HLA repertoire of 115 UAE nationals infected with SARS-CoV-2

Alnaqbi, Halima; Tay, Guan K.; Jelinek, Herbert F.; Francis, Amirtharaj; Alefishat, Eman; Chehadeh, Sarah El Haj; Saeed, Amna Tahir; Hussein, Mawada; Salameh, Laila; Mahboub, Bassam; Uddin, Maimunah; Kaabi, Nawal Al; Alsafar, Habiba; Partnership, Uae Covid Collaborative

doi:10.1016/j.humimm.2021.08.012

Cited by 12 publications

(16 citation statements)

References 46 publications

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“…were significantly discordant, 48 while the opposing effect on disease severity was shown in studies conducted in Russia and United Arab Emirates (UAE). 45 , 51 As for HLA‐A*23, the relation of this allelic group with COVID‐19 severity was reported in Greek population, 28 while Littera et al . found HLA‐A*23:01 allele exclusively in hospitalised patients from their Sardinian cohort.…”

Section: Discussionmentioning

confidence: 90%

“…In the first two years of extensive research in the area of molecular genetics of COVID‐19, a significant number of association studies related to the disease severity, clinical course and the outcome of SARS‐CoV‐2 infection focused on host polymorphisms in HLA loci. 13 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 These studies were driven by previous results suggesting the involvement of HLA system in the regulation of the immune response to other viruses, as well as by the fine regulation of peptide‐binding properties by the extreme polymorphic feature of HLA loci. 61 , 62 …”

Section: Discussionmentioning

confidence: 99%

“…To date, the only allelic variants of this locus identified as predisposing factors for worse clinical manifestation of SARS‐CoV‐2 infection in more than a single study are HLA‐B*51 and HLA‐B*35. HLA‐B*51:01 was previously reported in the GWAS from China as a predisposing allele for severe COVID‐19, 21 while the opposite effect on COVID‐19‐related hospitalisation was determined in a study conducted in UAE, 51 which analysed the association under dominant model. Naemi et al.…”

Section: Discussionmentioning

confidence: 99%

“…Based on this hypothesis, a relatively large number of studies investigated the role of HLA class I and class II alleles as predictors of COVID‐19 clinical course and the disease outcome. 13 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 However, their results varied significantly, possibly due to the differences in the study designs, severity‐based classification criteria, ethnicity of participants, or other factors with potential confounding effects. The observed heterogeneity between these studies makes it difficult to comprehensively assess the impact of allelic variants on disease severity.…”

Section: Introductionmentioning

confidence: 99%

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The association of human leucocyte antigen (HLA) alleles with COVID‐19 severity: A systematic review and meta‐analysis

Dobrijević

Gligorijević

Šunderić

et al. 2022

Reviews in Medical Virology

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Due to their pivotal role in orchestrating the immune response, HLA loci were recognized as candidates for genetic association studies related to the severity of COVID‐19. Since the findings on the effects of HLA alleles on the outcome of SARS‐CoV‐2 infection remain inconclusive, we aimed to elucidate the potential involvement of genetic variability within HLA loci in the molecular genetics of COVID‐19 by classifying the articles according to different disease severity/outcomes and by conducting a systematic review with meta‐analysis. Potentially eligible studies were identified by searching PubMed, Scopus and Web of Science literature databases. A total of 28 studies with 13,073 participants were included in qualitative synthesis, while the results of 19 studies with 10,551 SARS‐CoV‐2‐positive participants were pooled in the meta‐analysis. According to the results of quantitative data synthesis, association with COVID‐19 severity or with the lethal outcome was determined for the following alleles and allele families: HLA‐A*01, HLA‐A*03, HLA‐A*11, HLA‐A*23, HLA‐A*31, HLA‐A*68, HLA‐A*68:02, HLA‐B*07:02, HLA‐B*14, HLA‐B*15, HLA‐B*40:02, HLA‐B*51:01, HLA‐B*53, HLA‐B*54, HLA‐B*54:01, HLA‐C*04, HLA‐C*04:01, HLA‐C*06, HLA‐C*07:02, HLA‐DRB1*11, HLA‐DRB1*15, HLA‐DQB1*03 and HLA‐DQB1*06 (assuming either allelic or dominant genetic model). We conclude that alleles of HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 loci may represent potential biomarkers of COVID‐19 severity and/or mortality, which needs to be confirmed in a larger set of studies.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The association of human leucocyte antigen (HLA) alleles with COVID‐19 severity: A systematic review and meta‐analysis

Dobrijević

Gligorijević

Šunderić

et al. 2022

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…In a population from the United Arab Emirates, the alleles HLA-B*51:01 and HLA-A*26:01 were found to be negatively correlated with COVID - 19 severity, while HLA-A*03:01, HLA-DRB1*15:01 carriers, as well as B*44 supertype, were positively linked with pathology [9] .…”

Section: Introductionmentioning

confidence: 91%