtypes B*27 in ankylosing spondylitis?”

Slimani, Samy; Hamdi, Wafa; Nassar, K.

doi:10.1007/s10067-021-05838-w

Cited by 1 publication

(2 citation statements)

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“…In the general population, HLA-B27 prevalence extends from a lower range of 0.3-6.8% in Japanese, Sub-Saharan African, and most Arab populations to an upper range of 6-25% in Western European and North American populations [6][7][8][9][10]. The highest rates of HLA-B27 were reported in the populations of Papua New Guinea (13%-53%) and circumpolar populations including Chukchi and Inuit (25-50%) [11,12].…”

Section: Human Leucocyte Antigen-b27 Global Epidemiologymentioning

confidence: 99%

“…Also, several studies showed a higher male prevalence in HLA-B27–positive patients with axSpA, but the data are conflicting on this point [57,59–62]. Regarding joint topography, hip arthritis was more frequently reported in HLA-B27–positive patients with axSpA [7,24,63,64]. Also, in the particular case of patients with pSpA, HLA-B27 is associated with male sex, a shorted diagnostic delay, uveitis, tarsitis, axial involvement, and root joint disease, especially hip involvement related to SpA [62,65,66 ▪ ].…”

Section: Human Leucocyte Antigen-b27 and Spondyloarthritis Disease Ph...mentioning

confidence: 99%

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Human leucocyte antigen-B27 testing in clinical practice: a global perspective

Ziadé

2023

Current Opinion in Rheumatology

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Purpose of reviewThe association between human leucocyte antigen (HLA)-B27 and spondyloarthritis (SpA) was described half a century ago. New insights about pathophysiologic pathways and their role in bone formation were reported in recent years and will be discussed in this review. Recent findingsThere is a considerable variation in the association between HLA-B27 and SpA across the globe, with the strongest association reported in populations of Northern European and Asian descent and the lowest in the Middle East and Africa. Other genes are also involved in disease susceptibility, highlighting the importance of newly proposed weighted genetic scores to support the diagnosis. On the global level, the interaction between genetic background and gut dysbiosis seems critical for disease predisposition. As for the individual patient, the presence of HLA-B27 can have a significant influence on SpA diagnosis and disease phenotype. More importantly, new studies suggested a role for HLA-B27 in radiographic damage in the sacroiliac joints and the progression of bone formation in the spine. SummaryFindings in recent years have enhanced our understanding of the role of HLA-B27 in the pathophysiology and in disease-related bone formation in SpA, which may pave the way for new therapeutic targets.

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